KCNJ2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCNJ2_HUMAN
• UniProt AC: P63252
• Protein Name: Inward rectifier potassium channel 2
• Gene Name: KCNJ2
• Organism: Homo sapiens (Human).
• Sequence Length: 427
• Subcellular Localization: Membrane; Multi-pass membrane protein. Membrane; Lipid-anchor .
• Protein Description: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium..
• Protein Sequence: MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGSVRTNRY ------CCCCCCCCE		25043870
3	Phosphorylation	-----MGSVRTNRYS -----CCCCCCCCEE		29514088
6	Phosphorylation	--MGSVRTNRYSIVS --CCCCCCCCEEEEE		22199227
9	Phosphorylation	GSVRTNRYSIVSSEE CCCCCCCEEEEECCC		22199227
10	Phosphorylation	SVRTNRYSIVSSEED CCCCCCEEEEECCCH		22199227
13	Phosphorylation	TNRYSIVSSEEDGMK CCCEEEEECCCHHHH		22199227
14	Phosphorylation	NRYSIVSSEEDGMKL CCEEEEECCCHHHHH		22199227
76	S-nitrosocysteine	LADIFTTCVDIRWRW HHHHHHHHHHHHHHH		-
76	S-nitrosylation	LADIFTTCVDIRWRW HHHHHHHHHHHHHHH		19608980
242	Phosphorylation	RITSEGEYIPLDQID CCCCCCCEEEHHHEE		22817900
336	Phosphorylation	VLFEEKHYYKVDYSR EECEEEEEEEEEHHH		-
337	Phosphorylation	LFEEKHYYKVDYSRF ECEEEEEEEEEHHHC		22817900
338	Ubiquitination	FEEKHYYKVDYSRFH CEEEEEEEEEHHHCC		29967540
341	Phosphorylation	KHYYKVDYSRFHKTY EEEEEEEHHHCCCEE		-
342	Phosphorylation	HYYKVDYSRFHKTYE EEEEEEHHHCCCEEE		-
346	Ubiquitination	VDYSRFHKTYEVPNT EEHHHCCCEEECCCC		29967540
366	Phosphorylation	RDLAEKKYILSNANS HHHHHHHHHHHCCCC		-
425	Phosphorylation	PRPLRRESEI----- CCCCCCCCCC-----		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
425	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	SH3RF1	Q7Z6J0	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCNJ2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCNJ2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of KCNJ2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• H00720: Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
• H00725: Short QT syndrome
• H00731: Atrial fibrillation
• H00748: Andersen-Tawil syndrome (ATS)
• OMIM Disease
• 170390: Long QT syndrome 7 (LQT7)
• 609622: Short QT syndrome 3 (SQT3)
• 613980: Atrial fibrillation, familial, 9 (ATFB9)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.