ZN268_HUMAN - dbPTM
ZN268_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZN268_HUMAN
UniProt AC Q14587
Protein Name Zinc finger protein 268
Gene Name ZNF268
Organism Homo sapiens (Human).
Sequence Length 947
Subcellular Localization Isoform 1: Nucleus .
Isoform 2: Nucleus . Cytoplasm .
Protein Description Isoform 1: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression.; Isoform 2: Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex..
Protein Sequence MATRVRTASIWVPPLQERNSSWDRIRKLQGQESILGQGTPGLQPLPGTPRQKQKSRRIEKVLEWLFISQEQPKITKSWGPLSFMDVFVDFTWEEWQLLDPAQKCLYRSVMLENYSNLVSLGYQHTKPDIIFKLEQGEELCMVQAQVPNQTCPNTVWKIDDLMDWHQENKDKLGSTAKSFECTTFGKLCLLSTKYLSRQKPHKCGTHGKSLKYIDFTSDYARNNPNGFQVHGKSFFHSKHEQTVIGIKYCESIESGKTVNKKSQLMCQQMYMGEKPFGCSCCEKAFSSKSYLLVHQQTHAEEKPYGCNECGKDFSSKSYLIVHQRIHTGEKLHECSECRKTFSFHSQLVIHQRIHTGENPYECCECGKVFSRKDQLVSHQKTHSGQKPYVCNECGKAFGLKSQLIIHERIHTGEKPYECNECQKAFNTKSNLMVHQRTHTGEKPYVCSDCGKAFTFKSQLIVHQGIHTGVKPYGCIQCGKGFSLKSQLIVHQRSHTGMKPYVCNECGKAFRSKSYLIIHTRTHTGEKLHECNNCGKAFSFKSQLIIHQRIHTGENPYECHECGKAFSRKYQLISHQRTHAGEKPYECTDCGKAFGLKSQLIIHQRTHTGEKPFECSECQKAFNTKSNLIVHQRTHTGEKPYSCNECGKAFTFKSQLIVHKGVHTGVKPYGCSQCAKTFSLKSQLIVHQRSHTGVKPYGCSECGKAFRSKSYLIIHMRTHTGEKPHECRECGKSFSFNSQLIVHQRIHTGENPYECSECGKAFNRKDQLISHQRTHAGEKPYGCSECGKAFSSKSYLIIHMRTHSGEKPYECNECGKAFIWKSLLIVHERTHAGVNPYKCSQCEKSFSGKLRLLVHQRMHTREKPYECSECGKAFIRNSQLIVHQRTHSGEKPYGCNECGKTFSQKSILSAHQRTHTGEKPCKCTECGKAFCWKSQLIMHQRTHVDDKH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationATRVRTASIWVPPLQ
CCEEEEEEEECCCHH		19.1728555341
33PhosphorylationRKLQGQESILGQGTP
HHHCCCCCCCCCCCC		18.4127732954
39PhosphorylationESILGQGTPGLQPLP
CCCCCCCCCCCCCCC		13.2928555341
48PhosphorylationGLQPLPGTPRQKQKS
CCCCCCCCCCHHHHH		17.2325850435
106PhosphorylationDPAQKCLYRSVMLEN
CHHHHHHHHHHHHHC		15.43-
114PhosphorylationRSVMLENYSNLVSLG
HHHHHHCHHHHHHCC		6.9122817900
115PhosphorylationSVMLENYSNLVSLGY
HHHHHCHHHHHHCCC		34.9622817900
174PhosphorylationENKDKLGSTAKSFEC
HCHHHCCCCCCCEEE		35.3126657352
175PhosphorylationNKDKLGSTAKSFECT
CHHHCCCCCCCEEEC		35.9826657352
178PhosphorylationKLGSTAKSFECTTFG
HCCCCCCCEEECHHH		24.6626657352
190PhosphorylationTFGKLCLLSTKYLSR
HHHHHHHHCHHHHHC		6.2827251275
191PhosphorylationFGKLCLLSTKYLSRQ
HHHHHHHCHHHHHCC		15.2024719451
251PhosphorylationIGIKYCESIESGKTV
EEEEEEEECCCCCCC		28.2629083192
254PhosphorylationKYCESIESGKTVNKK
EEEEECCCCCCCCHH		43.8729083192
257PhosphorylationESIESGKTVNKKSQL
EECCCCCCCCHHHHH		32.6029083192
