dbPTM

FMT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FMT_HUMAN
UniProt AC	Q96DP5
Protein Name	Methionyl-tRNA formyltransferase, mitochondrial
Gene Name	MTFMT
Organism	Homo sapiens (Human).
Sequence Length	389
Subcellular Localization	Mitochondrion.
Protein Description	Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and an elongator species via an unknown mechanism (By similarity)..
Protein Sequence	MRVLVRRCWGPPLAHGARRGRPSPQWRALARLGWEDCRDSRVREKPPWRVLFFGTDQFAREALRALHAARENKEEELIDKLEVVTMPSPSPKGLPVKQYAVQSQLPVYEWPDVGSGEYDVGVVASFGRLLNEALILKFPYGILNVHPSCLPRWRGPAPVIHTVLHGDTVTGVTIMQIRPKRFDVGPILKQETVPVPPKSTAKELEAVLSRLGANMLISVLKNLPESLSNGRQQPMEGATYAPKISAGTSCIKWEEQTSEQIFRLYRAIGNIIPLQTLWMANTIKLLDLVEVNSSVLADPKLTGQALIPGSVIYHKQSQILLVYCKDGWIGVRSVMLKKSLTATDFYNGYLHPWYQKNSQAQPSQCRFQTLRLPTKKKQKKTVAMQQCIE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	GARRGRPSPQWRALA CCCCCCCCHHHHHHH	28.50	24719451
85	Phosphorylation	IDKLEVVTMPSPSPK HHHEEEEECCCCCCC	28.65	26270265
88	Phosphorylation	LEVVTMPSPSPKGLP EEEEECCCCCCCCCC	27.47	26270265
90	Phosphorylation	VVTMPSPSPKGLPVK EEECCCCCCCCCCHH	43.51	29978859
92	Acetylation	TMPSPSPKGLPVKQY ECCCCCCCCCCHHHE	76.92	7462169
257	Phosphorylation	CIKWEEQTSEQIFRL CCCCCHHHHHHHHHH	37.19	22210691
258	Phosphorylation	IKWEEQTSEQIFRLY CCCCHHHHHHHHHHH	27.48	22210691
265	Phosphorylation	SEQIFRLYRAIGNII HHHHHHHHHHHCCCC	8.17	22210691
374	Phosphorylation	FQTLRLPTKKKQKKT CCEECCCCCCHHHHC	61.15	22964224
381	Phosphorylation	TKKKQKKTVAMQQCI CCCHHHHCHHHHHHC	22.12	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FMT_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FMT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FMT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FMT_HUMAN

Related Literatures of Post-Translational Modification