CCG4_HUMAN - dbPTM
CCG4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CCG4_HUMAN
UniProt AC Q9UBN1
Protein Name Voltage-dependent calcium channel gamma-4 subunit
Gene Name CACNG4
Organism Homo sapiens (Human).
Sequence Length 327
Subcellular Localization Cell membrane
Multi-pass membrane protein.
Protein Description Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state..
Protein Sequence MVRCDRGLQMLLTTAGAFAAFSLMAIAIGTDYWLYSSAHICNGTNLTMDDGPPPRRARGDLTHSGLWRVCCIEGIYKGHCFRINHFPEDNDYDHDSSEYLLRIVRASSVFPILSTILLLLGGLCIGAGRIYSRKNNIVLSAGILFVAAGLSNIIGIIVYISSNTGDPSDKRDEDKKNHYNYGWSFYFGALSFIVAETVGVLAVNIYIEKNKELRFKTKREFLKASSSSPYARMPSYRYRRRRSRSSSRSTEASPSRDVSPMGLKITGAIPMGELSMYTLSREPLKVTTAASYSPDQEASFLQVHDFFQQDLKEGFHVSMLNRRTTPV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
42N-linked_GlycosylationYSSAHICNGTNLTMD
EECCEECCCCCCCCC		60.77UniProtKB CARBOHYD
45N-linked_GlycosylationAHICNGTNLTMDDGP
CEECCCCCCCCCCCC		34.61UniProtKB CARBOHYD
107PhosphorylationLLRIVRASSVFPILS
HHHHHHHHCHHHHHH		19.23-
132PhosphorylationIGAGRIYSRKNNIVL
HCCCHHHCCCCCEEE		34.1124719451
227PhosphorylationEFLKASSSSPYARMP
HHHHHCCCCCCCCCC		32.6028348404
228PhosphorylationFLKASSSSPYARMPS
HHHHCCCCCCCCCCH		24.7128348404
230PhosphorylationKASSSSPYARMPSYR
HHCCCCCCCCCCHHH		14.5928152594
235PhosphorylationSPYARMPSYRYRRRR
CCCCCCCHHHHHHHH		16.9524719451
246PhosphorylationRRRRSRSSSRSTEAS
HHHHCCCCCCCCCCC		28.7622210691
247PhosphorylationRRRSRSSSRSTEASP
HHHCCCCCCCCCCCC		31.3422210691
249PhosphorylationRSRSSSRSTEASPSR
HCCCCCCCCCCCCCC		32.3322617229
250PhosphorylationSRSSSRSTEASPSRD
CCCCCCCCCCCCCCC		34.1727732954
253PhosphorylationSSRSTEASPSRDVSP
CCCCCCCCCCCCCCC		19.7126699800
255PhosphorylationRSTEASPSRDVSPMG
CCCCCCCCCCCCCCC		38.3225849741
259PhosphorylationASPSRDVSPMGLKIT
CCCCCCCCCCCCEEE		17.2925849741
277PhosphorylationPMGELSMYTLSREPL
ECCEEEEEECCCCCE		10.9325884760
288PhosphorylationREPLKVTTAASYSPD
CCCEEEEEECCCCCC		24.1828102081
291PhosphorylationLKVTTAASYSPDQEA
EEEEEECCCCCCCCH		24.5528102081
292PhosphorylationKVTTAASYSPDQEAS
EEEEECCCCCCCCHH		21.3527642862
293PhosphorylationVTTAASYSPDQEASF
EEEECCCCCCCCHHH		21.3624173317
299PhosphorylationYSPDQEASFLQVHDF
CCCCCCHHHEEHHHH		26.2428102081
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CCG4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CCG4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CCG4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
OCRL_HUMANOCRLphysical
26186194
ALG5_HUMANALG5physical
26186194
COQ5_HUMANCOQ5physical
26186194
APC7_HUMANANAPC7physical
26186194
RMND1_HUMANRMND1physical
26186194
RSPRY_HUMANRSPRY1physical
26186194
CNDH2_HUMANNCAPH2physical
26186194
KC1E_HUMANCSNK1Ephysical
26186194
KC1D_HUMANCSNK1Dphysical
26186194
T126B_HUMANTMEM126Bphysical
26186194
YIF1A_HUMANYIF1Aphysical
26186194
MRS2_HUMANMRS2physical
26186194
ARL10_HUMANARL10physical
26186194
MTX1_HUMANMTX1physical
26186194
D19L3_HUMANDPY19L3physical
26186194
MTX3_HUMANMTX3physical
26186194
D19L3_HUMANDPY19L3physical
28514442
MTX3_HUMANMTX3physical
28514442
ARL10_HUMANARL10physical
28514442
RMND1_HUMANRMND1physical
28514442
MTX1_HUMANMTX1physical
28514442
RSPRY_HUMANRSPRY1physical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CCG4_HUMAN

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Related Literatures of Post-Translational Modification

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