AT10D_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AT10D_HUMAN
• UniProt AC: Q9P241
• Protein Name: Probable phospholipid-transporting ATPase VD
• Gene Name: ATP10D
• Organism: Homo sapiens (Human).
• Sequence Length: 1426
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane . Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B.
• Protein Description: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable)..
• Protein Sequence: MTEALQWARYHWRRLIRGATRDDDSGPYNYSSLLACGRKSSQTPKLSGRHRIVVPHIQPFKDEYEKFSGAYVNNRIRTTKYTLLNFVPRNLFEQFHRAANLYFLFLVVLNWVPLVEAFQKEITMLPLVVVLTIIAIKDGLEDYRKYKIDKQINNLITKVYSRKEKKYIDRCWKDVTVGDFIRLSCNEVIPADMVLLFSTDPDGICHIETSGLDGESNLKQRQVVRGYAEQDSEVDPEKFSSRIECESPNNDLSRFRGFLEHSNKERVGLSKENLLLRGCTIRNTEAVVGIVVYAGHETKAMLNNSGPRYKRSKLERRANTDVLWCVMLLVIMCLTGAVGHGIWLSRYEKMHFFNVPEPDGHIISPLLAGFYMFWTMIILLQVLIPISLYVSIEIVKLGQIYFIQSDVDFYNEKMDSIVQCRALNIAEDLGQIQYLFSDKTGTLTENKMVFRRCSVAGFDYCHEENARRLESYQEAVSEDEDFIDTVSGSLSNMAKPRAPSCRTVHNGPLGNKPSNHLAGSSFTLGSGEGASEVPHSRQAAFSSPIETDVVPDTRLLDKFSQITPRLFMPLDETIQNPPMETLYIIDFFIALAICNTVVVSAPNQPRQKIRHPSLGGLPIKSLEEIKSLFQRWSVRRSSSPSLNSGKEPSSGVPNAFVSRLPLFSRMKPASPVEEEVSQVCESPQCSSSSACCTETEKQHGDAGLLNGKAESLPGQPLACNLCYEAESPDEAALVYAARAYQCTLRSRTPEQVMVDFAALGPLTFQLLHILPFDSVRKRMSVVVRHPLSNQVVVYTKGADSVIMELLSVASPDGASLEKQQMIVREKTQKHLDDYAKQGLRTLCIAKKVMSDTEYAEWLRNHFLAETSIDNREELLLESAMRLENKLTLLGATGIEDRLQEGVPESIEALHKAGIKIWMLTGDKQETAVNIAYACKLLEPDDKLFILNTQSKDACGMLMSTILKELQKKTQALPEQVSLSEDLLQPPVPRDSGLRAGLIITGKTLEFALQESLQKQFLELTSWCQAVVCCRATPLQKSEVVKLVRSHLQVMTLAIGDGANDVSMIQVADIGIGVSGQEGMQAVMASDFAVSQFKHLSKLLLVHGHWCYTRLSNMILYFFYKNVAYVNLLFWYQFFCGFSGTSMTDYWVLIFFNLLFTSAPPVIYGVLEKDVSAETLMQLPELYRSGQKSEAYLPHTFWITLLDAFYQSLVCFFVPYFTYQGSDTDIFAFGNPLNTAALFIVLLHLVIESKSLTWIHLLVIIGSILSYFLFAIVFGAMCVTCNPPSNPYWIMQEHMLDPVFYLVCILTTSIALLPRFVYRVLQGSLFPSPILRAKHFDRLTPEERTKALKKWRGAGKMNQVTSKYANQSAGKSGRRPMPGPSAVFAMKSASSCAIEQGNLSLCETALDQGYSETKAFEMAGPSKGKES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTEALQWAR ------CCHHHHHHH	41.07	26074081
40	Phosphorylation	LLACGRKSSQTPKLS HHHCCCCCCCCCCCC	26.73	-
41	Phosphorylation	LACGRKSSQTPKLSG HHCCCCCCCCCCCCC	40.90	-
43	Phosphorylation	CGRKSSQTPKLSGRH CCCCCCCCCCCCCCC	25.08	-
47	Phosphorylation	SSQTPKLSGRHRIVV CCCCCCCCCCCEEEE	39.65	-
78	Phosphorylation	YVNNRIRTTKYTLLN CCCCCHHCCCCHHHH	25.85	-
79	Phosphorylation	VNNRIRTTKYTLLNF CCCCHHCCCCHHHHC	16.53	-
167	Phosphorylation	YSRKEKKYIDRCWKD HHHCCHHHHHHHCCC	21.08	29457462
238	Ubiquitination	DSEVDPEKFSSRIEC CCCCCHHHHHCCEEE	56.80	29967540
264	Ubiquitination	GFLEHSNKERVGLSK HHHHHCCCCCCCCCH	50.33	29967540
305	Phosphorylation	TKAMLNNSGPRYKRS HHHHHHCCCHHHHHH	49.45	-
309	Phosphorylation	LNNSGPRYKRSKLER HHCCCHHHHHHHHHH	17.56	-
