EVC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EVC_HUMAN
• UniProt AC: P57679
• Protein Name: Ellis-van Creveld syndrome protein
• Gene Name: EVC
• Organism: Homo sapiens (Human).
• Sequence Length: 992
• Subcellular Localization: Cell membrane ; Single-pass membrane protein . Cytoplasm, cytoskeleton, cilium basal body . Cell projection, cilium . Cell projection, cilium membrane . EVC2 is required for the localization of EVC at the base of primary cilia. The EvC complex locali
• Protein Description: Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development..
• Protein Sequence: MARGGAACKSDARLLLGRDALRPAPALLAPAVLLGAALGLGLGLWLGCRAGRQRTRHQKDDTQNLLKNLESNAQTPSETGSPSRRRKREVQMSKDKEAVDECEPPSNSNITAFALKAKVIYPINQKFRPLADGSSNPSLHENLKQAVLPHQPVEASPSSSLGSLSQGEKDDCSSSSSVHSATSDDRFLSRTFLRVNAFPEVLACESVDVDLCIYSLHLKDLLHLDTALRQEKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEEENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLLEKPLRTKRKKPLPQERGDLGVPNNEDLASGDQTSGSLSSKRLSQQESEAGDSGNSKKMLKRRSNL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	RGGAACKSDARLLLG CCCCCCHHHHHHHCC	36.06	29083192
55	Phosphorylation	CRAGRQRTRHQKDDT HHHCCCCCCCCCHHH	24.94	23403867
62	Phosphorylation	TRHQKDDTQNLLKNL CCCCCHHHHHHHHHH	29.50	23403867
71	Phosphorylation	NLLKNLESNAQTPSE HHHHHHHHHCCCCCC	40.40	23927012
75	Phosphorylation	NLESNAQTPSETGSP HHHHHCCCCCCCCCH	26.77	23927012
77	Phosphorylation	ESNAQTPSETGSPSR HHHCCCCCCCCCHHH	51.70	29255136
79	Phosphorylation	NAQTPSETGSPSRRR HCCCCCCCCCHHHHH	47.50	29255136
81	Phosphorylation	QTPSETGSPSRRRKR CCCCCCCCHHHHHHH	27.41	23403867
83	Phosphorylation	PSETGSPSRRRKREV CCCCCCHHHHHHHHH	39.87	25850435
135	Phosphorylation	RPLADGSSNPSLHEN CCCCCCCCCCCHHHH	59.29	24961811
138	Phosphorylation	ADGSSNPSLHENLKQ CCCCCCCCHHHHHHH	46.76	25056879
180	Phosphorylation	SSSSSVHSATSDDRF CCCCCCCCCCCCCCH	30.96	-
182	Phosphorylation	SSSVHSATSDDRFLS CCCCCCCCCCCCHHH	35.39	-
286	Phosphorylation	KLSNTEMSGAGDSEY EECCCCCCCCCCCCE	21.18	21130716
418	Ubiquitination	GKLSGRQKEELLTQQ CCCCHHHHHHHHHHH	52.36	-
423	Phosphorylation	RQKEELLTQQHKAFW HHHHHHHHHHHHHHH	38.52	22210691
449	Phosphorylation	QRGKDLVTASLAHQV HCCHHHHHHHHHHHH	20.16	24505115
717	Phosphorylation	LEEEAQQTRLQLQQR HHHHHHHHHHHHHHH	22.67	-
956	Phosphorylation	PNNEDLASGDQTSGS CCCCHHCCCCCCCCC	50.64	22210691
963	Phosphorylation	SGDQTSGSLSSKRLS CCCCCCCCCCHHCHH	25.50	22210691
965	Phosphorylation	DQTSGSLSSKRLSQQ CCCCCCCCHHCHHHH	35.20	22210691
970	Phosphorylation	SLSSKRLSQQESEAG CCCHHCHHHHHHHCC	33.57	29255136

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EVC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EVC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EVC_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of EVC_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.