ESR2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ESR2_RAT
• UniProt AC: Q62986
• Protein Name: Estrogen receptor beta
• Gene Name: Esr2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 530
• Subcellular Localization: Nucleus.
• Protein Description: Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform 3 and isoform 4 are unable to bind DNA and activate transcription due to the truncation of the DNA binding domain. Isoform 2 shows loss of ligand binding affinity and suppresses ER-alpha and ER-beta1 mediated transcriptional activation and may act as a dominant negative regulator of estrogen action..
• Protein Sequence: MEIKNSPSSLSSPASYNCSQSILPLEHGPIYIPSSYVDNRHEYSAMTFYSPAVMNYSVPGSTSNLDGGPVRLSTSPNVLWPTSGHLSPLATHCQSSLLYAEPQKSPWCEARSLEHTLPVNRETLKRKLSGSSCASPVTSPNAKRDAHFCPVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRIVRRQRSSSEQVHCLSKAKRNGGHAPRVKELLLSTLSPEQLVLTLLEAEPPNVLVSRPSMPFTEASMMMSLTKLADKELVHMIGWAKKIPGFVELSLLDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLASANQEAESSRKLTHLLNAVTDALVWVIAKSGISSQQQSVRLANLLMLLSHVRHISNKGMEHLLSMKCKNVVPVYDLLLEMLNAHTLRGYKSSISGSECSSTEDSKNKESSQNLQSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	Phosphorylation	MNYSVPGSTSNLDGG EECCCCCCCCCCCCC	23.69	-
61	O-linked_Glycosylation	MNYSVPGSTSNLDGG EECCCCCCCCCCCCC	23.69	-
87	Phosphorylation	WPTSGHLSPLATHCQ CCCCCCCCCHHHHHH	16.52	-
105	Phosphorylation	LYAEPQKSPWCEARS HHCCCCCCCCHHCCC	20.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
87	S	Phosphorylation	Kinase	MAPK	-	Uniprot
105	S	Phosphorylation	Kinase	MAPK	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
87	S	Phosphorylation	Phosphorylation at Ser-87 and Ser-105 recruits NCOA1.	-
105	S	Phosphorylation	Phosphorylation at Ser-87 and Ser-105 recruits NCOA1.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ESR2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC_RAT	Ubc	physical	21808025
PCNA_RAT	Pcna	physical	19683557
DAAF4_RAT	Dyx1c1	physical	19423554

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.