OPHN1_HUMAN - dbPTM
OPHN1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID OPHN1_HUMAN
UniProt AC O60890
Protein Name Oligophrenin-1
Gene Name OPHN1
Organism Homo sapiens (Human).
Sequence Length 802
Subcellular Localization Cell junction, synapse. Cell projection, axon. Cell projection, dendritic spine. Cell projection, dendrite. Cytoplasm. Present in both presynaptic and postsynaptic sites..
Protein Description Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity)..
Protein Sequence MGHPPLEFSDCYLDSPDFRERLKCYEQELERTNKFIKDVIKDGNALISAMRNYSSAVQKFSQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPLENFRKEQIGFTKERKKKFEKDGERFYSLLDRHLHLSSKKKESQLQEADLQVDKERHNFFESSLDYVYQIQEVQESKKFNIVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFSSTREEMEELKKRMKEAPQTCKLPGQPTIEGYLYTQEKWALGISWVKYYCQYEKETKTLTMTPMEQKPGAKQGPLDLTLKYCVRRKTESIDKRFCFDIETNERPGTITLQALSEANRRLWMEAMDGKEPIYHSPITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMMNIKFQNIVVEILIEHFGKIYLGPPEESAAPPVPPPRVTARRHKPITISKRLLRERTVFYTSSLDESEDEIQHQTPNGTITSSIEPPKPPQHPKLPIQRSGETDPGRKSPSRPILDGKLEPCPEVDVGKLVSRLQDGGTKITPKATNGPMPGSGPTKTPSFHIKRPAPRPLAHHKEGDADSFSKVRPPGEKPTIIRPPVRPPDPPCRAATPQKPEPKPDIVAGNAGEITSSVVASRTRFFETASRKTGSSQGRLPGDES
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
37AcetylationERTNKFIKDVIKDGN
HHHHHHHHHHHHHCH		49.4225825284
53PhosphorylationLISAMRNYSSAVQKF
HHHHHHCHHHHHHHH		8.1429759185
54PhosphorylationISAMRNYSSAVQKFS
HHHHHCHHHHHHHHH		18.5129759185
55PhosphorylationSAMRNYSSAVQKFSQ
HHHHCHHHHHHHHHH		23.3129759185
121UbiquitinationKPLENFRKEQIGFTK
HHHHHHCHHHCCCCH		50.2429967540
142PhosphorylationEKDGERFYSLLDRHL
HHHHHHHHHHHHHHH		12.4827642862
143PhosphorylationKDGERFYSLLDRHLH
HHHHHHHHHHHHHHH		21.5328857561
370PhosphorylationMDGKEPIYHSPITKQ
HCCCCCCCCCCCCHH		13.6321945579
372PhosphorylationGKEPIYHSPITKQQE
CCCCCCCCCCCHHHC		10.8821945579
375PhosphorylationPIYHSPITKQQEMEL
CCCCCCCCHHHCCHH		26.6121945579
413PhosphorylationGLYRTVGSNIQVQKL
CCCCCCCCCHHHHHH		26.8227499020
480PhosphorylationAKSDNLDYRLGAIHS
HHHCCHHHHHHHHHH		15.76-
522PhosphorylationKENLMTPSNMGVIFG
HHHCCCHHHCCCCCC		30.2225690035
531PhosphorylationMGVIFGPTLMRAQED
CCCCCCHHHHCCCHH		33.30-
605PhosphorylationERTVFYTSSLDESED
HCEEEEECCCCCCHH		19.9528348404
606PhosphorylationRTVFYTSSLDESEDE
CEEEEECCCCCCHHH		31.8528348404
610PhosphorylationYTSSLDESEDEIQHQ
EECCCCCCHHHHCCC		50.4428348404
618PhosphorylationEDEIQHQTPNGTITS
HHHHCCCCCCCCCCC		19.3228348404
643PhosphorylationPKLPIQRSGETDPGR
CCCCCCCCCCCCCCC		25.3023186163
646PhosphorylationPIQRSGETDPGRKSP
CCCCCCCCCCCCCCC		51.5223186163
652PhosphorylationETDPGRKSPSRPILD
CCCCCCCCCCCCCCC		27.0930266825
654PhosphorylationDPGRKSPSRPILDGK
CCCCCCCCCCCCCCC		58.7530266825
685PhosphorylationQDGGTKITPKATNGP
CCCCCCCCCCCCCCC		21.9425159151
696PhosphorylationTNGPMPGSGPTKTPS
CCCCCCCCCCCCCCC		35.4125159151
701PhosphorylationPGSGPTKTPSFHIKR
CCCCCCCCCCEEECC		27.0028060719
703PhosphorylationSGPTKTPSFHIKRPA
CCCCCCCCEEECCCC		34.3922617229
724PhosphorylationHKEGDADSFSKVRPP
CCCCCCCCCCCCCCC		32.8924719451
753PhosphorylationDPPCRAATPQKPEPK
CCCCCCCCCCCCCCC		25.8522617229
787PhosphorylationTRFFETASRKTGSSQ
CCEEEECCCCCCCCC		41.5527535140
792PhosphorylationTASRKTGSSQGRLPG
ECCCCCCCCCCCCCC		25.3928348404
802PhosphorylationGRLPGDES-------
CCCCCCCC-------		50.7027251275
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of OPHN1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of OPHN1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of OPHN1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RHOA_HUMANRHOAphysical
9582072
RAC1_HUMANRAC1physical
9582072
CDC42_HUMANCDC42physical
9582072
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
300486Mental retardation, X-linked, syndromic, OPHN1-related (MRXSO)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of OPHN1_HUMAN

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Related Literatures of Post-Translational Modification

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