| UniProt ID | RN207_HUMAN | |
|---|---|---|
| UniProt AC | Q6ZRF8 | |
| Protein Name | RING finger protein 207 | |
| Gene Name | RNF207 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 634 | |
| Subcellular Localization | Cytoplasm . Probably located in the endoplasmic reticulum and/or possibly the cis-Golgi apparatus. | |
| Protein Description | Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner.. | |
| Protein Sequence | MSGAIFGPLEGPSSLDAPSIHPLVCPLCHVQYERPCLLDCFHDFCAGCLRGRATDGRLTCPLCQHQTVLKGPSGLPPVDRLLQFLVDSSGDGVEAVRCANCDLECSEQDVETTYFCNTCGQPLCARCRDETHRARMFARHDIVALGQRSRDVPQKCTLHAEPYLLFSTDKKLLLCIRCFRDMQKESRAHCVDLESAYVQGCERLEQAVLAVKALQTATREAIALLQAMVEEVRHSAAEEEDAIHALFGSMQDRLAERKALLLQAVQSQYEEKDKAFKEQLSHLATLLPTLQVHLVICSSFLSLANKAEFLDLGYELMERLQGIVTRPHHLRPIQSSKIASDHRAEFARCLEPLLLLGPRRVAAAASGANTLAGGLGPKALTGPHCPSPVGKMSGSPVQKPTLHRSISTKVLLAEGENTPFAEHCRHYEDSYRHLQAEMQSLKDQVQELHRDLTKHHSLIKAEIMGDVLHKSLQLDVQIASEHASLEGMRVVFQEIWEEAYQRVANEQEIYEAQLHDLLQLRQENAYLTTITKQITPYVRSIAKVKERLEPRFQAPVDEQSESLQNTHDDSRNNAASARNNPGSVPEKREKTSEPKGNSWAPNGLSEEPLLKNMDHHRSKQKNGGDVPTWREHPT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 131 | Phosphorylation | CARCRDETHRARMFA HHHHCCHHHHHHHHH | 22.43 | - | |
| 289 | Phosphorylation | HLATLLPTLQVHLVI HHHHHHHHHHHHHHH | 29.77 | 22817900 | |
| 302 | Phosphorylation | VICSSFLSLANKAEF HHHHHHHHHHCHHHH | 24.35 | 24173317 | |
| 325 | Phosphorylation | ERLQGIVTRPHHLRP HHHHCCCCCCCCCCC | 36.24 | - | |
| 370 | Phosphorylation | AAASGANTLAGGLGP HHHCCCCCCCCCCCC | 19.90 | 22210691 | |
| 387 | Phosphorylation | LTGPHCPSPVGKMSG CCCCCCCCCCCCCCC | 37.30 | 22210691 | |
| 430 | Phosphorylation | HCRHYEDSYRHLQAE HHHHHHHHHHHHHHH | 16.48 | 27251275 | |
| 457 | Phosphorylation | RDLTKHHSLIKAEIM HHHHHHHHHHHHHHH | 31.35 | 24719451 | |
| 560 | Phosphorylation | QAPVDEQSESLQNTH CCCCCHHHHHHHHCC | 27.40 | 25850435 | |
| 562 | Phosphorylation | PVDEQSESLQNTHDD CCCHHHHHHHHCCCC | 40.27 | 25850435 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RN207_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RN207_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RN207_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| KCNH2_HUMAN | KCNH2 | physical | 25281747 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-289, AND MASSSPECTROMETRY. | |
