| UniProt ID | FLVC2_HUMAN | |
|---|---|---|
| UniProt AC | Q9UPI3 | |
| Protein Name | Feline leukemia virus subgroup C receptor-related protein 2 | |
| Gene Name | FLVCR2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 526 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein. |
|
| Protein Description | Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism.. | |
| Protein Sequence | MVNEGPNQEESDDTPVPESALQADPSVSVHPSVSVHPSVSINPSVSVHPSSSAHPSALAQPSGLAHPSSSGPEDLSVIKVSRRRWAVVLVFSCYSMCNSFQWIQYGSINNIFMHFYGVSAFAIDWLSMCYMLTYIPLLLPVAWLLEKFGLRTIALTGSALNCLGAWVKLGSLKPHLFPVTVVGQLICSVAQVFILGMPSRIASVWFGANEVSTACSVAVFGNQLGIAIGFLVPPVLVPNIEDRDELAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSLSYALTSPDASYLGSIARLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRSKTYKETTLVVYIMTLVGMVVYTFTLNLGHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTISQGQIIDNYGTKPGNIFLCVFLTLGAALTAFIKADLRRQKANKETLENKLQEEEEESNTSKVPTAVSEDHL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 285 | Phosphorylation | YPPSRAQSLSYALTS CCCCHHHHHHHHHHC | 20.49 | - | |
| 299 | Ubiquitination | SPDASYLGSIARLFK CCCHHHHHHHHHHHH | 14.58 | 33845483 | |
| 311 | Ubiquitination | LFKNLNFVLLVITYG HHHHCCEEEEEHHCC | 3.83 | 29901268 | |
| 364 | Phosphorylation | GMLGAVISGIWLDRS HHHHHHHHEEEECCC | 20.02 | - | |
| 500 | Phosphorylation | RQKANKETLENKLQE HHHHCHHHHHHHHHH | 40.77 | - | |
| 504 | Ubiquitination | NKETLENKLQEEEEE CHHHHHHHHHHHHHH | 42.02 | 33845483 | |
| 512 | Phosphorylation | LQEEEEESNTSKVPT HHHHHHHHCCCCCCC | 49.00 | 21815630 | |
| 514 | Phosphorylation | EEEEESNTSKVPTAV HHHHHHCCCCCCCCC | 38.92 | 25159151 | |
| 515 | Phosphorylation | EEEESNTSKVPTAVS HHHHHCCCCCCCCCC | 35.59 | 29255136 | |
| 516 | Ubiquitination | EEESNTSKVPTAVSE HHHHCCCCCCCCCCC | 50.63 | 29901268 | |
| 522 | Phosphorylation | SKVPTAVSEDHL--- CCCCCCCCCCCC--- | 34.54 | 26471730 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FLVC2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FLVC2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FLVC2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| EPN1_HUMAN | EPN1 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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