| UniProt ID | RERG_HUMAN | |
|---|---|---|
| UniProt AC | Q96A58 | |
| Protein Name | Ras-related and estrogen-regulated growth inhibitor | |
| Gene Name | RERG | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 199 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.. | |
| Protein Sequence | MAKSAEVKLAIFGRAGVGKSALVVRFLTKRFIWEYDPTLESTYRHQATIDDEVVSMEILDTAGQEDTIQREGHMRWGEGFVLVYDITDRGSFEEVLPLKNILDEIKKPKNVTLILVGNKADLDHSRQVSTEEGEKLATELACAFYECSACTGEGNITEIFYELCREVRRRRMVQGKTRRRSSTTHVKQAINKMLTKISS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 84 | Phosphorylation | GEGFVLVYDITDRGS CCEEEEEEECCCCCC | 9.47 | - | |
| 87 | Phosphorylation | FVLVYDITDRGSFEE EEEEEECCCCCCHHH | 19.42 | - | |
| 106 | Ubiquitination | KNILDEIKKPKNVTL HHHHHHCCCCCCEEE | 62.06 | - | |
| 112 | Phosphorylation | IKKPKNVTLILVGNK CCCCCCEEEEEECCC | 19.92 | - | |
| 177 | Phosphorylation | RRMVQGKTRRRSSTT HHHHCCCCCCCCCHH | 35.91 | 17924679 | |
| 181 | Phosphorylation | QGKTRRRSSTTHVKQ CCCCCCCCCHHHHHH | 30.17 | 22798277 | |
| 182 | Phosphorylation | GKTRRRSSTTHVKQA CCCCCCCCHHHHHHH | 35.20 | 26657352 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RERG_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RERG_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RERG_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ARHGH_HUMAN | ARHGEF17 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-177, AND MASSSPECTROMETRY. | |