416	Phosphorylation	FYNEKMDSIVQCRAL CCHHCCCHHHHHHHH	22.59	29083192
450	Ubiquitination	LTENKMVFRRCSVAG CCCCCCHHHHHCCCC	3.50	21890473
471	Phosphorylation	ENARRLESYQEAVSE HHHHHHHHHHHHHHC	36.39	22199227
472	Phosphorylation	NARRLESYQEAVSED HHHHHHHHHHHHHCC	10.86	22199227
477	Phosphorylation	ESYQEAVSEDEDFID HHHHHHHHCCCCHHH	46.51	22199227
485	Phosphorylation	EDEDFIDTVSGSLSN CCCCHHHHHCHHHHH	16.26	29759185
613	Phosphorylation	RQKIRHPSLGGLPIK CCCCCCCCCCCCCCC	33.26	30266825
621	Phosphorylation	LGGLPIKSLEEIKSL CCCCCCCCHHHHHHH	41.55	29083192
626	Acetylation	IKSLEEIKSLFQRWS CCCHHHHHHHHHHHH	44.37	20167786
627	Phosphorylation	KSLEEIKSLFQRWSV CCHHHHHHHHHHHHC	39.83	29083192
633	Phosphorylation	KSLFQRWSVRRSSSP HHHHHHHHCCCCCCC	14.13	29083192
637	Phosphorylation	QRWSVRRSSSPSLNS HHHHCCCCCCCCCCC	25.30	28348404
638	Phosphorylation	RWSVRRSSSPSLNSG HHHCCCCCCCCCCCC	44.44	24501219
639	Phosphorylation	WSVRRSSSPSLNSGK HHCCCCCCCCCCCCC	21.54	24501219
641	Phosphorylation	VRRSSSPSLNSGKEP CCCCCCCCCCCCCCC	41.97	28348404
644	Phosphorylation	SSSPSLNSGKEPSSG CCCCCCCCCCCCCCC	57.44	-
747 (in isoform 2)	Ubiquitination	-	48.11	21890473
780	Phosphorylation	DSVRKRMSVVVRHPL CHHHHCEEEEEECCC	18.78	28842319
788	Phosphorylation	VVVRHPLSNQVVVYT EEEECCCCCCEEEEE	29.66	28842319
834	Phosphorylation	TQKHLDDYAKQGLRT HHHHHHHHHHHHHHH	18.50	29759185
836	Ubiquitination	KHLDDYAKQGLRTLC HHHHHHHHHHHHHHH	38.37	29967540
841	Phosphorylation	YAKQGLRTLCIAKKV HHHHHHHHHHHHHHH	30.90	29759185
877	Ubiquitination	NREELLLESAMRLEN CHHHHHHHHHHHHHH	36.10	21890473
927	Ubiquitination	TGDKQETAVNIAYAC CCCCHHHHHHHHHHH	7.51	21890473
942	Ubiquitination	KLLEPDDKLFILNTQ HHCCCCCCEEEEECC	53.31	21890473
942 (in isoform 1)	Ubiquitination	-	53.31	21890473
942	Ubiquitination	KLLEPDDKLFILNTQ HHCCCCCCEEEEECC	53.31	23000965
969	Phosphorylation	LKELQKKTQALPEQV HHHHHHHHCCCCCCC	26.55	30266825
977	Phosphorylation	QALPEQVSLSEDLLQ CCCCCCCCCCHHHHC	26.35	30266825
979	Phosphorylation	LPEQVSLSEDLLQPP CCCCCCCCHHHHCCC	22.89	30266825
991	Phosphorylation	QPPVPRDSGLRAGLI CCCCCCCCCCCEEEE	40.79	-
1361	Phosphorylation	GKMNQVTSKYANQSA CHHHHHHHHHHCCCC	25.47	29759185
1363	Phosphorylation	MNQVTSKYANQSAGK HHHHHHHHHCCCCCC	15.56	29759185
1367	Phosphorylation	TSKYANQSAGKSGRR HHHHHCCCCCCCCCC	38.50	29759185
1371	Phosphorylation	ANQSAGKSGRRPMPG HCCCCCCCCCCCCCC	36.29	-
1399	Phosphorylation	AIEQGNLSLCETALD HHHHCCEEHHHHHHH	34.67	-
1403	Phosphorylation	GNLSLCETALDQGYS CCEEHHHHHHHCCCC	31.37	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AT10D_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AT10D_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AT10D_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of AT10D_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.