DEPD7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DEPD7_HUMAN
• UniProt AC: Q96QD5
• Protein Name: DEP domain-containing protein 7
• Gene Name: DEPDC7
• Organism: Homo sapiens (Human).
• Sequence Length: 511
• Protein Sequence: MATVQEKAAALNLSALHSPAHRPPGFSVAQKPFGATYVWSSIINTLQTQVEVKKRRHRLKRHNDCFVGSEAVDVIFSHLIQNKYFGDVDIPRAKVVRVCQALMDYKVFEAVPTKVFGKDKKPTFEDSSCSLYRFTTIPNQDSQLGKENKLYSPARYADALFKSSDIRSASLEDLWENLSLKPANSPHVNISATLSPQVINEVWQEETIGRLLQLVDLPLLDSLLKQQEAVPKIPQPKRQSTMVNSSNYLDRGILKAYSDSQEDEWLSAAIDCLEYLPDQMVVEISRSFPEQPDRTDLVKELLFDAIGRYYSSREPLLNHLSDVHNGIAELLVNGKTEIALEATQLLLKLLDFQNREEFRRLLYFMAVAANPSEFKLQKESDNRMVVKRIFSKAIVDNKNLSKGKTDLLVLFLMDHQKDVFKIPGTLHKIVSVKLMAIQNGRDPNRDAGYIYCQRIDQRDYSNNTEKTTKDELLNLLKTLDEDSKLSAKEKKKLLGQFYKCHPDIFIEHFGD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MATVQEKAAA -----CCCHHHHHHH	22.79	29888752
14	Phosphorylation	KAAALNLSALHSPAH HHHHHCHHHHCCCCC	27.93	25159151
18	Phosphorylation	LNLSALHSPAHRPPG HCHHHHCCCCCCCCC	25.32	25159151
84	Phosphorylation	SHLIQNKYFGDVDIP HHHHCCCCCCCCCCC	21.97	-
105	Ubiquitination	VCQALMDYKVFEAVP HHHHHHCCHHEECCC	8.62	29967540
111	Ubiquitination	DYKVFEAVPTKVFGK CCHHEECCCCCCCCC	4.94	29967540
112	Ubiquitination	YKVFEAVPTKVFGKD CHHEECCCCCCCCCC	33.28	29967540
114	Ubiquitination	VFEAVPTKVFGKDKK HEECCCCCCCCCCCC	29.51	29967540
120	Ubiquitination	TKVFGKDKKPTFEDS CCCCCCCCCCCCCCC	65.23	29967540
121	Ubiquitination	KVFGKDKKPTFEDSS CCCCCCCCCCCCCCC	60.47	29967540
132	Phosphorylation	EDSSCSLYRFTTIPN CCCCCEEEEEEECCC	6.33	29496907
137	Ubiquitination	SLYRFTTIPNQDSQL EEEEEEECCCCCCCC	2.47	29967540
140	Ubiquitination	RFTTIPNQDSQLGKE EEEECCCCCCCCCCC	46.51	29967540
142	Phosphorylation	TTIPNQDSQLGKENK EECCCCCCCCCCCCC	19.96	27470641
146	Ubiquitination	NQDSQLGKENKLYSP CCCCCCCCCCCCCCH	67.70	29967540
149	Ubiquitination	SQLGKENKLYSPARY CCCCCCCCCCCHHHH	50.31	29967540
151	Phosphorylation	LGKENKLYSPARYAD CCCCCCCCCHHHHHH	17.76	23186163
152	Phosphorylation	GKENKLYSPARYADA CCCCCCCCHHHHHHH	23.63	21815630
156	Phosphorylation	KLYSPARYADALFKS CCCCHHHHHHHHHHC	15.78	29978859
162	Ubiquitination	RYADALFKSSDIRSA HHHHHHHHCCCCCCC	50.31	-
168	Phosphorylation	FKSSDIRSASLEDLW HHCCCCCCCCHHHHH	23.65	29507054
170	Phosphorylation	SSDIRSASLEDLWEN CCCCCCCCHHHHHHH	33.27	25159151
179	Phosphorylation	EDLWENLSLKPANSP HHHHHHHCCCCCCCC	46.02	24719451
185	Phosphorylation	LSLKPANSPHVNISA HCCCCCCCCCCEEEE	20.63	25159151
