dbPTM

DSEL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DSEL_HUMAN
UniProt AC	Q8IZU8
Protein Name	Dermatan-sulfate epimerase-like protein
Gene Name	DSEL
Organism	Homo sapiens (Human).
Sequence Length	1212
Subcellular Localization	Membrane Multi-pass membrane protein .
Protein Description
Protein Sequence	MALMFTGHLLFLALLMFAFSTFEESVSNYSEWAVFTDDIDQFKTQKVQDFRPNQKLKKSMLHPSLYFDAGEIQAMRQKSRASHLHLFRAIRSAVTVMLSNPTYYLPPPKHADFAAKWNEIYGNNLPPLALYCLLCPEDKVAFEFVLEYMDRMVGYKDWLVENAPGDEVPIGHSLTGFATAFDFLYNLLDNHRRQKYLEKIWVITEEMYEYSKVRSWGKQLLHNHQATNMIALLTGALVTGVDKGSKANIWKQAVVDVMEKTMFLLNHIVDGSLDEGVAYGSYTAKSVTQYVFLAQRHFNINNLDNNWLKMHFWFYYATLLPGFQRTVGIADSNYNWFYGPESQLVFLDKFILKNGAGNWLAQQIRKHRPKDGPMVPSTAQRWSTLHTEYIWYDPQLTPQPPADYGTAKIHTFPNWGVVTYGAGLPNTQTNTFVSFKSGKLGGRAVYDIVHFQPYSWIDGWRSFNPGHEHPDQNSFTFAPNGQVFVSEALYGPKLSHLNNVLVFAPSPSSQCNKPWEGQLGECAQWLKWTGEEVGDAAGEIITASQHGEMVFVSGEAVSAYSSAMRLKSVYRALLLLNSQTLLVVDHIERQEDSPINSVSAFFHNLDIDFKYIPYKFMNRYNGAMMDVWDAHYKMFWFDHHGNSPMASIQEAEQAAEFKKRWTQFVNVTFQMEPTITRIAYVFYGPYINVSSCRFIDSSNPGLQISLNVNNTEHVVSIVTDYHNLKTRFNYLGFGGFASVADQGQITRFGLGTQAIVKPVRHDRIIFPFGFKFNIAVGLILCISLVILTFQWRFYLSFRKLMRWILILVIALWFIELLDVWSTCSQPICAKWTRTEAEGSKKSLSSEGHHMDLPDVVITSLPGSGAEILKQLFFNSSDFLYIRVPTAYIDIPETELEIDSFVDACEWKVSDIRSGHFRLLRGWLQSLVQDTKLHLQNIHLHEPNRGKLAQYFAMNKDKKRKFKRRESLPEQRSQMKGAFDRDAEYIRALRRHLVYYPSARPVLSLSSGSWTLKLHFFQEVLGASMRALYIVRDPRAWIYSMLYNSKPSLYSLKNVPEHLAKLFKIEGGKGKCNLNSGYAFEYEPLRKELSKSKSNAVSLLSHLWLANTAAALRINTDLLPTSYQLVKFEDIVHFPQKTTERIFAFLGIPLSPASLNQILFATSTNLFYLPYEGEISPTNTNVWKQNLPRDEIKLIENICWTLMDRLGYPKFMD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	N-linked_Glycosylation	TFEESVSNYSEWAVF HHHHHHHCCCCEEEE	42.04	UniProtKB CARBOHYD
59	Phosphorylation	PNQKLKKSMLHPSLY CCHHHHHHHCCHHHE	25.62	22210691
64	Phosphorylation	KKSMLHPSLYFDAGE HHHHCCHHHEECHHH	25.59	22210691
66	Phosphorylation	SMLHPSLYFDAGEIQ HHCCHHHEECHHHHH	12.07	22210691
79	Phosphorylation	IQAMRQKSRASHLHL HHHHHHHHHHHHHHH	25.41	29083192
92	Phosphorylation	HLFRAIRSAVTVMLS HHHHHHHHHHHHHHC	22.45	24719451
102	Phosphorylation	TVMLSNPTYYLPPPK HHHHCCCCEECCCCC	29.11	24719451
208	Phosphorylation	WVITEEMYEYSKVRS HHCCHHHHHHHHHHH	18.26	-
210	Phosphorylation	ITEEMYEYSKVRSWG CCHHHHHHHHHHHHH	9.05	-
419	Phosphorylation	FPNWGVVTYGAGLPN CCCCEEEEECCCCCC	17.52	-
558	Phosphorylation	FVSGEAVSAYSSAMR EECCHHHHHHHHHHH	28.65	-
560	Phosphorylation	SGEAVSAYSSAMRLK CCHHHHHHHHHHHHH	8.82	-
570	Phosphorylation	AMRLKSVYRALLLLN HHHHHHHHHHHHHHC	9.39	-
662	Phosphorylation	AEFKKRWTQFVNVTF HHHHHHHHHHHHEEE	19.03	-
666	N-linked_Glycosylation	KRWTQFVNVTFQMEP HHHHHHHHEEEEECC	28.53	UniProtKB CARBOHYD
676	Phosphorylation	FQMEPTITRIAYVFY EEECCCEEEEEEEEC	20.64	-
688	N-linked_Glycosylation	VFYGPYINVSSCRFI EECCCCCEEECCEEE	23.06	UniProtKB CARBOHYD
709	N-linked_Glycosylation	LQISLNVNNTEHVVS EEEEEECCCCEEEEE	48.94	UniProtKB CARBOHYD
874	N-linked_Glycosylation	ILKQLFFNSSDFLYI HHHHHHHCCCCEEEE	33.02	UniProtKB CARBOHYD
1042	Phosphorylation	AWIYSMLYNSKPSLY HHHHHHHHCCCCCHH	14.56	-
1044	Phosphorylation	IYSMLYNSKPSLYSL HHHHHHCCCCCHHHC	32.18	-
1050	Phosphorylation	NSKPSLYSLKNVPEH CCCCCHHHCCCHHHH	37.85	24719451
1091	Phosphorylation	LRKELSKSKSNAVSL HHHHHCCCCCHHHHH	37.63	22964224
1100	Phosphorylation	SNAVSLLSHLWLANT CHHHHHHHHHHHHHH	23.10	22496350
1101	Phosphorylation	NAVSLLSHLWLANTA HHHHHHHHHHHHHHH	22.46	-
1107	Phosphorylation	SHLWLANTAAALRIN HHHHHHHHHHHHHCC	16.44	-
1110	Phosphorylation	WLANTAAALRINTDL HHHHHHHHHHCCCCC	8.56	-
1117	Phosphorylation	ALRINTDLLPTSYQL HHHCCCCCCCCCEEE	6.09	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DSEL_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DSEL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DSEL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DSEL_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DSEL_HUMAN

Related Literatures of Post-Translational Modification