NAL13_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NAL13_HUMAN
• UniProt AC: Q86W25
• Protein Name: NACHT, LRR and PYD domains-containing protein 13
• Gene Name: NLRP13
• Organism: Homo sapiens (Human).
• Sequence Length: 1043
• Protein Description: Involved in inflammation..
• Protein Sequence: MNFSVITCPNGGTNQGLLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNLSFLLDEHFPKGQAWKVVLGIFQTMNLTSLCEKVRAEMKENVQTQELQDPTQEDLEMLEAAAGNMQTQGCQDPNQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENMKAELLETWDNISWPKDHVYIRNTSKDEHEELQRLLDPNRTRAQAQTIVLVGRAGVGKTTLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGFEEIIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQWRALCSLAIEGLWSMNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQEFFAAMSFVLEEPREFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVMEELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQASSFCLKHCKRLNKLRLSVSSHILERDLEILETSKFDSRMHAWNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIALQGNSKLTHLNFSSNKLGMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEALKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKLG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
224	Phosphorylation	RLLDPNRTRAQAQTI HHHCCCCHHHHHCEE	36.68	27174698
230	Phosphorylation	RTRAQAQTIVLVGRA CHHHHHCEEEEECCC	18.97	27174698
243	Phosphorylation	RAGVGKTTLAMQAML CCCCCHHHHHHHHHH	18.92	24719451
286	Phosphorylation	TTFAELISLDWPDFD CCHHHHHCCCCCCCC	32.66	30278072
301	Phosphorylation	APIEEFMSQPEKLLF CCHHHHHCCCCCEEE	48.15	22468782
347	Phosphorylation	PVTKILHSLLKKELV CHHHHHHHHHHCCCH	31.77	24719451
350	Acetylation	KILHSLLKKELVPLA HHHHHHHHCCCHHHH	49.87	21466224
358	Phosphorylation	KELVPLATLLITIKT CCCHHHHHHHHHHHH	29.76	17924679
402	Phosphorylation	FMRHFDDSSEVEKIL EEHHCCCHHHHHHHH	30.18	29514088
403	Phosphorylation	MRHFDDSSEVEKILQ EHHCCCHHHHHHHHH	53.29	29514088
562	Acetylation	EFPPHSTKPQEMKML CCCCCCCCHHHHHHH	47.95	18603105
567	Acetylation	STKPQEMKMLLQHVL CCCHHHHHHHHHHHH	26.16	18603111

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NAL13_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NAL13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NAL13_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GLYM_HUMAN	SHMT2	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-358, AND MASSSPECTROMETRY.
PubMed: 17924679