dbPTM

NFXL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NFXL1_HUMAN
UniProt AC	Q6ZNB6
Protein Name	NF-X1-type zinc finger protein NFXL1
Gene Name	NFXL1
Organism	Homo sapiens (Human).
Sequence Length	911
Subcellular Localization	Membrane Single-pass membrane protein .
Protein Description
Protein Sequence	MEASWRQVAGGRGRSRGRATAAPSGNGVHLRGAGGGREKGSVGAVPSGTSPGGVATTAAAGSRHSPAGSQALQTTAASELMSQKKFEEIKKANQAAARKLVEEQFSSSSEEGDEDFEGKQGKILANTFITYTTQTDGDTRELERTKQYVNEAFQAGAMTCLICIASVKRNQAVWSCSGCFCIFHMPCIQKWAKDSQFLVSSVTDDDFGKKDCPWPCPKCRFEYKRSETPSRYYCYCGKVEDPPLDPWLVPHSCGQVCEREFKPPCGHKCLLLCHPGPCPPCPKMVTTTCYCKKAKPIPRRCSAKEWSCQLPCGQKLLCGQHKCENPCHAGSCQPCPRVSRQKCVCGKKVAERSCASPLWHCDQVCGKTLPCGNHTCEQVCHVGACGECPRSGKRFCPCQKSKFSLPCTEDVPTCGDSCDKVLECGIHRCSQRCHRGPCETCRQEVEKHCRCGKHTKRMPCHKPYLCETKCVKMRDCQKHQCRRKCCPGNCPPCDQNCGRTLGCRNHKCPSVCHRGSCYPCPETVDVKCNCGNTKVTVPCGRERTTRPPKCKEQCSRPPTCHHTSQEKHRCHFGSCPPCHQPCQKVLEKCGHLCPAPCHDQALIKQTGRHQPTGPWEQPSEPAFIQTALPCPPCQVPIPMECLGKHEVSPLPCHAVGPYSCKRVCGRILDCQNHTCMKECHKVTKTDGCTGKNKAGPECLHCEEGCSKSRPLGCLHPCILRCHPGECPPCVQMLRIKCHCKITSLYVECRKITTADVNEKNLLSCCKNQCPKELPCGHRCKEMCHPGECPFNCNQKVKLRCPCKRIKKELQCNKVRENQVSIECDTTCKEMKRKASEIKEAEAKAALEEEKRRQQAELEAFENRLKGRRKKNRKRDEVAVELSLWQKHKYYLISVCGVVVVVFAWYITHDVN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MEASWRQVAGG ----CCCCCHHHCCC	14.97	24719451
18	Methylation	GRGRSRGRATAAPSG CCCCCCCCCCCCCCC	27.88	24384531
39	Ubiquitination	GAGGGREKGSVGAVP CCCCCCCCCCEECCC	55.94	-
41	Phosphorylation	GGGREKGSVGAVPSG CCCCCCCCEECCCCC	28.57	24732914
47	Phosphorylation	GSVGAVPSGTSPGGV CCEECCCCCCCCCCC	48.37	25159151
49	Phosphorylation	VGAVPSGTSPGGVAT EECCCCCCCCCCCCC	35.77	25159151
50	Phosphorylation	GAVPSGTSPGGVATT ECCCCCCCCCCCCCC	25.69	25159151
56	Phosphorylation	TSPGGVATTAAAGSR CCCCCCCCCCCCCCC	17.98	24732914
57	O-linked_Glycosylation	SPGGVATTAAAGSRH CCCCCCCCCCCCCCC	12.45	28657654
57	Phosphorylation	SPGGVATTAAAGSRH CCCCCCCCCCCCCCC	12.45	24732914
62	Phosphorylation	ATTAAAGSRHSPAGS CCCCCCCCCCCCCHH	23.30	24732914
65	Phosphorylation	AAAGSRHSPAGSQAL CCCCCCCCCCHHHHH	18.48	30266825
69	Phosphorylation	SRHSPAGSQALQTTA CCCCCCHHHHHHHHH	17.87	30266825
74	Phosphorylation	AGSQALQTTAASELM CHHHHHHHHHHHHHH	21.18	23663014
