NKX61_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NKX61_HUMAN
• UniProt AC: P78426
• Protein Name: Homeobox protein Nkx-6.1
• Gene Name: NKX6-1
• Organism: Homo sapiens (Human).
• Sequence Length: 367
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity)..
• Protein Sequence: MLAVGAMEGTRQSAFLLSSPPLAALHSMAEMKTPLYPAAYPPLPAGPPSSSSSSSSSSSPSPPLGTHNPGGLKPPATGGLSSLGSPPQQLSAATPHGINDILSRPSMPVASGAALPSASPSGSSSSSSSSASASSASAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPPPPGLYFSPSAAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDARLACTPHQGSILLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSETERLKGASENEEEDDDYNKPLDPNSDDEKITQLLKKHKSSSGGGGGLLLHASEPESSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	AVGAMEGTRQSAFLL CCCCCCCCCCHHHHH	16.54	29449344
51	Phosphorylation	PAGPPSSSSSSSSSS CCCCCCCCCCCCCCC	38.28	-
52	Phosphorylation	AGPPSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
53	Phosphorylation	GPPSSSSSSSSSSSP CCCCCCCCCCCCCCC	35.87	-
54	Phosphorylation	PPSSSSSSSSSSSPS CCCCCCCCCCCCCCC	35.87	-
164	Phosphorylation	LAGLPRFSSLSPPPP HCCCCCCCCCCCCCC	31.48	28348404
165	Phosphorylation	AGLPRFSSLSPPPPP CCCCCCCCCCCCCCC	30.10	28348404
167	Phosphorylation	LPRFSSLSPPPPPPG CCCCCCCCCCCCCCC	36.99	28348404
189	Asymmetric dimethylarginine	AAVAAVGRYPKPLAE HHHHHHCCCCCCHHH	37.67	-
189	Methylation	AAVAAVGRYPKPLAE HHHHHHCCCCCCHHH	37.67	24129315
211	Phosphorylation	FWPGVMQSPPWRDAR CCCCCCCCCCCCCCC	18.16	28348404
293	Acetylation	NRRTKWRKKHAAEMA CCCHHHHHHHHHHHH	48.04	30590765
294	Acetylation	RRTKWRKKHAAEMAT CCHHHHHHHHHHHHH	29.87	30590771
301	Phosphorylation	KHAAEMATAKKKQDS HHHHHHHHHHHHHHH	37.39	29083192
317	Phosphorylation	TERLKGASENEEEDD HHHHCCCCCCCCCCC	50.01	28450419
334	Phosphorylation	NKPLDPNSDDEKITQ CCCCCCCCCHHHHHH	52.40	28450419
348	Phosphorylation	QLLKKHKSSSGGGGG HHHHHHHCCCCCCCC	29.47	28450419
349	Phosphorylation	LLKKHKSSSGGGGGL HHHHHHCCCCCCCCE	37.49	29978859
350	Phosphorylation	LKKHKSSSGGGGGLL HHHHHCCCCCCCCEE	48.85	29978859
361	Phosphorylation	GGLLLHASEPESSS- CCEEEEECCCCCCC-	42.83	28450419
365	Phosphorylation	LHASEPESSS----- EEECCCCCCC-----	46.74	28450419
366	Phosphorylation	HASEPESSS------ EECCCCCCC------	38.10	28450419
367	Phosphorylation	ASEPESSS------- ECCCCCCC-------	54.22	28450419

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NKX61_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NKX61_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NKX61_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NKX61_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.