TTL_HUMAN - dbPTM
TTL_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TTL_HUMAN
UniProt AC Q8NG68
Protein Name Tubulin--tyrosine ligase
Gene Name TTL
Organism Homo sapiens (Human).
Sequence Length 377
Subcellular Localization
Protein Description Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin..
Protein Sequence MYTFVVRDENSSVYAEVSRLLLATGHWKRLRRDNPRFNLMLGERNRLPFGRLGHEPGLVQLVNYYRGADKLCRKASLVKLIKTSPELAESCTWFPESYVIYPTNLKTPVAPAQNGIQPPISNSRTDEREFFLASYNRKKEDGEGNVWIAKSSAGAKGEGILISSEASELLDFIDNQGQVHVIQKYLEHPLLLEPGHRKFDIRSWVLVDHQYNIYLYREGVLRTASEPYHVDNFQDKTCHLTNHCIQKEYSKNYGKYEEGNEMFFKEFNQYLTSALNITLESSILLQIKHIIRNCLLSVEPAISTKHLPYQSFQLFGFDFMVDEELKVWLIEVNGAPACAQKLYAELCQGIVDIAISSVFPPPDVEQPQTQPAAFIKL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MYTFVVRDEN
-----CEEEEECCCC		14.5126503514
18PhosphorylationSSVYAEVSRLLLATG
CHHHHHHHHHHHHHC		14.55-
24PhosphorylationVSRLLLATGHWKRLR
HHHHHHHHCHHHHHH		29.55-
76PhosphorylationDKLCRKASLVKLIKT
HHHHHHHHHHHHHHC		36.4124719451
79UbiquitinationCRKASLVKLIKTSPE
HHHHHHHHHHHCCHH		50.1927667366
107PhosphorylationIYPTNLKTPVAPAQN
EEECCCCCCCCCCCC		26.6028555341
135PhosphorylationREFFLASYNRKKEDG
HHEEHHHCCCCCCCC		17.2422817900
138AcetylationFLASYNRKKEDGEGN
EHHHCCCCCCCCCCC		57.8012437925
150AcetylationEGNVWIAKSSAGAKG
CCCEEEEECCCCCCC		35.497481465
150UbiquitinationEGNVWIAKSSAGAKG
CCCEEEEECCCCCCC		35.4929967540
251UbiquitinationCIQKEYSKNYGKYEE
HHHHHHHHHCCCCCC		53.9727667366
343PhosphorylationPACAQKLYAELCQGI
CHHHHHHHHHHHHHH		12.6923403867
356PhosphorylationGIVDIAISSVFPPPD
HHHHHHHHCCCCCCC		16.0723403867
357PhosphorylationIVDIAISSVFPPPDV
HHHHHHHCCCCCCCC		22.9723403867
369PhosphorylationPDVEQPQTQPAAFIK
CCCCCCCCCCCCEEE		43.1123403867
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TTL_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TTL_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TTL_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TTL_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TTL_HUMAN

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Related Literatures of Post-Translational Modification

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