| UniProt ID | UN45B_HUMAN | |
|---|---|---|
| UniProt AC | Q8IWX7 | |
| Protein Name | Protein unc-45 homolog B | |
| Gene Name | UNC45B | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 931 | |
| Subcellular Localization | Cytoplasm, cytosol. | |
| Protein Description | Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. Is necessary for normal early lens development.. | |
| Protein Sequence | MAEVEAVQLKEEGNRHFQLQDYKAATNSYSQALKLTKDKALLATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQALEHLGKLDQAFKDVQRCATLEPRNQNFQEMLRRLNTSIQEKLRVQFSTDSRVQKMFEILLDENSEADKREKAANNLIVLGREEAGAEKIFQNNGVALLLQLLDTKKPELVLAAVRTLSGMCSGHQARATVILHAVRIDRICSLMAVENEEMSLAVCNLLQAIIDSLSGEDKREHRGKEEALVLDTKKDLKQITSHLLDMLVSKKVSGQGRDQALNLLNKNVPRKDLAIHDNSRTIYVVDNGLRKILKVVGQVPDLPSCLPLTDNTRMLASILINKLYDDLRCDPERDHFRKICEEYITGKFDPQDMDKNLNAIQTVSGILQGPFDLGNQLLGLKGVMEMMVALCGSERETDQLVAVEALIHASTKLSRATFIITNGVSLLKQIYKTTKNEKIKIRTLVGLCKLGSAGGTDYGLRQFAEGSTEKLAKQCRKWLCNMSIDTRTRRWAVEGLAYLTLDADVKDDFVQDVPALQAMFELAKAGTSDKTILYSVATTLVNCTNSYDVKEVIPELVQLAKFSKQHVPEEHPKDKKDFIDMRVKRLLKAGVISALACMVKADSAILTDQTKELLARVFLALCDNPKDRGTIVAQGGGKALIPLALEGTDVGKVKAAHALAKIAAVSNPDIAFPGERVYEVVRPLVRLLDTQRDGLQNYEALLGLTNLSGRSDKLRQKIFKERALPDIENYMFENHDQLRQAATECMCNMVLHKEVQERFLADGNDRLKLVVLLCGEDDDKVQNAAAGALAMLTAAHKKLCLKMTQVTTQWLEILQRLCLHDQLSVQHRGLVIAYNLLAADAELAKKLVESELLEILTVVGKQEPDEKKAEVVQTARECLIKCMDYGFIKPVS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 44 | Phosphorylation | KDKALLATLYRNRAA CCHHHHHHHHHCHHC | 25.04 | - | |
| 46 | Phosphorylation | KALLATLYRNRAACG HHHHHHHHHCHHCCC | 11.07 | - | |
| 74 | Phosphorylation | SRAIDINSSDIKALY HHHHCCCHHHHHHHH | 29.71 | - | |
| 75 | Phosphorylation | RAIDINSSDIKALYR HHHCCCHHHHHHHHH | 38.58 | - | |
| 81 | Phosphorylation | SSDIKALYRRCQALE HHHHHHHHHHHHHHH | 10.81 | - | |
| 133 | Phosphorylation | EKLRVQFSTDSRVQK HHHHHCCCCCHHHHH | 17.76 | 26437602 | |
| 134 | Phosphorylation | KLRVQFSTDSRVQKM HHHHCCCCCHHHHHH | 39.00 | - | |
| 136 | Phosphorylation | RVQFSTDSRVQKMFE HHCCCCCHHHHHHHH | 34.14 | - | |
| 150 | Phosphorylation | EILLDENSEADKREK HHHHCCCCHHHHHHH | 31.92 | 28450419 | |
| 279 | Phosphorylation | KKDLKQITSHLLDML HHHHHHHHHHHHHHH | 13.96 | 28555341 | |
| 289 | Acetylation | LLDMLVSKKVSGQGR HHHHHHHCCCCCCCH | 50.11 | 30593255 | |
| 318 | Phosphorylation | DLAIHDNSRTIYVVD HEEEECCCCEEEEEC | 36.54 | 20873877 | |
| 453 | Phosphorylation | IHASTKLSRATFIIT HHHCCCHHCCEEEEE | 22.79 | 22210691 | |
| 464 | Phosphorylation | FIITNGVSLLKQIYK EEEECHHHHHHHHHH | 29.40 | 24719451 | |
| 471 | Acetylation | SLLKQIYKTTKNEKI HHHHHHHHHCCCCCC | 51.88 | 30593261 | |
| 491 | Phosphorylation | VGLCKLGSAGGTDYG HHHHHHCCCCCCHHH | 33.89 | 24505115 | |
| 495 | Phosphorylation | KLGSAGGTDYGLRQF HHCCCCCCHHHHHHH | 25.73 | - | |
| 567 | Phosphorylation | ELAKAGTSDKTILYS HHHHCCCCCCHHHHH | 35.87 | 17081983 | |
| 602 | Phosphorylation | LVQLAKFSKQHVPEE HHHHHHHHHCCCCCC | 30.60 | 27251275 | |
| 669 | Phosphorylation | DNPKDRGTIVAQGGG CCCCCCCCEEEECCC | 17.11 | 22496350 | |
| 717 | Phosphorylation | AFPGERVYEVVRPLV CCCCHHHHHHHHHHH | 14.82 | - | |
| 906 | Acetylation | GKQEPDEKKAEVVQT CCCCCCHHHHHHHHH | 65.74 | 18530591 | |
| 907 | Acetylation | KQEPDEKKAEVVQTA CCCCCHHHHHHHHHH | 47.97 | 18530599 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UN45B_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UN45B_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| HS90B_HUMAN | HSP90AB1 | physical | 25036637 | |
| HS90A_HUMAN | HSP90AA1 | physical | 25036637 | |
| AHSA1_HUMAN | AHSA1 | physical | 25036637 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 616279 | Cataract 43 (CTRCT43) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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