RITA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RITA1_HUMAN
• UniProt AC: Q96K30
• Protein Name: RBPJ-interacting and tubulin-associated protein 1
• Gene Name: RITA1
• Organism: Homo sapiens (Human).
• Sequence Length: 269
• Subcellular Localization: Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Shuttles rapidly between the cytoplasm and the nucleus. The function of centrosome localization is still unclear.
• Protein Description: Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis..
• Protein Sequence: MKTPVELAVSGMQTLGLQHRCRGGYRVKARTSYVDETLFGSPAGTRPTPPDFDPPWVEKANRTRGVGKEASKALGAKGSCETTPSRGSTPTLTPRKKNKYRPISHTPSYCDESLFGSRSEGASFGAPRMAKGDAAKLRALLWTPPPTPRGSHSPRPREAPLRAIHPAGPSKTEPGPAADSQKLSMGGLHSSRPLKRGLSHSLTHLNVPSTGHPATSAPHTNGPQDLRPSTSGVTFRSPLVTSRARSVSISVPSTPRRGGATQKPKPPWK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
71	Phosphorylation	RGVGKEASKALGAKG CCCCHHHHHHHCCCC		23186163
79	Phosphorylation	KALGAKGSCETTPSR HHHCCCCCCCCCCCC		21712546
82	Phosphorylation	GAKGSCETTPSRGST CCCCCCCCCCCCCCC		21712546
83	Phosphorylation	AKGSCETTPSRGSTP CCCCCCCCCCCCCCC		-
85	Phosphorylation	GSCETTPSRGSTPTL CCCCCCCCCCCCCCC		21712546
86	Methylation	SCETTPSRGSTPTLT CCCCCCCCCCCCCCC		115491299
88	Phosphorylation	ETTPSRGSTPTLTPR CCCCCCCCCCCCCCC		21712546
89	Phosphorylation	TTPSRGSTPTLTPRK CCCCCCCCCCCCCCC		21712546
91	Phosphorylation	PSRGSTPTLTPRKKN CCCCCCCCCCCCCCC		24719451
93	Phosphorylation	RGSTPTLTPRKKNKY CCCCCCCCCCCCCCC		24719451
100	Phosphorylation	TPRKKNKYRPISHTP CCCCCCCCCCCCCCC		28111955
104	Phosphorylation	KNKYRPISHTPSYCD CCCCCCCCCCCCCCC		28111955
106	Phosphorylation	KYRPISHTPSYCDES CCCCCCCCCCCCCHH		28111955
108	Phosphorylation	RPISHTPSYCDESLF CCCCCCCCCCCHHHC		28111955
109	Phosphorylation	PISHTPSYCDESLFG CCCCCCCCCCHHHCC		24719451
113	Phosphorylation	TPSYCDESLFGSRSE CCCCCCHHHCCCCCC		28111955
117	Phosphorylation	CDESLFGSRSEGASF CCHHHCCCCCCCCCC		28111955
119	Phosphorylation	ESLFGSRSEGASFGA HHHCCCCCCCCCCCC		28111955
123	Phosphorylation	GSRSEGASFGAPRMA CCCCCCCCCCCCCCC		28111955
131	Acetylation	FGAPRMAKGDAAKLR CCCCCCCCCCHHHHH		176504999
136	Acetylation	MAKGDAAKLRALLWT CCCCCHHHHHHHHCC		176505001
143	Phosphorylation	KLRALLWTPPPTPRG HHHHHHCCCCCCCCC		28857561
147	Phosphorylation	LLWTPPPTPRGSHSP HHCCCCCCCCCCCCC		23090842
149	Methylation	WTPPPTPRGSHSPRP CCCCCCCCCCCCCCC		115491293
151	Phosphorylation	PPPTPRGSHSPRPRE CCCCCCCCCCCCCCC		27174698
153	Phosphorylation	PTPRGSHSPRPREAP CCCCCCCCCCCCCCC		27174698
201	Phosphorylation	LKRGLSHSLTHLNVP CCCCCCCCCCCCCCC		30576142
229	Phosphorylation	GPQDLRPSTSGVTFR CCCCCCCCCCCCEEC		30576142
234	Phosphorylation	RPSTSGVTFRSPLVT CCCCCCCEECCCCCC		30576142
246	Phosphorylation	LVTSRARSVSISVPS CCCCCCEEEEEECCC		27050516
248	Phosphorylation	TSRARSVSISVPSTP CCCCEEEEEECCCCC		25849741
250	Phosphorylation	RARSVSISVPSTPRR CCEEEEEECCCCCCC		29978859
253	Phosphorylation	SVSISVPSTPRRGGA EEEEECCCCCCCCCC		29978859
254	Phosphorylation	VSISVPSTPRRGGAT EEEECCCCCCCCCCC		27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RITA1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RITA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RITA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.