75	Phosphorylation	GSQALQTTAASELMS HHHHHHHHHHHHHHC	13.78	23663014
78	Phosphorylation	ALQTTAASELMSQKK HHHHHHHHHHHCHHH	28.88	24732914
82	Phosphorylation	TAASELMSQKKFEEI HHHHHHHCHHHHHHH	52.01	24732914
84	Acetylation	ASELMSQKKFEEIKK HHHHHCHHHHHHHHH	52.72	26051181
84	Ubiquitination	ASELMSQKKFEEIKK HHHHHCHHHHHHHHH	52.72	-
90	Ubiquitination	QKKFEEIKKANQAAA HHHHHHHHHHHHHHH	49.46	-
106	Phosphorylation	KLVEEQFSSSSEEGD HHHHHHHHCCCCCCC	29.07	28102081
107	Phosphorylation	LVEEQFSSSSEEGDE HHHHHHHCCCCCCCC	38.89	22617229
108	Phosphorylation	VEEQFSSSSEEGDED HHHHHHCCCCCCCCC	40.34	22617229
109	Phosphorylation	EEQFSSSSEEGDEDF HHHHHCCCCCCCCCC	41.43	28102081
122	Ubiquitination	DFEGKQGKILANTFI CCCCCCCEEEEEEEE	31.86	-
193	Ubiquitination	PCIQKWAKDSQFLVS HHHHHHHCCCCEEEE	57.72	-
203	Phosphorylation	QFLVSSVTDDDFGKK CEEEEECCCCCCCCC	35.34	-
209	Acetylation	VTDDDFGKKDCPWPC CCCCCCCCCCCCCCC	45.49	26051181
209	Ubiquitination	VTDDDFGKKDCPWPC CCCCCCCCCCCCCCC	45.49	-
209 (in isoform 2)	Ubiquitination	-	45.49	-
210	Ubiquitination	TDDDFGKKDCPWPCP CCCCCCCCCCCCCCC	66.01	-
265	S-palmitoylation	EREFKPPCGHKCLLL CCCCCCCCCCEEEEE	13.96	21044946
292	Ubiquitination	VTTTCYCKKAKPIPR EEEEEEECCCCCCCC	29.32	-
293	Ubiquitination	TTTCYCKKAKPIPRR EEEEEECCCCCCCCC	59.07	-
315	Ubiquitination	CQLPCGQKLLCGQHK CCCCCCCEEECCCCC	28.80	-
322	Acetylation	KLLCGQHKCENPCHA EEECCCCCCCCCCCC	35.04	26051181
322	Ubiquitination	KLLCGQHKCENPCHA EEECCCCCCCCCCCC	35.04	-
331	Phosphorylation	ENPCHAGSCQPCPRV CCCCCCCCCCCCCCC	15.46	23927012
339	Phosphorylation	CQPCPRVSRQKCVCG CCCCCCCCCCCCCCC	30.21	29888752
353	Phosphorylation	GKKVAERSCASPLWH CHHHHHHHCCCCCCC	12.92	29449344
354	S-palmitoylation	KKVAERSCASPLWHC HHHHHHHCCCCCCCH	5.64	21044946
356	Phosphorylation	VAERSCASPLWHCDQ HHHHHCCCCCCCHHH	25.50	28985074
361	S-palmitoylation	CASPLWHCDQVCGKT CCCCCCCHHHHCCCC	2.37	21044946
365	S-palmitoylation	LWHCDQVCGKTLPCG CCCHHHHCCCCCCCC	3.72	21044946
371	S-palmitoylation	VCGKTLPCGNHTCEQ HCCCCCCCCCCCCCC	10.82	21044946
376	S-palmitoylation	LPCGNHTCEQVCHVG CCCCCCCCCCEEECC	2.40	21044946
380	S-palmitoylation	NHTCEQVCHVGACGE CCCCCCEEECCCCCC	1.84	21044946
385	S-palmitoylation	QVCHVGACGECPRSG CEEECCCCCCCCCCC	3.76	21044946
