UniProt ID | LRAD3_HUMAN | |
---|---|---|
UniProt AC | Q86YD5 | |
Protein Name | Low-density lipoprotein receptor class A domain-containing protein 3 | |
Gene Name | LDLRAD3 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 345 | |
Subcellular Localization |
Cell membrane Single-pass type I membrane protein. |
|
Protein Description | May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production.. | |
Protein Sequence | MWLLGPLCLLLSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLVYYPSITYAIIGSSVIFVLVVALLALVLHHQRKRNNLMTLPVHRLQHPVLLSRLVVLDHPHHCNVTYNVNNGIQYVASQAEQNASEVGSPPSYSEALLDQRPAWYDLPPPPYSSDTESLNQADLPPYRSRSGSANSASSQAASSLLSVEDTSHSPGQPGPQEGTAEPRDSEPSQGTEEV | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
24 | N-linked_Glycosylation | SQLLPGNNFTNECNI HCCCCCCCCCCCCCC | 51.54 | UniProtKB CARBOHYD | |
101 | Phosphorylation | FEDCPDGSDEENCTA CCCCCCCCCCCCCCC | 49.59 | 22210691 | |
271 | Phosphorylation | LDQRPAWYDLPPPPY HCCCCCCCCCCCCCC | 15.09 | 27732954 | |
278 | Phosphorylation | YDLPPPPYSSDTESL CCCCCCCCCCCCCCC | 26.95 | 27732954 | |
279 | Phosphorylation | DLPPPPYSSDTESLN CCCCCCCCCCCCCCC | 27.75 | 27732954 | |
280 | Phosphorylation | LPPPPYSSDTESLNQ CCCCCCCCCCCCCCC | 42.58 | 27732954 | |
282 | Phosphorylation | PPPYSSDTESLNQAD CCCCCCCCCCCCCCC | 29.44 | 27732954 | |
284 | Phosphorylation | PYSSDTESLNQADLP CCCCCCCCCCCCCCC | 34.41 | 27732954 | |
293 | Phosphorylation | NQADLPPYRSRSGSA CCCCCCCCCCCCCCC | 21.20 | 27732954 | |
297 | Phosphorylation | LPPYRSRSGSANSAS CCCCCCCCCCCCCHH | 38.04 | 28450419 | |
299 | Phosphorylation | PYRSRSGSANSASSQ CCCCCCCCCCCHHHH | 26.06 | 28450419 | |
302 | Phosphorylation | SRSGSANSASSQAAS CCCCCCCCHHHHHHH | 29.28 | 28450419 | |
304 | Phosphorylation | SGSANSASSQAASSL CCCCCCHHHHHHHHH | 23.86 | 27251275 | |
305 | Phosphorylation | GSANSASSQAASSLL CCCCCHHHHHHHHHC | 24.45 | 28450419 | |
309 | Phosphorylation | SASSQAASSLLSVED CHHHHHHHHHCCCCC | 25.24 | 27251275 | |
310 | Phosphorylation | ASSQAASSLLSVEDT HHHHHHHHHCCCCCC | 28.71 | 28450419 | |
313 | Phosphorylation | QAASSLLSVEDTSHS HHHHHHCCCCCCCCC | 28.84 | 28450419 | |
317 | Phosphorylation | SLLSVEDTSHSPGQP HHCCCCCCCCCCCCC | 18.16 | 28450419 | |
318 | Phosphorylation | LLSVEDTSHSPGQPG HCCCCCCCCCCCCCC | 34.00 | 28450419 | |
320 | Phosphorylation | SVEDTSHSPGQPGPQ CCCCCCCCCCCCCCC | 30.41 | 28450419 | |
330 | Phosphorylation | QPGPQEGTAEPRDSE CCCCCCCCCCCCCCC | 27.39 | 23312004 | |
339 | Phosphorylation | EPRDSEPSQGTEEV- CCCCCCCCCCCCCC- | 36.87 | 23312004 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LRAD3_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LRAD3_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LRAD3_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
ITCH_MOUSE | Itch | physical | 26854353 | |
ITCH_HUMAN | ITCH | physical | 26854353 | |
NEDD4_MOUSE | Nedd4 | physical | 26854353 | |
DYN1_MOUSE | Dnm1 | physical | 26854353 | |
AT1A3_MOUSE | Atp1a3 | physical | 26854353 |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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