AT7L2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AT7L2_HUMAN
• UniProt AC: Q5T6C5
• Protein Name: Ataxin-7-like protein 2
• Gene Name: ATXN7L2
• Organism: Homo sapiens (Human).
• Sequence Length: 722
• Protein Sequence: MAVRERAAAAMAALERRVPSLDDFAGQSWSSWVERADLPAADGAELEESSKNTKKLDAMTLIKEDMSIFGHCPAHDDFYLVVCNHCSQVVKPQAFQKHCERRHGPLSKLYGRAPPPPPAPASSQKCHVVNGQGPACRAPGSTKTSSREKGQGSRSRGHQPPEKTQKDNLCQPGGLTKDSPGKPPMAPPSKEPPGRENIEIIPSEGSSHWAEGSPPEKEPSGTRLPPKTHRKMARKECDLNRQCGVINPETKKICTRLLTCKIHSVHQRREVQGRAKDFDVLVAELKANSRKGESPKEKSPGRKEQVLERPSQELPSSVQVVAAVAAPSSTFSVRAKQTYPYCALPRSRASSESELDDEGPCGGDGDPGLFPFPMPRGGTQASSEESEEEGTSDDLHPPPDCHYATRPPRPQAFCTFGSRLVSPGCYVFSRRLDRFCSALSSMLERHLSTHMWKKIPPAAEPPAHLVNSPLSAPLSPSSTGTCPRLPGPTLRPACPASMPPTKDNLVPSYPAGSPSVAAACSQAECMGGSQAITSPLPANTPSPSFSKLPPSKASKSSKGKDGVEVEAPSRKRKLSPGPTTLKRTCILEPTGKGKPSGCRGLSAKTKTALSMGLNGTMGPRVKRAGPLDCRGSPHQLPTPVKASQLENRGAAGHPAKALPTNCLSEEEVAKKRKNLATYCRPVKAKHCQAGAPADVACSVRRKKPGPALAFEEKCSTLKSKAH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	ALERRVPSLDDFAGQ HHHHHCCCHHHHCCC	41.39	27251275
51	Ubiquitination	AELEESSKNTKKLDA CCHHHHHCCCCHHHH	77.30	29967540
122	Phosphorylation	PPPPAPASSQKCHVV CCCCCCCCCCCCEEE	32.04	29396449
123	Phosphorylation	PPPAPASSQKCHVVN CCCCCCCCCCCEEEC	35.45	29396449
125	Acetylation	PAPASSQKCHVVNGQ CCCCCCCCCEEECCC	28.40	26051181
179	Phosphorylation	PGGLTKDSPGKPPMA CCCCCCCCCCCCCCC	36.79	28985074
190	Acetylation	PPMAPPSKEPPGREN CCCCCCCCCCCCCCC	78.86	26051181
203	Phosphorylation	ENIEIIPSEGSSHWA CCEEECCCCCCCCCC	44.15	27080861
206	Phosphorylation	EIIPSEGSSHWAEGS EECCCCCCCCCCCCC	18.25	27080861
207	Phosphorylation	IIPSEGSSHWAEGSP ECCCCCCCCCCCCCC	33.63	27080861
213	Phosphorylation	SSHWAEGSPPEKEPS CCCCCCCCCCCCCCC	28.87	28387310
220	Phosphorylation	SPPEKEPSGTRLPPK CCCCCCCCCCCCCCH	54.62	27080861
222	Phosphorylation	PEKEPSGTRLPPKTH CCCCCCCCCCCCHHH	33.11	27080861
311	Phosphorylation	EQVLERPSQELPSSV HHHHHCCCCCCCCCC	42.37	28258704
316	Phosphorylation	RPSQELPSSVQVVAA CCCCCCCCCCEEEEE	56.62	28258704
328	Phosphorylation	VAAVAAPSSTFSVRA EEEEECCCCCEEEEE	36.97	28258704
338	Phosphorylation	FSVRAKQTYPYCALP EEEEECCCCCCCCCC	26.25	23532336
347	Phosphorylation	PYCALPRSRASSESE CCCCCCCCCCCCCCC	30.20	24144214
350	Phosphorylation	ALPRSRASSESELDD CCCCCCCCCCCCCCC	33.26	24144214
351	Phosphorylation	LPRSRASSESELDDE CCCCCCCCCCCCCCC	44.12	24144214
353	Phosphorylation	RSRASSESELDDEGP CCCCCCCCCCCCCCC	45.46	24144214
