dbPTM

DUS4L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DUS4L_HUMAN
UniProt AC	O95620
Protein Name	tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like
Gene Name	DUS4L
Organism	Homo sapiens (Human).
Sequence Length	317
Subcellular Localization
Protein Description	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs..
Protein Sequence	MKSDCMQTTICQERKKDPIEMFHSGQLVKVCAPMVRYSKLAFRTLVRKYSCDLCYTPMIVAADFVKSIKARDSEFTTNQGDCPLIVQFAANDARLLSDAARIVCPYANGIDINCGCPQRWAMAEGYGACLINKPELVQDMVKQVRNQVETPGFSVSIKIRIHDDLKRTVDLCQKAEATGVSWITVHGRTAEERHQPVHYDSIKIIKENMSIPVIANGDIRSLKEAENVWRITGTDGVMVARGLLANPAMFAGYEETPLKCIWDWVDIALELGTPYMCFHQHLMYMMEKITSRQEKRVFNALSSTSAIIDYLTDHYGI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	YSKLAFRTLVRKYSC HHHHHHHHHHHHCCC	24.13	-
49	Phosphorylation	FRTLVRKYSCDLCYT HHHHHHHCCCCCCCC	12.17	-
50	Phosphorylation	RTLVRKYSCDLCYTP HHHHHHCCCCCCCCC	12.28	-
150	Phosphorylation	QVRNQVETPGFSVSI HHHHCCCCCCEEEEE	29.83	26074081
154	Phosphorylation	QVETPGFSVSIKIRI CCCCCCEEEEEEEEE	22.37	26074081
156	Phosphorylation	ETPGFSVSIKIRIHD CCCCEEEEEEEEECC	19.57	26074081
223	Ubiquitination	NGDIRSLKEAENVWR CCCCCCHHHHHCEEE	57.00	-
291	Phosphorylation	YMMEKITSRQEKRVF HHHHHHCHHHHHHHH	35.12	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DUS4L_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DUS4L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DUS4L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTPRG_HUMAN	PTPRG	physical	28514442
ULBP2_HUMAN	ULBP2	physical	28514442
RASH_HUMAN	HRAS	physical	28514442
TOP1_HUMAN	TOP1	physical	28514442
GRAN_HUMAN	GCA	physical	28514442

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DUS4L_HUMAN

Related Literatures of Post-Translational Modification