OCAD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OCAD2_HUMAN
• UniProt AC: Q56VL3
• Protein Name: OCIA domain-containing protein 2
• Gene Name: OCIAD2
• Organism: Homo sapiens (Human).
• Sequence Length: 154
• Subcellular Localization: Endosome .
• Protein Sequence: MASASARGNQDKDAHFPPPSKQSLLFCPKSKLHIHRAEISKIMRECQEESFWKRALPFSLVSMLVTQGLVYQGYLAANSRFGSLPKVALAGLLGFGLGKVSYIGVCQSKFHFFEDQLRGAGFGPQHNRHCLLTCEECKIKHGLSEKGDSQPSAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MASASARGNQDK ---CCCCCCCCCCCC	18.92	29514088
21	Ubiquitination	AHFPPPSKQSLLFCP CCCCCCCCCCEEECC	50.08	29967540
31	2-Hydroxyisobutyrylation	LLFCPKSKLHIHRAE EEECCCCCCEEEHHH	50.65	-
31	Acetylation	LLFCPKSKLHIHRAE EEECCCCCCEEEHHH	50.65	25825284
41	Acetylation	IHRAEISKIMRECQE EEHHHHHHHHHHHHH	46.30	19608861
41	2-Hydroxyisobutyrylation	IHRAEISKIMRECQE EEHHHHHHHHHHHHH	46.30	-
41	Ubiquitination	IHRAEISKIMRECQE EEHHHHHHHHHHHHH	46.30	23000965
53	Acetylation	CQEESFWKRALPFSL HHHHCHHHHHCCHHH	26.28	25825284
53	Ubiquitination	CQEESFWKRALPFSL HHHHCHHHHHCCHHH	26.28	-
53	2-Hydroxyisobutyrylation	CQEESFWKRALPFSL HHHHCHHHHHCCHHH	26.28	-
59	Phosphorylation	WKRALPFSLVSMLVT HHHHCCHHHHHHHHH	26.39	25072903
62	Phosphorylation	ALPFSLVSMLVTQGL HCCHHHHHHHHHCCH	16.22	25072903
66	Phosphorylation	SLVSMLVTQGLVYQG HHHHHHHHCCHHHCH	16.98	25072903
71	Phosphorylation	LVTQGLVYQGYLAAN HHHCCHHHCHHHHHH	10.98	25072903
74	Phosphorylation	QGLVYQGYLAANSRF CCHHHCHHHHHHCCC	4.25	25072903
79	Phosphorylation	QGYLAANSRFGSLPK CHHHHHHCCCCCCCH	25.02	25072903
109	Acetylation	YIGVCQSKFHFFEDQ EEEEECCEEEEHHHH	19.58	25825284
138	Acetylation	LLTCEECKIKHGLSE EEECCHHHHHCCCCC	59.05	25953088
138	Ubiquitination	LLTCEECKIKHGLSE EEECCHHHHHCCCCC	59.05	-
140	Ubiquitination	TCEECKIKHGLSEKG ECCHHHHHCCCCCCC	19.67	-
144	Phosphorylation	CKIKHGLSEKGDSQP HHHHCCCCCCCCCCC	41.68	30108239
146	Ubiquitination	IKHGLSEKGDSQPSA HHCCCCCCCCCCCCC	65.72	-
146	2-Hydroxyisobutyrylation	IKHGLSEKGDSQPSA HHCCCCCCCCCCCCC	65.72	-
149	Phosphorylation	GLSEKGDSQPSAS-- CCCCCCCCCCCCC--	53.30	30108239
152	Phosphorylation	EKGDSQPSAS----- CCCCCCCCCC-----	33.24	25849741
154	Phosphorylation	GDSQPSAS------- CCCCCCCC-------	45.12	26852163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OCAD2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OCAD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OCAD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-41, AND MASS SPECTROMETRY.
PubMed: 19608861