| UniProt ID | KCJ12_HUMAN | |
|---|---|---|
| UniProt AC | Q14500 | |
| Protein Name | ATP-sensitive inward rectifier potassium channel 12 | |
| Gene Name | KCNJ12 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 433 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein. Cell membrane Multi-pass membrane protein. |
|
| Protein Description | Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.. | |
| Protein Sequence | MTAASRANPYSIVSSEEDGLHLVTMSGANGFGNGKVHTRRRCRNRFVKKNGQCNIEFANMDEKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGIIFWVIAVAHGDLEPAEGRGRTPCVMQVHGFMAAFLFSIETQTTIGYGLRCVTEECPVAVFMVVAQSIVGCIIDSFMIGAIMAKMARPKKRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRVTEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEIDEASPLFGISRQDLETDDFEIVVILEGMVEATAMTTQARSSYLANEILWGHRFEPVLFEEKNQYKIDYSHFHKTYEVPSTPRCSAKDLVENKFLLPSANSFCYENELAFLSRDEEDEADGDQDGRSRDGLSPQARHDFDRLQAGGGVLEQRPYRRESEI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 38 | Phosphorylation | FGNGKVHTRRRCRNR CCCCCCCCCHHHHHH | 22817900 | ||
| 64 | Phosphorylation | FANMDEKSQRYLADM ECCCCHHHHHHHHHH | - | ||
| 75 | S-nitrosocysteine | LADMFTTCVDIRWRY HHHHHHHHHHHHHHH | - | ||
| 75 | S-nitrosylation | LADMFTTCVDIRWRY HHHHHHHHHHHHHHH | - | ||
| 152 | Phosphorylation | GYGLRCVTEECPVAV CCCCEECCCCCCCHH | 24425749 | ||
| 193 | Phosphorylation | RPKKRAQTLLFSHNA CCHHHHHHHHCCCCE | 28450419 | ||
| 354 | Phosphorylation | KTYEVPSTPRCSAKD CEECCCCCCCCCHHH | 22817900 | ||
| 366 | Ubiquitination | AKDLVENKFLLPSAN HHHHHHCCCCCCCCC | 21963094 | ||
| 400 | Phosphorylation | DGDQDGRSRDGLSPQ CCCCCCCCCCCCCHH | 26425664 | ||
| 405 | Phosphorylation | GRSRDGLSPQARHDF CCCCCCCCHHHHHCH | 23663014 | ||
| 431 | Phosphorylation | QRPYRRESEI----- CCCCCCCCCC----- | 11181181 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 64 | S | Phosphorylation | Kinase | PKC-FAMILY | - | GPS |
| 354 | T | Phosphorylation | Kinase | PKC-FAMILY | - | GPS |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KCJ12_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KCJ12_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| DLG1_HUMAN | DLG1 | physical | 15024025 | |
| DLG4_HUMAN | DLG4 | physical | 15024025 | |
| MPP6_HUMAN | MPP6 | physical | 15024025 | |
| APBA1_HUMAN | APBA1 | physical | 15024025 | |
| CSKP_HUMAN | CASK | physical | 15024025 | |
| DLG3_HUMAN | DLG3 | physical | 15024025 | |
| DLG2_HUMAN | DLG2 | physical | 15024025 | |
| LIN7A_HUMAN | LIN7A | physical | 15024025 | |
| LIN7C_HUMAN | LIN7C | physical | 15024025 | |
| LIN7B_HUMAN | LIN7B | physical | 15024025 | |
| ABLM1_HUMAN | ABLIM1 | physical | 15024025 | |
| DMD_HUMAN | DMD | physical | 15024025 | |
| SNTA1_HUMAN | SNTA1 | physical | 15024025 | |
| SNTB1_HUMAN | SNTB1 | physical | 15024025 | |
| SNTB2_HUMAN | SNTB2 | physical | 15024025 | |
| DTNA_HUMAN | DTNA | physical | 15024025 | |
| CSKP_HUMAN | CASK | physical | 14960569 | |
| DLG1_HUMAN | DLG1 | physical | 14960569 | |
| DLG4_HUMAN | DLG4 | physical | 14960569 | |
| APBA1_HUMAN | APBA1 | physical | 14960569 | |
| LIN7A_HUMAN | LIN7A | physical | 14960569 | |
| LIN7B_HUMAN | LIN7B | physical | 14960569 | |
| LIN7C_HUMAN | LIN7C | physical | 14960569 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| D00631 | Bepridil hydrochloride hydrate (JAN); Bepridil hydrochloride (USAN); Vascor (TN) | |||||
| D00636 | Amiodarone hydrochloride (JP16/USAN); Ancaron (TN); Cordarone (TN) | |||||
| D01856 | Nifekalant hydrochloride (JAN); MS 551; Shinbit (TN) | |||||
| D02910 | Amiodarone (USAN/INN) | |||||
| D07520 | Bepridil (INN); Bepadin (TN) | |||||
| D09757 | Terikalant (INN) | |||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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