TGFA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TGFA_HUMAN
• UniProt AC: P01135
• Protein Name: Protransforming growth factor alpha
• Gene Name: TGFA
• Organism: Homo sapiens (Human).
• Sequence Length: 160
• Subcellular Localization: Transforming growth factor alpha: Secreted, extracellular space.; Protransforming growth factor alpha: Cell membrane; Single-pass type I membrane protein.
• Protein Description: TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar..
• Protein Sequence: MVPSAGQLALFALGIVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	N-linked_Glycosylation	AACQALENSTSPLSA HHHHHHHCCCCCCCC	51.98	UniProtKB CARBOHYD
153	S-palmitoylation	LLKGRTACCHSETVV HHCCCCEECCCCCCC	1.80	8910478
154	S-palmitoylation	LKGRTACCHSETVV- HCCCCEECCCCCCC-	3.52	8910478

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TGFA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TGFA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TGFA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NKD2_HUMAN	NKD2	physical	18757723
ERBB2_HUMAN	ERBB2	physical	25241761
ADA17_HUMAN	ADAM17	physical	25241761
DLG1_HUMAN	DLG1	physical	18930083
ADA17_HUMAN	ADAM17	physical	18930083

Drug and Disease Associations

• Kegg Disease
• H00017: Esophageal cancer
• H00018: Gastric cancer
• H00516: Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Palmitoylation

"Cysteines 153 and 154 of transmembrane transforming growth factor-alpha are palmitoylated and mediate cytoplasmic protein association.";
Shum L., Turck C.W., Derynck R.;
J. Biol. Chem. 271:28502-28508(1996).
Cited for: PALMITOYLATION AT CYS-153 AND CYS-154.
PubMed: 8910478