LETM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LETM2_HUMAN
• UniProt AC: Q2VYF4
• Protein Name: LETM1 domain-containing protein LETM2, mitochondrial
• Gene Name: LETM2
• Organism: Homo sapiens (Human).
• Sequence Length: 491
• Subcellular Localization: Mitochondrion inner membrane; Single-pass membrane protein.
• Protein Sequence: MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSCAFLHLPDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGKPQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQKIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRRLLRTCVDFFRLVPFMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKKEEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEAPKTDILVELPTFTESKENMVDLAPQLKGTKDEDFIQPPPVTSSPITPSTPISLPKGPITSSEEPTLQAKSQMTAQNSKASSKGA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
71	Phosphorylation	NTVLHPGTRLIQKLH CCEECCCHHHHHHHC	27.10	-
125	Acetylation	GKQSYRQKIMDELKY CCHHHHHHHHHHHHH	30.88	11790801
131	Acetylation	QKIMDELKYYYNGFY HHHHHHHHHHHCCEE	29.20	11790809
206	Phosphorylation	KLFPEMLPSTFESES HHCHHHCCCCCCCCC	29.97	24719451
207	Phosphorylation	LFPEMLPSTFESESK HCHHHCCCCCCCCCH	41.59	-
226	Ubiquitination	QKKKMAVKLELAKFL HHHHHHHHHHHHHHH	27.06	-
236	Phosphorylation	LAKFLQETMTEMARR HHHHHHHHHHHHHHH	19.21	24043423
238	Phosphorylation	KFLQETMTEMARRNR HHHHHHHHHHHHHHH	29.99	24043423
253	Phosphorylation	AKMGDASTQLSSYVK HHHCCHHHHHHHHHH	34.94	24719451
257	Phosphorylation	DASTQLSSYVKQVQT CHHHHHHHHHHHHHC	42.40	28387310
258	Phosphorylation	ASTQLSSYVKQVQTG HHHHHHHHHHHHHCC	14.32	-
270	Phosphorylation	QTGHKPSTKEIVRFS HCCCCCCHHHHHHHH	41.02	-
289	Phosphorylation	DQLALEHLDRPQLVA CHHHHHCCCHHHHHH	4.33	24719451
292	Phosphorylation	ALEHLDRPQLVALCK HHHCCCHHHHHHHHH	31.37	24719451
294	Phosphorylation	EHLDRPQLVALCKLL HCCCHHHHHHHHHHH	2.42	24719451
336	Phosphorylation	IIAKEGVTALSVSEL HHHCCCCCEEEHHHH	32.51	24719451
339	Phosphorylation	KEGVTALSVSELQAA CCCCCEEEHHHHHHH	22.57	24719451
341	Phosphorylation	GVTALSVSELQAACR CCCEEEHHHHHHHHH	29.25	24719451
354	Phosphorylation	CRARGMRSLGLTEEQ HHHCCCHHCCCCHHH	20.21	28176443
358	Phosphorylation	GMRSLGLTEEQLRQQ CCHHCCCCHHHHHHH	35.36	28176443
436	Phosphorylation	LAPQLKGTKDEDFIQ HCHHCCCCCCCCCCC	33.46	23312004
448	Phosphorylation	FIQPPPVTSSPITPS CCCCCCCCCCCCCCC	29.30	23312004
449	Phosphorylation	IQPPPVTSSPITPST CCCCCCCCCCCCCCC	34.06	23312004
450	Phosphorylation	QPPPVTSSPITPSTP CCCCCCCCCCCCCCC	15.79	27050516
453	Phosphorylation	PVTSSPITPSTPISL CCCCCCCCCCCCCCC	17.99	23312004
455	Phosphorylation	TSSPITPSTPISLPK CCCCCCCCCCCCCCC	37.86	21712546
456	Phosphorylation	SSPITPSTPISLPKG CCCCCCCCCCCCCCC	26.33	27050516
459	Phosphorylation	ITPSTPISLPKGPIT CCCCCCCCCCCCCCC	39.56	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LETM2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LETM2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LETM2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.