388	S-palmitoylation	HVGACGECPRSGKRF ECCCCCCCCCCCCCC	1.74	21044946
396	S-palmitoylation	PRSGKRFCPCQKSKF CCCCCCCCCCCCCCC	3.70	21044946
398	S-palmitoylation	SGKRFCPCQKSKFSL CCCCCCCCCCCCCCC	9.29	21044946
400	Ubiquitination	KRFCPCQKSKFSLPC CCCCCCCCCCCCCCC	63.43	-
402	Acetylation	FCPCQKSKFSLPCTE CCCCCCCCCCCCCCC	46.11	26051181
402	Ubiquitination	FCPCQKSKFSLPCTE CCCCCCCCCCCCCCC	46.11	-
404	Phosphorylation	PCQKSKFSLPCTEDV CCCCCCCCCCCCCCC	34.83	28555341
420	Ubiquitination	TCGDSCDKVLECGIH CCCHHHHHHHHHHHH	53.71	-
462	Ubiquitination	TKRMPCHKPYLCETK CCCCCCCCCEEEECC	41.91	-
464	Phosphorylation	RMPCHKPYLCETKCV CCCCCCCEEEECCCE	28.87	-
468	Phosphorylation	HKPYLCETKCVKMRD CCCEEEECCCEEHHH	28.84	21949786
469	Ubiquitination	KPYLCETKCVKMRDC CCEEEECCCEEHHHH	18.10	-
472	Ubiquitination	LCETKCVKMRDCQKH EEECCCEEHHHHCHH	37.37	-
484	Ubiquitination	QKHQCRRKCCPGNCP CHHHHHCCCCCCCCC	22.34	-
484 (in isoform 2)	Ubiquitination	-	22.34	-
507	Ubiquitination	TLGCRNHKCPSVCHR CCCCCCCCCCCCCCC	51.93	-
516	Phosphorylation	PSVCHRGSCYPCPET CCCCCCCCCCCCCCC	15.50	28152594
518	Phosphorylation	VCHRGSCYPCPETVD CCCCCCCCCCCCCEE	15.01	28152594
527	Ubiquitination	CPETVDVKCNCGNTK CCCCEEEEECCCCCE	18.44	-
528	S-palmitoylation	PETVDVKCNCGNTKV CCCEEEEECCCCCEE	5.24	21044946
530	S-palmitoylation	TVDVKCNCGNTKVTV CEEEEECCCCCEEEE	6.61	21044946
534	Ubiquitination	KCNCGNTKVTVPCGR EECCCCCEEEEECCC	39.65	-
563	Phosphorylation	RPPTCHHTSQEKHRC CCCCCCCCCCCCCCC	14.40	23879269
564	Phosphorylation	PPTCHHTSQEKHRCH CCCCCCCCCCCCCCC	31.80	23879269
567	Ubiquitination	CHHTSQEKHRCHFGS CCCCCCCCCCCCCCC	28.81	-
584	Ubiquitination	PCHQPCQKVLEKCGH CCCHHHHHHHHHHCC	56.35	-
588	Ubiquitination	PCQKVLEKCGHLCPA HHHHHHHHHCCCCCC	41.16	-
589	S-palmitoylation	CQKVLEKCGHLCPAP HHHHHHHHCCCCCCC	2.79	21044946
593	S-palmitoylation	LEKCGHLCPAPCHDQ HHHHCCCCCCCCCCH	1.93	21044946
597	S-palmitoylation	GHLCPAPCHDQALIK CCCCCCCCCCHHHHH	6.32	21044946
604	Ubiquitination	CHDQALIKQTGRHQP CCCHHHHHHCCCCCC	42.53	-
644	Ubiquitination	IPMECLGKHEVSPLP CCHHHCCCCCCCCCC	24.52	-
648	Phosphorylation	CLGKHEVSPLPCHAV HCCCCCCCCCCCCCC	20.10	25159151
659	Phosphorylation	CHAVGPYSCKRVCGR CCCCCCCCHHHHHHH	19.12	25159151
661	Ubiquitination	AVGPYSCKRVCGRIL CCCCCCHHHHHHHHH	41.76	-