262PhosphorylationGKTVNKKSQLMCQQM
CCCCCHHHHHHHHHH		30.1023401153
270PhosphorylationQLMCQQMYMGEKPFG
HHHHHHHHCCCCCCC		9.5324043423
335PhosphorylationGEKLHECSECRKTFS
CCCCEECCHHCCEEE		36.4227251275
340PhosphorylationECSECRKTFSFHSQL
ECCHHCCEEEEECEE		12.7427251275
342PhosphorylationSECRKTFSFHSQLVI
CHHCCEEEEECEEEE		27.5527251275
345PhosphorylationRKTFSFHSQLVIHQR
CCEEEEECEEEEEEE		24.1727251275
377PhosphorylationSRKDQLVSHQKTHSG
ECHHHHHCCCCCCCC		28.8829083192
411PhosphorylationIIHERIHTGEKPYEC
EEEEEECCCCCCCCC		44.6728655764
437PhosphorylationNLMVHQRTHTGEKPY
CEEEEECCCCCCCCE		19.74-
439PhosphorylationMVHQRTHTGEKPYVC
EEEECCCCCCCCEEE		46.56-
521PhosphorylationYLIIHTRTHTGEKLH
EEEEEECCCCCCCCE		25.58-
523PhosphorylationIIHTRTHTGEKLHEC
EEEECCCCCCCCEEC		46.56-
538PhosphorylationNNCGKAFSFKSQLII
CCCCCCEEEECEEEE		36.3024719451
540SumoylationCGKAFSFKSQLIIHQ
CCCCEEEECEEEEEE		35.77-
540SumoylationCGKAFSFKSQLIIHQ
CCCCEEEECEEEEEE		35.77-
584PhosphorylationTHAGEKPYECTDCGK
CCCCCCCEEECCHHH		34.40-
596SumoylationCGKAFGLKSQLIIHQ
HHHHHCCCCEEEEEE		36.21-
596SumoylationCGKAFGLKSQLIIHQ
HHHHHCCCCEEEEEE		36.21-
605PhosphorylationQLIIHQRTHTGEKPF
EEEEEECCCCCCCCC		19.74-
607PhosphorylationIIHQRTHTGEKPFEC
EEEECCCCCCCCCCC		46.56-
610AcetylationQRTHTGEKPFECSEC
ECCCCCCCCCCCHHH		57.2511566381
633PhosphorylationNLIVHQRTHTGEKPY
CEEEEECCCCCCCCC		19.74-
635PhosphorylationIVHQRTHTGEKPYSC
EEEECCCCCCCCCCC		46.56-
717PhosphorylationYLIIHMRTHTGEKPH
EEEEEEEECCCCCCC		19.06-
719PhosphorylationIIHMRTHTGEKPHEC
EEEEEECCCCCCCCC		46.56-
747PhosphorylationIVHQRIHTGENPYEC
EEEEEEECCCCCCCH		43.7628152594
752PhosphorylationIHTGENPYECSECGK
EECCCCCCCHHHHHH		40.9425839225
755PhosphorylationGENPYECSECGKAFN
CCCCCCHHHHHHHCC		24.7928152594
759SumoylationYECSECGKAFNRKDQ
CCHHHHHHHCCCHHH		62.56-
759SumoylationYECSECGKAFNRKDQ
CCHHHHHHHCCCHHH		62.56-
806UbiquitinationMRTHSGEKPYECNEC
EEECCCCCCEECCCC		57.32-
846PhosphorylationSQCEKSFSGKLRLLV
CCCCCCCCCCHHHHH		41.9524719451
871UbiquitinationYECSECGKAFIRNSQ
CCCCHHHHEEHHHCE		52.35-
913PhosphorylationILSAHQRTHTGEKPC
HHHHHHCCCCCCCCE		19.74-
915PhosphorylationSAHQRTHTGEKPCKC
HHHHCCCCCCCCEEC		46.56-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZN268_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZN268_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZN268_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ZN268_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZN268_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory