dbPTM

IF4E3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IF4E3_HUMAN
UniProt AC	Q8N5X7
Protein Name	Eukaryotic translation initiation factor 4E type 3
Gene Name	EIF4E3
Organism	Homo sapiens (Human).
Sequence Length	224
Subcellular Localization
Protein Description	Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity (By similarity)..
Protein Sequence	MALPPAAAPPAGAREPPGSRAAAAAAAPEPPLGLQQLSALQPEPGGVPLHSSWTFWLDRSLPGATAAECASNLKKIYTVQTVQIFWSVYNNIPPVTSLPLRCSYHLMRGERRPLWEEESNAKGGVWKMKVPKDSTSTVWKELLLATIGEQFTDCAAADDEVIGVSVSVRDREDVVQVWNVNASLVGEATVLEKIYELLPHITFKAVFYKPHEEHHAFEGGRGKH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
97	Phosphorylation	NNIPPVTSLPLRCSY CCCCCCCCCCEEEEH	28.37	24719451
129	Acetylation	KGGVWKMKVPKDSTS CCCEEEEECCCCCHH	52.22	30586295
136	Phosphorylation	KVPKDSTSTVWKELL ECCCCCHHHHHHHHH	25.56	22210691
152	Phosphorylation	ATIGEQFTDCAAADD HHHHHHHHHHHHCCC	29.84	22210691
167	Phosphorylation	EVIGVSVSVRDREDV CEEEEEEEECCHHHC	12.15	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of IF4E3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IF4E3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IF4E3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBCD4_HUMAN	TBC1D4	physical	26186194
THMS2_HUMAN	THEMIS2	physical	26186194
THMS2_HUMAN	THEMIS2	physical	28514442
TBCD4_HUMAN	TBC1D4	physical	28514442

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IF4E3_HUMAN

Related Literatures of Post-Translational Modification