RAB4B_HUMAN - dbPTM
RAB4B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RAB4B_HUMAN
UniProt AC P61018
Protein Name Ras-related protein Rab-4B
Gene Name RAB4B
Organism Homo sapiens (Human).
Sequence Length 213
Subcellular Localization Cell membrane
Lipid-anchor
Cytoplasmic side .
Protein Description Protein transport. Probably involved in vesicular traffic (By similarity)..
Protein Sequence MAETYDFLFKFLVIGSAGTGKSCLLHQFIENKFKQDSNHTIGVEFGSRVVNVGGKTVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNSLAAWLTDARTLASPNIVVILCGNKKDLDPEREVTFLEASRFAQENELMFLETSALTGENVEEAFLKCARTILNKIDSGELDPERMGSGIQYGDASLRQLRQPRSAQAVAPQPCGC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAETYDFLF
------CCCCHHHHE		20.1722223895
2 (in isoform 2)Phosphorylation-20.1724043423
4 (in isoform 2)Phosphorylation-20.8924043423
8 (in isoform 2)Phosphorylation-4.1024043423
23S-nitrosylationSAGTGKSCLLHQFIE
CCCCCHHHHHHHHHH		5.5124105792
58AcetylationNVGGKTVKLQIWDTA
EECCEEEEEEEECCC		39.6525953088
58UbiquitinationNVGGKTVKLQIWDTA
EECCEEEEEEEECCC		39.65-
64PhosphorylationVKLQIWDTAGQERFR
EEEEEECCCCHHHHH		20.0728857561
67SerotonylationQIWDTAGQERFRSVT
EEECCCCHHHHHHHH		35.91-
119S-nitrosylationPNIVVILCGNKKDLD
CCEEEEECCCCCCCC		3.7624105792
123UbiquitinationVILCGNKKDLDPERE
EEECCCCCCCCHHHH		68.47-
132PhosphorylationLDPEREVTFLEASRF
CCHHHHHHHHHHHHH		20.11-
137PhosphorylationEVTFLEASRFAQENE
HHHHHHHHHHHHHCC		20.68-
172UbiquitinationCARTILNKIDSGELD
HHHHHHHHCCCCCCC		44.43-
185PhosphorylationLDPERMGSGIQYGDA
CCHHHCCCCCCCCCH		24.3123186163
189PhosphorylationRMGSGIQYGDASLRQ
HCCCCCCCCCHHHHH		18.3028060719
193PhosphorylationGIQYGDASLRQLRQP
CCCCCCHHHHHHCCC		28.9123401153
207 (in isoform 2)Ubiquitination-10.46-
211GeranylgeranylationQAVAPQPCGC-----
CCCCCCCCCC-----		7.97-
213MethylationVAPQPCGC-------
CCCCCCCC-------		6.85-
213GeranylgeranylationVAPQPCGC-------
CCCCCCCC-------		6.85-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RAB4B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RAB4B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RAB4B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NSF_HUMANNSFphysical
26496610
PRDX1_HUMANPRDX1physical
26496610
SKIV2_HUMANSKIV2Lphysical
26496610
TAF11_HUMANTAF11physical
26496610
PRPF3_HUMANPRPF3physical
26496610
U520_HUMANSNRNP200physical
26496610
PRP6_HUMANPRPF6physical
26496610
NECP1_HUMANNECAP1physical
26496610
RAB14_HUMANRAB14physical
26496610
CHD8_HUMANCHD8physical
26496610
TFB2M_HUMANTFB2Mphysical
26496610
RHG39_HUMANARHGAP39physical
26496610
RN170_HUMANRNF170physical
26496610
SFXN3_HUMANSFXN3physical
26496610
DAB2P_HUMANDAB2IPphysical
26496610
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RAB4B_HUMAN

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Related Literatures of Post-Translational Modification

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