CAN13_HUMAN - dbPTM
CAN13_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CAN13_HUMAN
UniProt AC Q6MZZ7
Protein Name Calpain-13
Gene Name CAPN13
Organism Homo sapiens (Human).
Sequence Length 669
Subcellular Localization
Protein Description Probable non-lysosomal thiol-protease..
Protein Sequence MAYYQEPSVETSIIKFKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDLPGGPPHFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILMVQSFSHQYAGIFRFRFWQCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDALVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCATPSGPTDTAQAMENGLVSLHAYTVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQLHKKREDGEFWMSCQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPRNDAQFNFSVQEPMEGTNVVVCVTVAVTPSNLKAEDAKFPLDFQVILAGSQRFREKFPPVFFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQTRRKSAEFLLRIFLKMPDSDRHLSSHFNLRMKGSPSEHGSQQSIFNRYAQQRLDIDATQLQGLLNQELLTGPPGDMFSLDECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQTSPGVLLSSDLWKAIENTDFLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKGLYLTEMEWMSLVMYN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMAYYQEPSVETSIIK
CCCCCCCCCEEEEEE		31.6530631047
12PhosphorylationQEPSVETSIIKFKDQ
CCCCCEEEEEEECCC		14.6024719451
17UbiquitinationETSIIKFKDQDFTTL
EEEEEEECCCCCCHH		49.8629967540
224PhosphorylationKTATKAGSLITCATP
HHHHHCCCEEEEECC		22.8124275569
227PhosphorylationTKAGSLITCATPSGP
HHCCCEEEEECCCCC		11.0324275569
230PhosphorylationGSLITCATPSGPTDT
CCEEEEECCCCCCHH		21.8224275569
251PhosphorylationGLVSLHAYTVTGAEQ
CCEEEEEEEECCHHH		7.3224275569
254PhosphorylationSLHAYTVTGAEQIQY
EEEEEEECCHHHHEE		23.9124275569
261PhosphorylationTGAEQIQYRRGWEEI
CCHHHHEECCCHHHH		12.1424275569
415PhosphorylationFQVILAGSQRFREKF
CEEEECCCHHHHHHC		16.7527251275
456PhosphorylationYHLSPGNYVVVAQTR
EEECCCCEEEEEECC		10.6718083107
466PhosphorylationVAQTRRKSAEFLLRI
EEECCHHCHHHHHHH		31.0823312004
485PhosphorylationPDSDRHLSSHFNLRM
CCCCCCHHHHCCEEE		18.6827251275
486PhosphorylationDSDRHLSSHFNLRMK
CCCCCHHHHCCEEEC		38.1627251275
495PhosphorylationFNLRMKGSPSEHGSQ
CCEEECCCCCCCCCH		21.5322617229
497PhosphorylationLRMKGSPSEHGSQQS
EEECCCCCCCCCHHH		43.8726657352
501PhosphorylationGSPSEHGSQQSIFNR
CCCCCCCCHHHHHHH		27.2723312004
509PhosphorylationQQSIFNRYAQQRLDI
HHHHHHHHHHHCCCC		15.18-
573PhosphorylationLWKRLVHYQHVFQKV
HHHHHHHHHHHHHHH		7.8827251275
583PhosphorylationVFQKVQTSPGVLLSS
HHHHHCCCCCEEECH		11.5428787133
644PhosphorylationRLEAMAKTFRNLSKD
HHHHHHHHHHHHCCC		20.4921955146
649PhosphorylationAKTFRNLSKDGKGLY
HHHHHHHCCCCCCEE		32.0525072903
656PhosphorylationSKDGKGLYLTEMEWM
CCCCCCEEEEEEEEH		21.9025072903
658PhosphorylationDGKGLYLTEMEWMSL
CCCCEEEEEEEEHHH		21.5225072903
664PhosphorylationLTEMEWMSLVMYN--
EEEEEEHHHCCCC--		20.9125072903
668PhosphorylationEWMSLVMYN------
EEHHHCCCC------		15.3925072903
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CAN13_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CAN13_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CAN13_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ZC3H4_HUMANZC3H4physical
28514442
PP1RA_HUMANPPP1R10physical
28514442
SFSWA_HUMANSFSWAPphysical
28514442
SAFB2_HUMANSAFB2physical
28514442
DIDO1_HUMANDIDO1physical
28514442
PRC2A_HUMANPRRC2Aphysical
28514442
SF01_HUMANSF1physical
28514442
ZO2_HUMANTJP2physical
28514442
EWS_HUMANEWSR1physical
28514442
SAFB1_HUMANSAFBphysical
28514442
IF4E2_HUMANEIF4E2physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CAN13_HUMAN

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Related Literatures of Post-Translational Modification

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