SHRM4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SHRM4_HUMAN
• UniProt AC: Q9ULL8
• Protein Name: Protein Shroom4
• Gene Name: SHROOM4
• Organism: Homo sapiens (Human).
• Sequence Length: 1493
• Subcellular Localization: Cytoplasm, cytoskeleton . Shows partial colocalization with the cytoplasmic pool of F-actin.
• Protein Description: Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity)..
• Protein Sequence: MENRPGSFQYVPVQLQGGAPWGFTLKGGLEHCEPLTVSKIEDGGKAALSQKMRTGDELVNINGTPLYGSRQEALILIKGSFRILKLIVRRRNAPVSRPHSWHVAKLLEGCPEAATTMHFPSEAFSLSWHSGCNTSDVCVQWCPLSRHCSTEKSSSIGSMESLEQPGQATYESHLLPIDQNMYPNQRDSAYSSFSASSNASDCALSLRPEEPASTDCIMQGPGPTKAPSGRPNVAETSGGSRRTNGGHLTPSSQMSSRPQEGYQSGPAKAVRGPPQPPVRRDSLQASRAQLLNGEQRRASEPVVPLPQKEKLSLEPVLPARNPNRFCCLSGHDQVTSEGHQNCEFSQPPESSQQGSEHLLMQASTKAVGSPKACDRASSVDSNPLNEASAELAKASFGRPPHLIGPTGHRHSAPEQLLASHLQHVHLDTRGSKGMELPPVQDGHQWTLSPLHSSHKGKKSPCPPTGGTHDQSSKERKTRQVDDRSLVLGHQSQSSPPHGEADGHPSEKGFLDPNRTSRAASELANQQPSASGSLVQQATDCSSTTKAASGTEAGEEGDSEPKECSRMGGRRSGGTRGRSIQNRRKSERFATNLRNEIQRRKAQLQKSKGPLSQLCDTKEPVEETQEPPESPPLTASNTSLLSSCKKPPSPRDKLFNKSMMLRARSSECLSQAPESHESRTGLEGRISPGQRPGQSSLGLNTWWKAPDPSSSDPEKAHAHCGVRGGHWRWSPEHNSQPLVAAAMEGPSNPGDNKELKASTAQAGEDAILLPFADRRKFFEESSKSLSTSHLPGLTTHSNKTFTQRPKPIDQNFQPMSSSCRELRRHPMDQSYHSADQPYHATDQSYHSMSPLQSETPTYSECFASKGLENSMCCKPLHCGDFDYHRTCSYSCSVQGALVHDPCIYCSGEICPALLKRNMMPNCYNCRCHHHQCIRCSVCYHNPQHSALEDSSLAPGNTWKPRKLTVQEFPGDKWNPITGNRKTSQSGREMAHSKTSFSWATPFHPCLENPALDLSSYRAISSLDLLGDFKHALKKSEETSVYEEGSSLASMPHPLRSRAFSESHISLAPQSTRAWGQHRRELFSKGDETQSDLLGARKKAFPPPRPPPPNWEKYRLFRAAQQQKQQQQQQKQQEEEEEEEEEEEEEEEEEEEEAEEEEEELPPQYFSSETSGSCALNPEEVLEQPQPLSFGHLEGSRQGSQSVPAEQESFALHSSDFLPPIRGHLGSQPEQAQPPCYYGIGGLWRTSGQEATESAKQEFQHFSPPSGAPGIPTSYSAYYNISVAKAELLNKLKDQPEMAEIGLGEEEVDHELAQKKIQLIESISRKLSVLREAQRGLLEDINANSALGEEVEANLKAVCKSNEFEKYHLFVGDLDKVVNLLLSLSGRLARVENALNSIDSEANQEKLVLIEKKQQLTGQLADAKELKEHVDRREKLVFGMVSRYLPQDQLQDYQHFVKMKSALIIEQRELEEKIKLGEEQLKCLRESLLLGPSNF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
80	Phosphorylation	ALILIKGSFRILKLI EEEEEECHHHHHHHH	13.32	-
100	Phosphorylation	APVSRPHSWHVAKLL CCCCCCCHHHHHHHH	22.89	23403867
153	Phosphorylation	RHCSTEKSSSIGSME CCCCCCCCCCCCCHH	24.08	28270605
154	Phosphorylation	HCSTEKSSSIGSMES CCCCCCCCCCCCHHH	36.72	28270605
155	Phosphorylation	CSTEKSSSIGSMESL CCCCCCCCCCCHHHC	37.75	28270605
158	Phosphorylation	EKSSSIGSMESLEQP CCCCCCCCHHHCCCC	20.08	28270605
161	Phosphorylation	SSIGSMESLEQPGQA CCCCCHHHCCCCCCC	28.68	28270605
169	Phosphorylation	LEQPGQATYESHLLP CCCCCCCCCHHCEEE	21.67	24043423
170	Phosphorylation	EQPGQATYESHLLPI CCCCCCCCHHCEEEC	20.60	24043423
172	Phosphorylation	PGQATYESHLLPIDQ CCCCCCHHCEEECCC	14.71	24043423
182	Phosphorylation	LPIDQNMYPNQRDSA EECCCCCCCCCCCHH	13.43	24043423
