LRAD3_HUMAN - dbPTM
LRAD3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LRAD3_HUMAN
UniProt AC Q86YD5
Protein Name Low-density lipoprotein receptor class A domain-containing protein 3
Gene Name LDLRAD3
Organism Homo sapiens (Human).
Sequence Length 345
Subcellular Localization Cell membrane
Single-pass type I membrane protein.
Protein Description May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production..
Protein Sequence MWLLGPLCLLLSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLVYYPSITYAIIGSSVIFVLVVALLALVLHHQRKRNNLMTLPVHRLQHPVLLSRLVVLDHPHHCNVTYNVNNGIQYVASQAEQNASEVGSPPSYSEALLDQRPAWYDLPPPPYSSDTESLNQADLPPYRSRSGSANSASSQAASSLLSVEDTSHSPGQPGPQEGTAEPRDSEPSQGTEEV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
24N-linked_GlycosylationSQLLPGNNFTNECNI
HCCCCCCCCCCCCCC		51.54UniProtKB CARBOHYD
101PhosphorylationFEDCPDGSDEENCTA
CCCCCCCCCCCCCCC		49.5922210691
271PhosphorylationLDQRPAWYDLPPPPY
HCCCCCCCCCCCCCC		15.0927732954
278PhosphorylationYDLPPPPYSSDTESL
CCCCCCCCCCCCCCC		26.9527732954
279PhosphorylationDLPPPPYSSDTESLN
CCCCCCCCCCCCCCC		27.7527732954
280PhosphorylationLPPPPYSSDTESLNQ
CCCCCCCCCCCCCCC		42.5827732954
282PhosphorylationPPPYSSDTESLNQAD
CCCCCCCCCCCCCCC		29.4427732954
284PhosphorylationPYSSDTESLNQADLP
CCCCCCCCCCCCCCC		34.4127732954
293PhosphorylationNQADLPPYRSRSGSA
CCCCCCCCCCCCCCC		21.2027732954
297PhosphorylationLPPYRSRSGSANSAS
CCCCCCCCCCCCCHH		38.0428450419
299PhosphorylationPYRSRSGSANSASSQ
CCCCCCCCCCCHHHH		26.0628450419
302PhosphorylationSRSGSANSASSQAAS
CCCCCCCCHHHHHHH		29.2828450419
304PhosphorylationSGSANSASSQAASSL
CCCCCCHHHHHHHHH		23.8627251275
305PhosphorylationGSANSASSQAASSLL
CCCCCHHHHHHHHHC		24.4528450419
309PhosphorylationSASSQAASSLLSVED
CHHHHHHHHHCCCCC		25.2427251275
310PhosphorylationASSQAASSLLSVEDT
HHHHHHHHHCCCCCC		28.7128450419
313PhosphorylationQAASSLLSVEDTSHS
HHHHHHCCCCCCCCC		28.8428450419
317PhosphorylationSLLSVEDTSHSPGQP
HHCCCCCCCCCCCCC		18.1628450419
318PhosphorylationLLSVEDTSHSPGQPG
HCCCCCCCCCCCCCC		34.0028450419
320PhosphorylationSVEDTSHSPGQPGPQ
CCCCCCCCCCCCCCC		30.4128450419
330PhosphorylationQPGPQEGTAEPRDSE
CCCCCCCCCCCCCCC		27.3923312004
339PhosphorylationEPRDSEPSQGTEEV-
CCCCCCCCCCCCCC-		36.8723312004
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LRAD3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LRAD3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LRAD3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ITCH_MOUSEItchphysical
26854353
ITCH_HUMANITCHphysical
26854353
NEDD4_MOUSENedd4physical
26854353
DYN1_MOUSEDnm1physical
26854353
AT1A3_MOUSEAtp1a3physical
26854353
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LRAD3_HUMAN

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Related Literatures of Post-Translational Modification

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