TNR19_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNR19_HUMAN
• UniProt AC: Q9NS68
• Protein Name: Tumor necrosis factor receptor superfamily member 19
• Gene Name: TNFRSF19
• Organism: Homo sapiens (Human).
• Sequence Length: 423
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Description: Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death..
• Protein Sequence: MALKVLLEQEKTFFTLLVLLGYLSCKVTCESGDCRQQEFRDRSGNCVPCNQCGPGMELSKECGFGYGEDAQCVTCRLHRFKEDWGFQKCKPCLDCAVVNRFQKANCSATSDAICGDCLPGFYRKTKLVGFQDMECVPCGDPPPPYEPHCASKVNLVKIASTASSPRDTALAAVICSALATVLLALLILCVIYCKRQFMEKKPSWSLRSQDIQYNGSELSCFDRPQLHEYAHRACCQCRRDSVQTCGPVRLLPSMCCEEACSPNPATLGCGVHSAASLQARNAGPAGEMVPTFFGSLTQSICGEFSDAWPLMQNPMGGDNISFCDSYPELTGEDIHSLNPELESSTSLDSNSSQDLVGGAVPVQSHSENFTAATDLSRYNNTLVESASTQDALTMRSQLDQESGAVIHPATQTSLQVRQRLGSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
105	N-linked_Glycosylation	VNRFQKANCSATSDA HHHHHHCCCCCCCCC	27.58	UniProtKB CARBOHYD
110	Phosphorylation	KANCSATSDAICGDC HCCCCCCCCCCCCCC	25.43	-
122	Phosphorylation	GDCLPGFYRKTKLVG CCCCCCCHHCCCEEC	19.67	-
125	Phosphorylation	LPGFYRKTKLVGFQD CCCCHHCCCEECCCC	22.17	-
205	Phosphorylation	MEKKPSWSLRSQDIQ HHHCCCCCCCCCCCE	20.45	24719451
216	Phosphorylation	QDIQYNGSELSCFDR CCCEECCCEECCCCC	31.55	-
241	Phosphorylation	CCQCRRDSVQTCGPV HHHCCCCCCCCCCCC	17.82	29255136
244	Phosphorylation	CRRDSVQTCGPVRLL CCCCCCCCCCCCEEC	19.78	25850435
253	Phosphorylation	GPVRLLPSMCCEEAC CCCEECCHHHCHHHC	25.15	25850435
261	Phosphorylation	MCCEEACSPNPATLG HHCHHHCCCCCCCCC	34.46	25850435
266	Phosphorylation	ACSPNPATLGCGVHS HCCCCCCCCCCCHHH	25.58	25850435
378	Phosphorylation	AATDLSRYNNTLVES EECHHHHHCCCCCCC	14.91	-
393	Phosphorylation	ASTQDALTMRSQLDQ CHHHHHHHHHHHHHH	16.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TNR19_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNR19_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNR19_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRAF1_MOUSE	Traf1	physical	10809768
TRAF2_MOUSE	Traf2	physical	10809768
TRAF3_MOUSE	Traf3	physical	10809768
TRAF5_MOUSE	Traf5	physical	10809768
CYTT_HUMAN	CST2	physical	28514442
TYK2_HUMAN	TYK2	physical	28514442
KLK10_HUMAN	KLK10	physical	28514442
ZN101_HUMAN	ZNF101	physical	28514442
CALL5_HUMAN	CALML5	physical	28514442
CRNN_HUMAN	CRNN	physical	28514442
FILA_HUMAN	FLG	physical	28514442
CYTN_HUMAN	CST1	physical	28514442
PHLB3_HUMAN	PHLDB3	physical	28514442
ZN865_HUMAN	ZNF865	physical	28514442
ZN100_HUMAN	ZNF100	physical	28514442
PKHG4_HUMAN	PLEKHG4	physical	28514442
CYTS_HUMAN	CST4	physical	28514442
SMR3B_HUMAN	SMR3B	physical	28514442
PLD1_HUMAN	PLD1	physical	28514442
ZDH17_HUMAN	ZDHHC17	physical	28514442
JPH1_HUMAN	JPH1	physical	28514442
ZN696_HUMAN	ZNF696	physical	28514442
ZN444_HUMAN	ZNF444	physical	28514442
TPC1_HUMAN	TPCN1	physical	28514442
CALL3_HUMAN	CALML3	physical	28514442
PI42C_HUMAN	PIP4K2C	physical	28514442
NEDD4_HUMAN	NEDD4	physical	28514442
PEPL_HUMAN	PPL	physical	28514442
MBRL_HUMAN	TMEM259	physical	28514442
LGR4_HUMAN	LGR4	physical	28514442
HASP_HUMAN	GSG2	physical	28514442
WWP1_HUMAN	WWP1	physical	28514442
ZKSC1_HUMAN	ZKSCAN1	physical	28514442
PLD2_HUMAN	PLD2	physical	28514442
MA7D1_HUMAN	MAP7D1	physical	28514442
P52K_HUMAN	PRKRIR	physical	28514442
MAP2_HUMAN	METAP2	physical	28514442
PKP2_HUMAN	PKP2	physical	28514442
NOP56_HUMAN	NOP56	physical	28514442
NED4L_HUMAN	NEDD4L	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.