dbPTM

GCST_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GCST_HUMAN
UniProt AC	P48728
Protein Name	Aminomethyltransferase, mitochondrial {ECO:0000305}
Gene Name	AMT {ECO:0000312\|HGNC:HGNC:473}
Organism	Homo sapiens (Human).
Sequence Length	403
Subcellular Localization	Mitochondrion .
Protein Description	The glycine cleavage system catalyzes the degradation of glycine..
Protein Sequence	MQRAVSVVARLGFRLQAFPPALCRPLSCAQEVLRRTPLYDFHLAHGGKMVAFAGWSLPVQYRDSHTDSHLHTRQHCSLFDVSHMLQTKILGSDRVKLMESLVVGDIAELRPNQGTLSLFTNEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDKVRELQNQGRDVGLEVLDNALLALQGPTAAQVLQAGVADDLRKLPFMTSAVMEVFGVSGCRVTRCGYTGEDGVEISVPVAGAVHLATAILKNPEVKLAGLAARDSLRLEAGLCLYGNDIDEHTTPVEGSLSWTLGKRRRAAMDFPGAKVIVPQLKGRVQRRRVGLMCEGAPMRAHSPILNMEGTKIGTVTSGCPSPSLKKNVAMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKMPFVPTNYYTLK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MQRAVSVVARLGF --CCHHHHHHHHHCC	15.19	24719451
100	Phosphorylation	DRVKLMESLVVGDIA HHHHHHHHEEECCHH	16.70	-
206	Phosphorylation	LRKLPFMTSAVMEVF HHCCCCCHHHHHHHH	17.57	50565033
334	Phosphorylation	GAPMRAHSPILNMEG CCCCCCCCCCCCCCC	16.79	54886899
346	Phosphorylation	MEGTKIGTVTSGCPS CCCCEEEEEECCCCC	24.88	21406692
348	Phosphorylation	GTKIGTVTSGCPSPS CCEEEEEECCCCCHH	21.17	21406692
349	Phosphorylation	TKIGTVTSGCPSPSL CEEEEEECCCCCHHH	33.78	21406692
353	Phosphorylation	TVTSGCPSPSLKKNV EEECCCCCHHHCCCE	31.06	21406692
355	Phosphorylation	TSGCPSPSLKKNVAM ECCCCCHHHCCCEEC	58.10	21406692
357	Acetylation	GCPSPSLKKNVAMGY CCCCHHHCCCEECEE	46.79	7672243

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GCST_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GCST_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GCST_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of GCST_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GCST_HUMAN

Related Literatures of Post-Translational Modification