205	Phosphorylation	NASDCALSLRPEEPA CHHCCCCCCCCCCCC	12.10	24719451
282	Phosphorylation	QPPVRRDSLQASRAQ CCCCCHHHHHHHHHH	22.14	23403867
286	Phosphorylation	RRDSLQASRAQLLNG CHHHHHHHHHHHHCC	18.39	24702127
299	Phosphorylation	NGEQRRASEPVVPLP CCCCCCCCCCCCCCC	40.39	29255136
312	Phosphorylation	LPQKEKLSLEPVLPA CCCCCCCCCCCCCCC	41.58	23312004
377	Phosphorylation	PKACDRASSVDSNPL HHHCCCCCCCCCCCC	31.61	23403867
378	Phosphorylation	KACDRASSVDSNPLN HHCCCCCCCCCCCCH	29.03	26657352
381	Phosphorylation	DRASSVDSNPLNEAS CCCCCCCCCCCHHHH	37.89	23403867
411	Phosphorylation	GPTGHRHSAPEQLLA CCCCCCCCCHHHHHH	45.54	29255136
459	Phosphorylation	SSHKGKKSPCPPTGG CCCCCCCCCCCCCCC	34.91	25850435
464	Phosphorylation	KKSPCPPTGGTHDQS CCCCCCCCCCCCCCC	33.13	25850435
467	Phosphorylation	PCPPTGGTHDQSSKE CCCCCCCCCCCCHHC	24.51	25850435
471	Phosphorylation	TGGTHDQSSKERKTR CCCCCCCCHHCCCCC	49.81	25850435
472	Phosphorylation	GGTHDQSSKERKTRQ CCCCCCCHHCCCCCC	32.66	25850435
484	Phosphorylation	TRQVDDRSLVLGHQS CCCCCCCHHHCCCCC	29.80	28060719
491	Phosphorylation	SLVLGHQSQSSPPHG HHHCCCCCCCCCCCC	26.76	23403867
493	Phosphorylation	VLGHQSQSSPPHGEA HCCCCCCCCCCCCCC	50.49	23403867
494	Phosphorylation	LGHQSQSSPPHGEAD CCCCCCCCCCCCCCC	34.51	23403867
505	Phosphorylation	GEADGHPSEKGFLDP CCCCCCCCCCCCCCC	46.39	23403867
548	Phosphorylation	SSTTKAASGTEAGEE CCCCCCCCCCCCCCC	51.62	-
550	Phosphorylation	TTKAASGTEAGEEGD CCCCCCCCCCCCCCC	21.84	-
571	Phosphorylation	SRMGGRRSGGTRGRS HCCCCCCCCCCCCHH	39.97	-
574	Phosphorylation	GGRRSGGTRGRSIQN CCCCCCCCCCHHHHH	33.21	-
590	Phosphorylation	RKSERFATNLRNEIQ HHHHHHHHHHHHHHH	31.88	23403867
606	Phosphorylation	RKAQLQKSKGPLSQL HHHHHHHCCCCHHHH	29.86	25002506
611	Phosphorylation	QKSKGPLSQLCDTKE HHCCCCHHHHCCCCC	25.00	25002506
616	Phosphorylation	PLSQLCDTKEPVEET CHHHHCCCCCCCCCC	35.99	25002506
623	Phosphorylation	TKEPVEETQEPPESP CCCCCCCCCCCCCCC	25.40	28270605
629	Phosphorylation	ETQEPPESPPLTASN CCCCCCCCCCCCCCC	37.28	28270605
633	Phosphorylation	PPESPPLTASNTSLL CCCCCCCCCCCCHHH	33.54	28270605
635	Phosphorylation	ESPPLTASNTSLLSS CCCCCCCCCCHHHHH	35.09	28270605
637	Phosphorylation	PPLTASNTSLLSSCK CCCCCCCCHHHHHCC	20.46	28270605
638	Phosphorylation	PLTASNTSLLSSCKK CCCCCCCHHHHHCCC	31.40	28270605
664	Phosphorylation	SMMLRARSSECLSQA HHHHHHHCHHHHHHC	29.51	29255136
665	Phosphorylation	MMLRARSSECLSQAP HHHHHHCHHHHHHCC	27.12	29255136
669	Phosphorylation	ARSSECLSQAPESHE HHCHHHHHHCCCCCH	35.63	23403867
674	Phosphorylation	CLSQAPESHESRTGL HHHHCCCCCHHCCCC	31.34	23403867
677	Phosphorylation	QAPESHESRTGLEGR HCCCCCHHCCCCCCC	29.71	23403867
686	Phosphorylation	TGLEGRISPGQRPGQ CCCCCCCCCCCCCCC	22.93	23403867
694	Phosphorylation	PGQRPGQSSLGLNTW CCCCCCCCCCCCCCC	33.18	23403867
695	Phosphorylation	GQRPGQSSLGLNTWW CCCCCCCCCCCCCCE	20.69	23403867
