SESN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SESN1_HUMAN
• UniProt AC: Q9Y6P5
• Protein Name: Sestrin-1 {ECO:0000305}
• Gene Name: SESN1 {ECO:0000312|HGNC:HGNC:21595}
• Organism: Homo sapiens (Human).
• Sequence Length: 492
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. [PubMed: 25263562]
• Protein Sequence: MRLAAAANEAYTAPLAVSGLLGCKQCGGGRDQDEELGIRIPRPLGQGPSRFIPEKEILQVGSEDAQMHALFADSFAALGRLDNITLVMVFHPQYLESFLKTQHYLLQMDGPLPLHYRHYIGIMAAARHQCSYLVNLHVNDFLHVGGDPKWLNGLENAPQKLQNLGELNKVLAHRPWLITKEHIEGLLKAEEHSWSLAELVHAVVLLTHYHSLASFTFGCGISPEIHCDGGHTFRPPSVSNYCICDITNGNHSVDEMPVNSAENVSVSDSFFEVEALMEKMRQLQECRDEEEASQEEMASRFEIEKRESMFVFSSDDEEVTPARAVSRHFEDTSYGYKDFSRHGMHVPTFRVQDYCWEDHGYSLVNRLYPDVGQLIDEKFHIAYNLTYNTMAMHKDVDTSMLRRAIWNYIHCMFGIRYDDYDYGEINQLLDRSFKVYIKTVVCTPEKVTKRMYDSFWRQFKHSEKVHVNLLLIEARMQAELLYALRAITRYMT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
73 (in isoform 2)	Phosphorylation	-	36.63	-
97	Phosphorylation	FHPQYLESFLKTQHY ECHHHHHHHHHHHHH	33.03	24719451
101	Phosphorylation	YLESFLKTQHYLLQM HHHHHHHHHHHHHHC	23.79	24043423
104	Phosphorylation	SFLKTQHYLLQMDGP HHHHHHHHHHHCCCC	10.17	24043423
116	Phosphorylation	DGPLPLHYRHYIGIM CCCCCCCHHHHHHHH	13.53	24043423
119	Phosphorylation	LPLHYRHYIGIMAAA CCCCHHHHHHHHHHH	7.58	-
271 (in isoform 3)	Ubiquitination	-	13.72	21890473
271	Ubiquitination	VSVSDSFFEVEALME EECCCCHHHHHHHHH	13.72	21890473
293	Phosphorylation	CRDEEEASQEEMASR CCCHHHHCHHHHHHH	41.21	17525332
313	Phosphorylation	RESMFVFSSDDEEVT CCCCEEECCCCCCCC	27.79	30576142
314	Phosphorylation	ESMFVFSSDDEEVTP CCCEEECCCCCCCCH	37.30	23898821
320	Phosphorylation	SSDDEEVTPARAVSR CCCCCCCCHHHHHHH	17.95	27251275
326	Phosphorylation	VTPARAVSRHFEDTS CCHHHHHHHHCCCCC	21.03	-
332	Phosphorylation	VSRHFEDTSYGYKDF HHHHCCCCCCCCCCH	19.36	29978859
333	Phosphorylation	SRHFEDTSYGYKDFS HHHCCCCCCCCCCHH	28.96	29978859
334	Phosphorylation	RHFEDTSYGYKDFSR HHCCCCCCCCCCHHH	26.94	29978859
336	Phosphorylation	FEDTSYGYKDFSRHG CCCCCCCCCCHHHCC	10.11	29978859
337	Ubiquitination	EDTSYGYKDFSRHGM CCCCCCCCCHHHCCC	48.19	23000965
337 (in isoform 1)	Ubiquitination	-	48.19	21890473
340	Phosphorylation	SYGYKDFSRHGMHVP CCCCCCHHHCCCCCC	33.24	29978859
396	Ubiquitination	TMAMHKDVDTSMLRR CCCCCCCCCHHHHHH	11.74	21890473
396 (in isoform 2)	Ubiquitination	-	11.74	21890473
398	Phosphorylation	AMHKDVDTSMLRRAI CCCCCCCHHHHHHHH	18.84	29759185
399	Phosphorylation	MHKDVDTSMLRRAIW CCCCCCHHHHHHHHH	16.03	29759185
482	Phosphorylation	RMQAELLYALRAITR HHHHHHHHHHHHHHH	19.06	22210691
488	Phosphorylation	LYALRAITRYMT--- HHHHHHHHHHCC---	18.11	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SESN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SESN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SESN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRDX1_HUMAN	PRDX1	physical	15105503
SQSTM_HUMAN	SQSTM1	physical	23274085
RBX1_HUMAN	RBX1	physical	23274085
KEAP1_HUMAN	KEAP1	physical	23274085

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-314, AND MASSSPECTROMETRY.
PubMed: 19690332

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-293, AND MASSSPECTROMETRY.
PubMed: 17525332