195	Phosphorylation	VNISATLSPQVINEV CEEEEECCHHHHHHH	14.66	25159151
216	Ubiquitination	GRLLQLVDLPLLDSL HHHHHHHHHHHHHHH	51.68	21987572
222	Phosphorylation	VDLPLLDSLLKQQEA HHHHHHHHHHHCCCC	35.25	24719451
225	Ubiquitination	PLLDSLLKQQEAVPK HHHHHHHHCCCCCCC	56.05	21987572
240	Phosphorylation	IPQPKRQSTMVNSSN CCCCCCCCCCCCCCC	23.62	29978859
241	Phosphorylation	PQPKRQSTMVNSSNY CCCCCCCCCCCCCCC	19.46	25159151
245	Phosphorylation	RQSTMVNSSNYLDRG CCCCCCCCCCCCCHH	14.46	22210691
246	Phosphorylation	QSTMVNSSNYLDRGI CCCCCCCCCCCCHHH	25.04	30619164
248	Phosphorylation	TMVNSSNYLDRGILK CCCCCCCCCCHHHHH	16.36	29978859
383	Ubiquitination	LQKESDNRMVVKRIF CCCCCCCCHHHHHHH	25.02	29967540
389	Ubiquitination	NRMVVKRIFSKAIVD CCHHHHHHHHHHHHC	3.66	29967540
391	Phosphorylation	MVVKRIFSKAIVDNK HHHHHHHHHHHHCCC	20.85	24719451
392	Ubiquitination	VVKRIFSKAIVDNKN HHHHHHHHHHHCCCC	31.23	29967540
398	Ubiquitination	SKAIVDNKNLSKGKT HHHHHCCCCCCCCCC	55.60	29967540
401	Phosphorylation	IVDNKNLSKGKTDLL HHCCCCCCCCCCCHH	49.07	29083192
405	Phosphorylation	KNLSKGKTDLLVLFL CCCCCCCCCHHHHHH	40.31	29083192
412	Ubiquitination	TDLLVLFLMDHQKDV CCHHHHHHHCCCCCC	3.26	29967540
419	Ubiquitination	LMDHQKDVFKIPGTL HHCCCCCCCCCCCHH	7.29	29967540
421	Ubiquitination	DHQKDVFKIPGTLHK CCCCCCCCCCCHHHH	48.08	29967540
428	Ubiquitination	KIPGTLHKIVSVKLM CCCCHHHHHHEEEEE	48.17	29967540
441	Methylation	LMAIQNGRDPNRDAG EEHHHCCCCCCCCCC	64.86	-
445	Methylation	QNGRDPNRDAGYIYC HCCCCCCCCCCEEEE	40.31	-
449	Phosphorylation	DPNRDAGYIYCQRID CCCCCCCEEEEEECC	7.16	25159151
451	Phosphorylation	NRDAGYIYCQRIDQR CCCCCEEEEEECCCC	3.66	25159151
460	Ubiquitination	QRIDQRDYSNNTEKT EECCCCCCCCCCCCC	18.58	29967540
468	Ubiquitination	SNNTEKTTKDELLNL CCCCCCCCHHHHHHH	47.79	29967540
469	Ubiquitination	NNTEKTTKDELLNLL CCCCCCCHHHHHHHH	55.21	29967540
477	Ubiquitination	DELLNLLKTLDEDSK HHHHHHHHHCCCCCC	50.65	29967540
478	Phosphorylation	ELLNLLKTLDEDSKL HHHHHHHHCCCCCCC	39.14	-
486	Phosphorylation	LDEDSKLSAKEKKKL CCCCCCCCHHHHHHH	40.82	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DEPD7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DEPD7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DEPD7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TF2B_HUMAN	GTF2B	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152, AND MASSSPECTROMETRY.
PubMed: 18669648