700	Phosphorylation	QSSLGLNTWWKAPDP CCCCCCCCCEECCCC	37.43	27251275
729	Phosphorylation	RGGHWRWSPEHNSQP CCCCCCCCCCCCCCC	16.31	23403867
734	Phosphorylation	RWSPEHNSQPLVAAA CCCCCCCCCCCEEHH	34.77	23403867
783	Phosphorylation	FFEESSKSLSTSHLP HHHHHHCCCCCCCCC	29.51	23403867
785	Phosphorylation	EESSKSLSTSHLPGL HHHHCCCCCCCCCCC	34.65	23403867
786	Phosphorylation	ESSKSLSTSHLPGLT HHHCCCCCCCCCCCC	26.01	23403867
787	Phosphorylation	SSKSLSTSHLPGLTT HHCCCCCCCCCCCCC	21.46	23403867
794	Phosphorylation	SHLPGLTTHSNKTFT CCCCCCCCCCCCCCC	28.48	26503514
796	Phosphorylation	LPGLTTHSNKTFTQR CCCCCCCCCCCCCCC	37.62	26503514
885	Phosphorylation	GDFDYHRTCSYSCSV CCCCCCCCCCCCCEE	7.78	27251275
887	Phosphorylation	FDYHRTCSYSCSVQG CCCCCCCCCCCEECC	21.33	27251275
889	Phosphorylation	YHRTCSYSCSVQGAL CCCCCCCCCEECCCC	5.43	27251275
891	Phosphorylation	RTCSYSCSVQGALVH CCCCCCCEECCCCCC	16.13	27251275
1019	Phosphorylation	LSSYRAISSLDLLGD HHHHHHHHHHHHHHH	24.70	29255136
1020	Phosphorylation	SSYRAISSLDLLGDF HHHHHHHHHHHHHHH	21.57	29255136
1034	Phosphorylation	FKHALKKSEETSVYE HHHHHHHCCCCCCCC	38.79	28450419
1037	Phosphorylation	ALKKSEETSVYEEGS HHHHCCCCCCCCCCC	21.31	28450419
1038	Phosphorylation	LKKSEETSVYEEGSS HHHCCCCCCCCCCCC	26.44	28450419
1040	Phosphorylation	KSEETSVYEEGSSLA HCCCCCCCCCCCCHH	14.18	28450419
1044	Phosphorylation	TSVYEEGSSLASMPH CCCCCCCCCHHCCCC	26.01	28450419
1045	Phosphorylation	SVYEEGSSLASMPHP CCCCCCCCHHCCCCC	38.52	28450419
1048	Phosphorylation	EEGSSLASMPHPLRS CCCCCHHCCCCCHHH	37.83	-
1059	Phosphorylation	PLRSRAFSESHISLA CHHHCCCCHHHCCCC	36.89	29255136
1061	Phosphorylation	RSRAFSESHISLAPQ HHCCCCHHHCCCCCC	25.56	23403867
1064	Phosphorylation	AFSESHISLAPQSTR CCCHHHCCCCCCCCC	17.04	23403867
1069	Phosphorylation	HISLAPQSTRAWGQH HCCCCCCCCCHHHHH	20.85	23403867
1070	Phosphorylation	ISLAPQSTRAWGQHR CCCCCCCCCHHHHHH	21.11	23403867
1082	Phosphorylation	QHRRELFSKGDETQS HHHHHHHHCCCCHHH	48.64	22817900
1087	Phosphorylation	LFSKGDETQSDLLGA HHHCCCCHHHHHHCC	37.81	22817900
1089	Phosphorylation	SKGDETQSDLLGARK HCCCCHHHHHHCCHH	37.33	22817900
1326	Phosphorylation	ESISRKLSVLREAQR HHHHHHHHHHHHHHH	23.34	24719451
1343	Phosphorylation	LEDINANSALGEEVE HHHCCCCCCCCHHHH	23.59	-
1381	Phosphorylation	KVVNLLLSLSGRLAR HHHHHHHHHHHHHHH	22.06	-
1383	Phosphorylation	VNLLLSLSGRLARVE HHHHHHHHHHHHHHH	20.63	-
1459	Phosphorylation	QHFVKMKSALIIEQR HHHHHHHHHHHHCHH	25.47	30622161

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SHRM4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SHRM4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SHRM4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SHRM4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 300434: Mental retardation, X-linked, syndromic, Stocco dos Santos type (SDSX)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.