BARX2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BARX2_HUMAN
• UniProt AC: Q9UMQ3
• Protein Name: Homeobox protein BarH-like 2
• Gene Name: BARX2
• Organism: Homo sapiens (Human).
• Sequence Length: 279
• Subcellular Localization: Nucleus.
• Protein Description: Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity)..
• Protein Sequence: MHCHAELRLSSPGQLKAARRRYKTFMIDEILSKETCDYFEKLSLYSVCPSLVVRPKPLHSCTGSPSLRAYPLLSVITRQPTVISHLVPATPGIAQALSCHQVTEAVSAEAPGGEALASSESETEQPTPRQKKPRRSRTIFTELQLMGLEKKFQKQKYLSTPDRLDLAQSLGLTQLQVKTWYQNRRMKWKKMVLKGGQEAPTKPKGRPKKNSIPTSEEIEAEEKMNSQAQGQEQLEPSQGQEELCEAQEPKARDVPLEMAEPPDPPQELPIPSSEPPPLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	CHAELRLSSPGQLKA CCEEEECCCHHHHHH	28.22	28348404
11	Phosphorylation	HAELRLSSPGQLKAA CEEEECCCHHHHHHH	37.33	24719451
23	Ubiquitination	KAARRRYKTFMIDEI HHHHHHHHHHHHHHH	33.21	21890473
23	Ubiquitination	KAARRRYKTFMIDEI HHHHHHHHHHHHHHH	33.21	21890473
136	Phosphorylation	RQKKPRRSRTIFTEL CCCCCCHHHHHHHHH	34.75	17081983
159	Phosphorylation	FQKQKYLSTPDRLDL HHHCCCCCCCCHHHH	34.50	28348404
160	Phosphorylation	QKQKYLSTPDRLDLA HHCCCCCCCCHHHHH	26.98	28348404
187	Acetylation	WYQNRRMKWKKMVLK HHHHHHHHHHEEHHC	54.79	7668879
189	Acetylation	QNRRMKWKKMVLKGG HHHHHHHHEEHHCCC	26.02	7668887
194	Trimethylation	KWKKMVLKGGQEAPT HHHEEHHCCCCCCCC	49.97	-
194	Acetylation	KWKKMVLKGGQEAPT HHHEEHHCCCCCCCC	49.97	7668895
194	Methylation	KWKKMVLKGGQEAPT HHHEEHHCCCCCCCC	49.97	-
211	Phosphorylation	KGRPKKNSIPTSEEI CCCCCCCCCCCHHHH	38.53	25849741
212	Phosphorylation	GRPKKNSIPTSEEIE CCCCCCCCCCHHHHH	6.36	17525332
214	Phosphorylation	PKKNSIPTSEEIEAE CCCCCCCCHHHHHHH	47.29	23312004
215	Phosphorylation	KKNSIPTSEEIEAEE CCCCCCCHHHHHHHH	28.07	23312004
237	Phosphorylation	GQEQLEPSQGQEELC HHHHCCCCHHHHHHH	37.25	17525332

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BARX2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BARX2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BARX2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of BARX2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-237, AND MASSSPECTROMETRY.
PubMed: 17525332