379	Phosphorylation	FPMPRGGTQASSEES CCCCCCCCCCCCHHH	24.64	23898821
382	Phosphorylation	PRGGTQASSEESEEE CCCCCCCCCHHHHCC	28.59	23898821
383	Phosphorylation	RGGTQASSEESEEEG CCCCCCCCHHHHCCC	48.69	23898821
386	Phosphorylation	TQASSEESEEEGTSD CCCCCHHHHCCCCCC	46.38	23898821
422	Phosphorylation	TFGSRLVSPGCYVFS ECCCEEECCCCCHHH	21.84	28555341
440	Phosphorylation	DRFCSALSSMLERHL HHHHHHHHHHHHHHH	17.26	-
468	Phosphorylation	PPAHLVNSPLSAPLS CCHHCCCCCCCCCCC	21.53	25850435
471	Phosphorylation	HLVNSPLSAPLSPSS HCCCCCCCCCCCCCC	31.09	25850435
475	Phosphorylation	SPLSAPLSPSSTGTC CCCCCCCCCCCCCCC	22.98	30576142
477	Phosphorylation	LSAPLSPSSTGTCPR CCCCCCCCCCCCCCC	36.84	25850435
478	Phosphorylation	SAPLSPSSTGTCPRL CCCCCCCCCCCCCCC	33.95	25850435
479	Phosphorylation	APLSPSSTGTCPRLP CCCCCCCCCCCCCCC	40.63	25850435
481	Phosphorylation	LSPSSTGTCPRLPGP CCCCCCCCCCCCCCC	21.30	25850435
534	Phosphorylation	GGSQAITSPLPANTP CCCCCCCCCCCCCCC	20.51	23879269
542	Phosphorylation	PLPANTPSPSFSKLP CCCCCCCCCCHHHCC	31.01	23879269
544	Phosphorylation	PANTPSPSFSKLPPS CCCCCCCCHHHCCCC	46.63	24719451
546	Phosphorylation	NTPSPSFSKLPPSKA CCCCCCHHHCCCCCC	37.31	23879269
551	Phosphorylation	SFSKLPPSKASKSSK CHHHCCCCCCCCCCC	38.62	24732914
554	Phosphorylation	KLPPSKASKSSKGKD HCCCCCCCCCCCCCC	36.49	24732914
556	Phosphorylation	PPSKASKSSKGKDGV CCCCCCCCCCCCCCC	34.48	24732914
557	Phosphorylation	PSKASKSSKGKDGVE CCCCCCCCCCCCCCE	49.52	24732914
560	Acetylation	ASKSSKGKDGVEVEA CCCCCCCCCCCEECC	55.86	20167786
571	Acetylation	EVEAPSRKRKLSPGP EECCCCCCCCCCCCC	59.22	20167786
575	Phosphorylation	PSRKRKLSPGPTTLK CCCCCCCCCCCCCCE	30.74	29255136
579	Phosphorylation	RKLSPGPTTLKRTCI CCCCCCCCCCEEEEE	51.15	23927012
580	Phosphorylation	KLSPGPTTLKRTCIL CCCCCCCCCEEEEEE	33.15	23927012
616	Phosphorylation	LSMGLNGTMGPRVKR HHCCCCCCCCCCCCC	20.20	27135362
632	Phosphorylation	GPLDCRGSPHQLPTP CCCCCCCCCCCCCCC	10.39	25159151
638	Phosphorylation	GSPHQLPTPVKASQL CCCCCCCCCCCHHHH	49.67	26055452
656	Acetylation	GAAGHPAKALPTNCL CCCCCCCCCCCCCCC	55.71	26051181

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AT7L2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AT7L2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AT7L2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MDFI_HUMAN	MDFI	physical	16713569
CBX3_HUMAN	CBX3	physical	16713569
LAMB1_HUMAN	LAMB1	physical	16713569
P2R3A_HUMAN	PPP2R3A	physical	16713569

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.