677	Ubiquitination	CQNHTCMKECHKVTK CCCCCCHHHHCEECC	60.37	-
681	Ubiquitination	TCMKECHKVTKTDGC CCHHHHCEECCCCCC	64.36	-
684	Ubiquitination	KECHKVTKTDGCTGK HHHCEECCCCCCCCC	47.83	-
691	Ubiquitination	KTDGCTGKNKAGPEC CCCCCCCCCCCCCCC	36.80	-
693	Ubiquitination	DGCTGKNKAGPECLH CCCCCCCCCCCCCCC	59.20	-
698	S-palmitoylation	KNKAGPECLHCEEGC CCCCCCCCCCCCCCC	3.37	21044946
701	S-palmitoylation	AGPECLHCEEGCSKS CCCCCCCCCCCCCCC	3.08	21044946
705	S-palmitoylation	CLHCEEGCSKSRPLG CCCCCCCCCCCCCCC	5.39	21044946
708	Phosphorylation	CEEGCSKSRPLGCLH CCCCCCCCCCCCCCC	23.88	23898821
740	Ubiquitination	LRIKCHCKITSLYVE HEEEEEEEEEEEEEE	25.92	-
742	Phosphorylation	IKCHCKITSLYVECR EEEEEEEEEEEEEEE	9.73	23312004
743	Phosphorylation	KCHCKITSLYVECRK EEEEEEEEEEEEEEE	22.60	23312004
745	Phosphorylation	HCKITSLYVECRKIT EEEEEEEEEEEEECC	8.25	-
750	Ubiquitination	SLYVECRKITTADVN EEEEEEEECCCCCCC	56.94	-
759	Ubiquitination	TTADVNEKNLLSCCK CCCCCCHHHHHHHHH	47.92	-
766	Ubiquitination	KNLLSCCKNQCPKEL HHHHHHHHCCCCCCC	55.14	-
771	Ubiquitination	CCKNQCPKELPCGHR HHHCCCCCCCCCCCC	78.49	-
780	Ubiquitination	LPCGHRCKEMCHPGE CCCCCCHHHCCCCCC	48.73	-
795	Ubiquitination	CPFNCNQKVKLRCPC CCCCCCCCCEEECCC	27.61	-
807	Ubiquitination	CPCKRIKKELQCNKV CCCHHHHHHHCCCCC	62.37	-
813	Ubiquitination	KKELQCNKVRENQVS HHHHCCCCCCCCCCC	50.74	-
820	Phosphorylation	KVRENQVSIECDTTC CCCCCCCCEEECCHH	11.69	28857561
825	Phosphorylation	QVSIECDTTCKEMKR CCCEEECCHHHHHHH	45.83	25627689
835	Phosphorylation	KEMKRKASEIKEAEA HHHHHHHHHHHHHHH	42.78	23927012
838	Ubiquitination	KRKASEIKEAEAKAA HHHHHHHHHHHHHHH	46.98	-
843	Ubiquitination	EIKEAEAKAALEEEK HHHHHHHHHHHHHHH	26.20	-
850	Ubiquitination	KAALEEEKRRQQAEL HHHHHHHHHHHHHHH	57.04	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NFXL1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NFXL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NFXL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of NFXL1_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NFXL1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50; SER-65; SER-106;SER-107; SER-108 AND SER-109, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106; SER-107; SER-108AND SER-109, AND MASS SPECTROMETRY.	17081983 [Abstract]