K0825_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K0825_HUMAN
• UniProt AC: Q8IV33
• Protein Name: Uncharacterized protein KIAA0825
• Gene Name: KIAA0825
• Organism: Homo sapiens (Human).
• Sequence Length: 1275
• Protein Sequence: MDWDDEYSHNSFDLHCLLNSFPGDLEFEQIFSDIDEKIEQNAASIKHCIKEIQSEINKQCPGVQLQTTTDCFEWLTNYNYSTSESSFISHGDLIKFFKTLQDLLKNEQNQEEMTLDLLWDLSCHSSVSFPSTLSGTSFHFLSRTSLHSVEDNSSMDVKSMWDDIRLHLRRFLVSKLQSHNEINNSQQKILLKKQCLQQLLFLYPESEVIIKYQNIQNKLLANLLWNCFPSYNRDSNLDVIAHGYQSTMLKLYSVIKEDFNTLCEILAPSSMVKFIKETYLDTVTEEMAKFLENFCELQFRENAVRVVKTSKSSSKHRGAVHALVTTECPQKGRNFSLPLDKVEFLSQLIKSFMKLEKGVQELFDEILLSLKITRDTSGILEKSDREVVMEKPRANETNIPSEQSLPGKEATLLDFGWRSAFKEVSLPMAHCVVTAIEGFSTKILQQEQNERSSAVSYAMNLVNVQQVWQDSHMFPEEEQPKKIGKFCSDIMEKLDTMLPLALACRDDSFQEIRANLVEACCKVATAVLQRLQERAKEVPSKAPLKNLHTYLSTAVYVFQHFKRYDNLMKEMTKKPIFLVLVQRYQEFINTLQFQVTNYCVRVCATSILQDAESHHWDDYKAFYEGERCSFSIQMWHYFCWSLHYDLWTILPPKLAQEILVEVLEKSLSLLASRYARAHPSRKRTPQLRLDVTTILICTENMLWSVCTSVQKLLNPHQHTDDKIFKIHTHCNNLFTTLVILTSPLTELYKTFQHGLDESASDSLKSFFKQPLYWVSCISHFYPSLLRTPSAGGLKAEGQLKLLLSQPRCNWNLLLETLLHHDGLLLRILLKSSKQVSDTENNLNQGPSLMEAIFKILYHCSFSPQTFANVFVSYMEEEQLWDFLYNIPVSTCVEYELEVIRCLRLALTDAIKDTVQQIVSVMSSRRNCETNLNKHIVPDCLLESMPKEWNYSPKETNRKESCKSFTRLTAQAVSIVISKLPTVIACLPPPVKYFFFLSERKMSKKFVELKKAGLLVWNLIVIICRIFEDGNTVELLTGASLDRWSKEKLGLICMCLKSIMGDQTSIHNQMIQKVIQSIEQQKPNWIERQLLKARKLSTECAFMTIEKSTALQEGDVALELTEQKINTMVLDLCHKPGGREYLRQIYHIMQLNEEYLKEQLFSMNSSEEKPLPIRPLKTTLRSIEDQPSAFNPFHVYKAFSENMLDQSAITKWNWNWAKLLPNYLRLDKMTFSVLLKNRWEMKKDETLEEEEKAILEHLKQICTPQNSSASDNIEEQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Ubiquitination	EQNAASIKHCIKEIQ HHHHHHHHHHHHHHH	29.90	29967540
54	Phosphorylation	HCIKEIQSEINKQCP HHHHHHHHHHHHHCC	46.21	22617229
315	Acetylation	KTSKSSSKHRGAVHA ECCCCCCCCCCCEEE	38.99	11697979
326	Phosphorylation	AVHALVTTECPQKGR CEEEEEEECCCCCCC	28.27	-
331	Ubiquitination	VTTECPQKGRNFSLP EEECCCCCCCCCCCC	45.00	29967540
369	Phosphorylation	LFDEILLSLKITRDT HHHHHHHHCCCCCCC	24.95	24719451
425	Phosphorylation	RSAFKEVSLPMAHCV HHHHHHCCCCHHHHH	28.04	29759185
434	Phosphorylation	PMAHCVVTAIEGFST CHHHHHHHHHHHHHH	11.08	29116813
440	Phosphorylation	VTAIEGFSTKILQQE HHHHHHHHHHHHHHH	39.38	29759185
441	Phosphorylation	TAIEGFSTKILQQEQ HHHHHHHHHHHHHHH	21.60	29759185
549	Phosphorylation	APLKNLHTYLSTAVY CCCCHHHHHHHHHHH	29.35	27067055
552	Phosphorylation	KNLHTYLSTAVYVFQ CHHHHHHHHHHHHHH	12.14	27067055
553	Phosphorylation	NLHTYLSTAVYVFQH HHHHHHHHHHHHHHH	19.97	27067055
556	Phosphorylation	TYLSTAVYVFQHFKR HHHHHHHHHHHHHHH	7.96	27067055
