ATMIN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATMIN_HUMAN
• UniProt AC: O43313
• Protein Name: ATM interactor
• Gene Name: ATMIN
• Organism: Homo sapiens (Human).
• Sequence Length: 823
• Subcellular Localization: Nucleus . Nuclear, in discrete foci during G1 phase.
• Protein Description: Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription..
• Protein Sequence: MAASEAAAAAGSAALAAGARAVPAATTGAAAAASGPWVPPGPRLRGSRPRPAGATQQPAVPAPPAGELIQPSVSELSRAVRTNILCTVRGCGKILPNSPALNMHLVKSHRLQDGIVNPTIRKDLKTGPKFYCCPIEGCPRGPERPFSQFSLVKQHFMKMHAEKKHKCSKCSNSYGTEWDLKRHAEDCGKTFRCTCGCPYASRTALQSHIYRTGHEIPAEHRDPPSKKRKMENCAQNQKLSNKTIESLNNQPIPRPDTQELEASEIKLEPSFEDSCGSNTDKQTLTTPPRYPQKLLLPKPKVALVKLPVMQFSVMPVFVPTADSSAQPVVLGVDQGSATGAVHLMPLSVGTLILGLDSEACSLKESLPLFKIANPIAGEPISTGVQVNFGKSPSNPLQELGNTCQKNSISSINVQTDLSYASQNFIPSAQWATADSSVSSCSQTDLSFDSQVSLPISVHTQTFLPSSKVTSSIAAQTDAFMDTCFQSGGVSRETQTSGIESPTDDHVQMDQAGMCGDIFESVHSSYNVATGNIISNSLVAETVTHSLLPQNEPKTLNQDIEKSAPIINFSAQNSMLPSQNMTDNQTQTIDLLSDLENILSSNLPAQTLDHRSLLSDTNPGPDTQLPSGPAQNPGIDFDIEEFFSASNIQTQTEESELSTMTTEPVLESLDIETQTDFLLADTSAQSYGCRGNSNFLGLEMFDTQTQTDLNFFLDSSPHLPLGSILKHSSFSVSTDSSDTETQTEGVSTAKNIPALESKVQLNSTETQTMSSGFETLGSLFFTSNETQTAMDDFLLADLAWNTMESQFSSVETQTSAEPHTVSNF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	Phosphorylation	PGPRLRGSRPRPAGA CCCCCCCCCCCCCCC	32.45	22798277
98	Phosphorylation	CGKILPNSPALNMHL CCCCCCCCHHHCHHH	15.03	28348404
129	Phosphorylation	KDLKTGPKFYCCPIE HCCCCCCCEEEEECC	50.76	32142685
137	Ubiquitination	FYCCPIEGCPRGPER EEEEECCCCCCCCCC	27.70	29967540
171	Phosphorylation	KHKCSKCSNSYGTEW HHCCCCCCCCCCCHH	32.33	29083192
173	Phosphorylation	KCSKCSNSYGTEWDL CCCCCCCCCCCHHHH	14.51	29083192
174	Phosphorylation	CSKCSNSYGTEWDLK CCCCCCCCCCHHHHH	32.11	29083192
176	Phosphorylation	KCSNSYGTEWDLKRH CCCCCCCCHHHHHHH	26.18	29083192
270	Phosphorylation	SEIKLEPSFEDSCGS HHCEECCCCHHCCCC	31.71	-
285	Phosphorylation	NTDKQTLTTPPRYPQ CCCCCCCCCCCCCCC	40.41	32142685
293	Ubiquitination	TPPRYPQKLLLPKPK CCCCCCCCCCCCCCC	36.28	29967540
391	Phosphorylation	VQVNFGKSPSNPLQE CEEECCCCCCCHHHH	33.66	25627689
722	Phosphorylation	SPHLPLGSILKHSSF CCCCCHHHHHHCCCE	32.22	24719451
727	Phosphorylation	LGSILKHSSFSVSTD HHHHHHCCCEEEECC	31.33	28348404
728	Phosphorylation	GSILKHSSFSVSTDS HHHHHCCCEEEECCC	22.66	28348404
730	Phosphorylation	ILKHSSFSVSTDSSD HHHCCCEEEECCCCC	19.67	28348404
732	Phosphorylation	KHSSFSVSTDSSDTE HCCCEEEECCCCCCC	25.87	28348404
733	Phosphorylation	HSSFSVSTDSSDTET CCCEEEECCCCCCCC	37.43	28348404
735	Phosphorylation	SFSVSTDSSDTETQT CEEEECCCCCCCCCC	30.15	28348404
736	Phosphorylation	FSVSTDSSDTETQTE EEEECCCCCCCCCCC	51.89	28348404
738	Phosphorylation	VSTDSSDTETQTEGV EECCCCCCCCCCCCC	42.77	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATMIN_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATMIN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATMIN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBR5_HUMAN	UBR5	physical	25092319
ATM_HUMAN	ATM	physical	25092319
WRIP1_HUMAN	WRNIP1	physical	26549024
CAN13_HUMAN	CAPN13	physical	28514442
CYTSA_HUMAN	SPECC1L	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.