CKLF3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CKLF3_HUMAN
• UniProt AC: Q96MX0
• Protein Name: CKLF-like MARVEL transmembrane domain-containing protein 3
• Gene Name: CMTM3
• Organism: Homo sapiens (Human).
• Sequence Length: 182
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Sequence: MWPPDPDPDPDPEPAGGSRPGPAVPGLRALLPARAFLCSLKGRLLLAESGLSFITFICYVASSASAFLTAPLLEFLLALYFLFADAMQLNDKWQGLCWPMMDFLRCVTAALIYFAISITAIAKYSDGASKAAGVFGFFATIVFATDFYLIFNDVAKFLKQGDSADETTAHKTEEENSDSDSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
113	Phosphorylation	CVTAALIYFAISITA HHHHHHHHHHHHHHH	6.44	23879269
124	Phosphorylation	SITAIAKYSDGASKA HHHHHHHCCCCHHHH	11.72	23879269
125	Phosphorylation	ITAIAKYSDGASKAA HHHHHHCCCCHHHHH	28.94	23879269
129	Phosphorylation	AKYSDGASKAAGVFG HHCCCCHHHHHHHHH	28.49	23879269
159	Ubiquitination	NDVAKFLKQGDSADE HHHHHHHHCCCCCCC	56.20	-
167	Phosphorylation	QGDSADETTAHKTEE CCCCCCCCCCCCCHH	29.81	25072903
168	Phosphorylation	GDSADETTAHKTEEE CCCCCCCCCCCCHHH	25.39	25072903
172	Phosphorylation	DETTAHKTEEENSDS CCCCCCCCHHHCCCC	38.47	25072903
177	Phosphorylation	HKTEEENSDSDSD-- CCCHHHCCCCCCC--	41.60	30576142
179	Phosphorylation	TEEENSDSDSD---- CHHHCCCCCCC----	38.54	30576142
181	Phosphorylation	EENSDSDSD------ HHCCCCCCC------	49.53	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CKLF3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CKLF3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CKLF3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
MOB3C_HUMAN	MOB3C	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.