666	Phosphorylation	LVEVLEKSLSLLASR HHHHHHHHHHHHHHH	17.51	23312004
668	Phosphorylation	EVLEKSLSLLASRYA HHHHHHHHHHHHHHH	28.55	23312004
672	Phosphorylation	KSLSLLASRYARAHP HHHHHHHHHHHHHCC	26.29	-
680	Phosphorylation	RYARAHPSRKRTPQL HHHHHCCCCCCCCCC	40.33	-
764	Ubiquitination	ESASDSLKSFFKQPL CCCHHHHHHHHCCCH	49.52	29967540
772	Phosphorylation	SFFKQPLYWVSCISH HHHCCCHHHHHHHHH	15.50	24043423
775	Phosphorylation	KQPLYWVSCISHFYP CCCHHHHHHHHHHCH	7.50	24043423
778	Phosphorylation	LYWVSCISHFYPSLL HHHHHHHHHHCHHHH	16.33	24043423
781	Phosphorylation	VSCISHFYPSLLRTP HHHHHHHCHHHHCCC	6.11	24043423
783	Phosphorylation	CISHFYPSLLRTPSA HHHHHCHHHHCCCCC	28.76	24043423
804	Phosphorylation	GQLKLLLSQPRCNWN HHHHHHHCCCCCCHH	37.80	24719451
905 (in isoform 3)	Phosphorylation	-	11.28	-
907	Phosphorylation	RCLRLALTDAIKDTV HHHHHHHHHHHHHHH	20.13	-
913	Phosphorylation	LTDAIKDTVQQIVSV HHHHHHHHHHHHHHH	18.40	27080861
919	Phosphorylation	DTVQQIVSVMSSRRN HHHHHHHHHHHHCCC	17.46	27080861
922	Phosphorylation	QQIVSVMSSRRNCET HHHHHHHHHCCCCCC	20.66	27080861
923	Phosphorylation	QIVSVMSSRRNCETN HHHHHHHHCCCCCCC	19.70	27080861
968	Phosphorylation	CKSFTRLTAQAVSIV HHHHHHHHHHHHHHH	17.27	-
978	Ubiquitination	AVSIVISKLPTVIAC HHHHHHHCCCCCCCC	47.57	-
1031	Phosphorylation	RIFEDGNTVELLTGA HHCCCCCEEEEECCC	22.38	23403867
1036	Phosphorylation	GNTVELLTGASLDRW CCEEEEECCCCHHHC	43.24	23403867
1039	Phosphorylation	VELLTGASLDRWSKE EEEECCCCHHHCCHH	31.95	23403867
1057	Phosphorylation	LICMCLKSIMGDQTS HHHHHHHHHHCCCCH	12.59	-
1063	Phosphorylation	KSIMGDQTSIHNQMI HHHHCCCCHHHHHHH	34.09	25003641
1064	Phosphorylation	SIMGDQTSIHNQMIQ HHHCCCCHHHHHHHH	19.06	-
1081	Ubiquitination	IQSIEQQKPNWIERQ HHHHHHHCCCHHHHH	39.76	29967540
1140	Phosphorylation	HKPGGREYLRQIYHI CCCCHHHHHHHHHHH	13.06	28796482
1145	Phosphorylation	REYLRQIYHIMQLNE HHHHHHHHHHHHHCH	4.13	28796482
1154	Phosphorylation	IMQLNEEYLKEQLFS HHHHCHHHHHHHHHC	19.52	28796482
1161	Phosphorylation	YLKEQLFSMNSSEEK HHHHHHHCCCCCCCC	26.16	-
1199	Phosphorylation	FHVYKAFSENMLDQS HHHHHHHHHCCCCHH	32.68	29978859
1206	Phosphorylation	SENMLDQSAITKWNW HHCCCCHHHHHHCCH	4.45	29978859
1209	Phosphorylation	MLDQSAITKWNWNWA CCCHHHHHHCCHHHH	23.62	29978859
1229	Phosphorylation	YLRLDKMTFSVLLKN HHHCCHHHHHHHHHC	20.64	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K0825_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K0825_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K0825_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.