MYB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYB_MOUSE
• UniProt AC: P06876
• Protein Name: Transcriptional activator Myb
• Gene Name: Myb
• Organism: Mus musculus (Mouse).
• Sequence Length: 636
• Subcellular Localization: Nucleus.
• Protein Description: Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells..
• Protein Sequence: MARRPRHSIYSSDEDDEDIEMCDHDYDGLLPKSGKRHLGKTRWTREEDEKLKKLVEQNGTDDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNAIKNHWNSTMRRKVEQEGYLQEPSKASQTPVATSFQKNNHLMGFGHASPPSQLSPSGQSSVNSEYPYYHIAEAQNISSHVPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELELLLMSTENELKGQQALPTQNHTCSYPGWHSTSIVDQTRPHGDSAPVSCLGEHHATPSLPADPGSLPEESASPARCMIVHQGTILDNVKNLLEFAETLQFIDSFLNTSSNHESSGLDAPTLPSTPLIGHKLTPCRDQTVKTQKENSIFRTPAIKRSILESSPRTPTPFKHALAAQEIKYGPLKMLPQTPSHAVEDLQDVIKQESDESGIVAEFQESGPPLLKKIKQEVESPTEKSGNFFCSNHWAENSLSTQLFSQASPVADAPNILTSSVLMTPVSEDEDNVLKAFTVPKNRPLVGPLQPCSGAWEPASCGKTEDQMTASGPARKYVNAFSARTLVM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	RPRHSIYSSDEDDED CCCCCCCCCCCCHHH	29.64	10851088
12	Phosphorylation	PRHSIYSSDEDDEDI CCCCCCCCCCCHHHH	28.22	10851088
198	Phosphorylation	RKVEQEGYLQEPSKA HHHHHCCCCCCCCCC	12.40	27180971
203	Phosphorylation	EGYLQEPSKASQTPV CCCCCCCCCCCCCCC	39.85	27180971
208	Phosphorylation	EPSKASQTPVATSFQ CCCCCCCCCCEECCC	19.75	-
354	Phosphorylation	CLGEHHATPSLPADP HHCCCCCCCCCCCCC	14.73	18006338
438	Acetylation	PCRDQTVKTQKENSI CCCCCCCCCCHHCCC	48.93	11073948
441	Acetylation	DQTVKTQKENSIFRT CCCCCCCHHCCCCCC	65.18	11073948
444	Phosphorylation	VKTQKENSIFRTPAI CCCCHHCCCCCCHHH	24.97	-
454	O-linked_Glycosylation	RTPAIKRSILESSPR CCHHHHHHHHHCCCC	26.90	51588161
462	Phosphorylation	ILESSPRTPTPFKHA HHHCCCCCCCCCHHH	34.59	27600695
464	Phosphorylation	ESSPRTPTPFKHALA HCCCCCCCCCHHHHH	40.52	23384938
467	Acetylation	PRTPTPFKHALAAQE CCCCCCCHHHHHHCC	29.22	-
476	Acetylation	ALAAQEIKYGPLKML HHHHCCCCCCCCCCC	43.32	-
486	Phosphorylation	PLKMLPQTPSHAVED CCCCCCCCCCHHHHH	25.48	18006338
499	Sumoylation	EDLQDVIKQESDESG HHHHHHHHHHCCCCC	48.11	-
523	Sumoylation	PPLLKKIKQEVESPT CHHHHHHHHHHCCCC	49.65	-
528	Phosphorylation	KIKQEVESPTEKSGN HHHHHHCCCCCCCCC	42.15	17077080
530	Phosphorylation	KQEVESPTEKSGNFF HHHHCCCCCCCCCCC	66.38	25266776
556	Phosphorylation	TQLFSQASPVADAPN HHHHHCCCCCCCCCC	16.57	18006338
572	Phosphorylation	LTSSVLMTPVSEDED CCCCEEECCCCCCCC	19.17	18006338

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
11	S	Phosphorylation	Kinase	CSNK2A1	Q60737	GPS
12	S	Phosphorylation	Kinase	CSNK2A1	Q60737	GPS
486	T	Phosphorylation	Kinase	MAPK14	Q16539	GPS
572	T	Phosphorylation	Kinase	GSK3B	P49841	PSP
572	T	Phosphorylation	Kinase	GSK3B	Q9WV60	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	Fbxw7	Q8VBV4	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	Siah1a	P61092	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYB_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZN292_MOUSE	Zfp292	physical	20211142
TIF1B_MOUSE	Trim28	physical	14761981
PAX5_MOUSE	Pax5	physical	12244173
LEF1_MOUSE	Lef1	physical	12244173
CNOT9_MOUSE	Rqcd1	physical	15209511
PIN1_HUMAN	PIN1	physical	18359295

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.