dbPTM

AUGN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AUGN_HUMAN
UniProt AC	Q9H1Z8
Protein Name	Augurin
Gene Name	C2orf40
Organism	Homo sapiens (Human).
Sequence Length	148
Subcellular Localization	Secreted . Cytoplasmic vesicle, secretory vesicle .
Protein Description	Probable hormone that may induce senescence of oligodendrocyte and neural precursor cells, characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation..
Protein Sequence	MAASPARPAVLALTGLALLLLLCWGPGGISGNKLKLMLQKREAPVPTKTKVAVDENKAKEFLGSLKRQKRQLWDRTRPEVQQWYQQFLYMGFDEAKFEDDITYWLNRDRNGHEYYGDYYQRHYDEDSAIGPRSPYGFRHGASVNYDDY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	Phosphorylation	KREAPVPTKTKVAVD CCCCCCCCCCEEEEC	52.13	29396449
48	"N6,N6-dimethyllysine"	REAPVPTKTKVAVDE CCCCCCCCCEEEECH	40.03	-
48	Methylation	REAPVPTKTKVAVDE CCCCCCCCCEEEECH	40.03	-
49	Phosphorylation	EAPVPTKTKVAVDEN CCCCCCCCEEEECHH	32.98	29396449
50	"N6,N6-dimethyllysine"	APVPTKTKVAVDENK CCCCCCCEEEECHHH	29.74	-
50	Methylation	APVPTKTKVAVDENK CCCCCCCEEEECHHH	29.74	-
57	"N6,N6-dimethyllysine"	KVAVDENKAKEFLGS EEEECHHHHHHHHHH	59.81	-
57	Methylation	KVAVDENKAKEFLGS EEEECHHHHHHHHHH	59.81	-
142	Phosphorylation	YGFRHGASVNYDDY- CCCCCCCCCCCCCC-	18.58	27134283
145	Phosphorylation	RHGASVNYDDY---- CCCCCCCCCCC----	14.18	27134283

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of AUGN_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AUGN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AUGN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
UBR5_HUMAN	UBR5	physical	28856538

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AUGN_HUMAN

Related Literatures of Post-Translational Modification