MAGE1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAGE1_HUMAN
• UniProt AC: Q9HCI5
• Protein Name: Melanoma-associated antigen E1
• Gene Name: MAGEE1
• Organism: Homo sapiens (Human).
• Sequence Length: 957
• Subcellular Localization: Cytoplasm, perinuclear region. Nucleus. Cell membrane. In the skeletal muscle, found at the postsynaptic membrane and is associated with a subset of myonuclei. May reside within nuclei and/or in perinuclear compartments. In peripheral nerves, colocal
• Protein Description: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex..
• Protein Sequence: MSLVSQNSRRRRRRVAKATAHNSSWGEMQAPNAPGLPADVPGSDVPQGPSDSQILQGLCASEGPSTSVLPTSAEGPSTFVPPTISEASSASGQPTISEGPGTSVLPTPSEGLSTSGPPTISKGLCTSVTLAASEGRNTSRPPTSSEEPSTSVPPTASEVPSTSLPPTPGEGTSTSVPPTAYEGPSTSVVPTPDEGPSTSVLPTPGEGPGTSVPLAATEGLSTSVQATPDEGPSTSVPPTATEGLSTPVPPTRDEGPSTSVPATPGEGPSTSVLPAASDGQSISLVPTRGKGSSTSVPPTATEGLSTSVQPTAGEGSSTSVPPTPGGGLSTSVPPTATEELSTSVPPTPGEGPSTSVLPIPGEGLSTSVPPTASDGSDTSVPPTPGEGASTLVQPTAPDGPGSSVLPNPGEGPSTLFSSSASVDRNPSKCSLVLPSPRVTKASVDSDSEGPKGAEGPIEFEVLRDCESPNSISIMGLNTSRVAITLKPQDPMEQNVAELLQFLLVKDQSKYPIRESEMREYIVKEYRNQFPEILRRAAAHLECIFRFELRELDPEAHTYILLNKLGPVPFEGLEESPNGPKMGLLMMILGQIFLNGNQAKEAEIWEMLWRMGVQRERRLSIFGNPKRLLSVEFVWQRYLDYRPVTDCKPVEYEFFWGPRSHLETTKMKILKFMAKIYNKDPMDWPEKYNEALEEDAARAFAEGWQALPHFRRPFFEEAAAEVPSPDSEVSSYSSKYAPHSWPESRLESKARKLVQLFLLMDSTKLPIPKKGILYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYTLYNRREMEETEEIVDSPNRPGNNFLMQVLSFIFIMGNHARESAVWAFLRGLGVQAGRKHVITCRYLSQRYIDSLRVPDSDPVQYEFVWGPRARLETSKMKALRYVARIHRKEPQDWPQQYREAMEDEANRADVGHRQIFVHNFR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLVSQNSR ------CCCCCHHHH	37.16	29978859
5	Phosphorylation	---MSLVSQNSRRRR ---CCCCCHHHHHHH	29.01	29978859
8	Phosphorylation	MSLVSQNSRRRRRRV CCCCCHHHHHHHHHH	21.37	-
91	Phosphorylation	ISEASSASGQPTISE HHHHHHCCCCCCCCC	39.65	22468782
95	Phosphorylation	SSASGQPTISEGPGT HHCCCCCCCCCCCCC	29.28	22468782
138	Phosphorylation	AASEGRNTSRPPTSS EECCCCCCCCCCCCC	25.42	24275569
143	Phosphorylation	RNTSRPPTSSEEPST CCCCCCCCCCCCCCC	47.79	24275569
430	Phosphorylation	DRNPSKCSLVLPSPR CCCCCCCEEEECCCC	25.83	-
435	Phosphorylation	KCSLVLPSPRVTKAS CCEEEECCCCCEEEE	22.60	24719451
442	Phosphorylation	SPRVTKASVDSDSEG CCCCEEEECCCCCCC	28.19	-
445	Phosphorylation	VTKASVDSDSEGPKG CEEEECCCCCCCCCC	40.66	28348404
467	Phosphorylation	EVLRDCESPNSISIM EEEECCCCCCCEEEE	35.39	29978859
470	Phosphorylation	RDCESPNSISIMGLN ECCCCCCCEEEEEEC	22.54	29978859
509	Ubiquitination	LLVKDQSKYPIRESE HHHCCCCCCCCCHHH	49.79	27667366
520	Phosphorylation	RESEMREYIVKEYRN CHHHHHHHHHHHHHH	10.72	-
523	Ubiquitination	EMREYIVKEYRNQFP HHHHHHHHHHHHHHH	39.20	33845483
525	Phosphorylation	REYIVKEYRNQFPEI HHHHHHHHHHHHHHH	14.78	-
734	Ubiquitination	EVSSYSSKYAPHSWP HHHHCCCCCCCCCCC	39.22	29967540
878	Phosphorylation	KHVITCRYLSQRYID CEEEEEEHHCHHHHC	16.92	18083107
883	Phosphorylation	CRYLSQRYIDSLRVP EEHHCHHHHCCCCCC	11.05	18083107
911	Acetylation	RARLETSKMKALRYV CCHHHHHHHHHHHHH	52.41	7710261

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAGE1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAGE1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAGE1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TIF1B_HUMAN	TRIM28	physical	20864041
MAGE1_HUMAN	MAGEE1	physical	14623885
EID2_HUMAN	EID2	physical	28514442
CRML_HUMAN	CRAMP1L	physical	28514442
CRCM_HUMAN	MCC	physical	28514442
YLPM1_HUMAN	YLPM1	physical	28514442
BCAS3_HUMAN	BCAS3	physical	28514442
C19L2_HUMAN	CWF19L2	physical	28514442
CP070_HUMAN	C16orf70	physical	28514442
P66B_HUMAN	GATAD2B	physical	28514442
KDIS_HUMAN	KIDINS220	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.