LRRC7_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRRC7_RAT
• UniProt AC: P70587
• Protein Name: Leucine-rich repeat-containing protein 7
• Gene Name: Lrrc7
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1490
• Subcellular Localization: Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.
• Protein Description: Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression (By similarity)..
• Protein Sequence: MTTKRKLIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSSLPTSIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFSELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPPTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQRLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQQPRGDEDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDESAGKVKALSCQAPWDRGQRGITLQPARLSGDCCTPWARCDQQIQDMPVPQSDPQLAWGCISGLQQERSMCAPLPVAAQSTTLPSLSGRQVEINLKRYPTPYPEDLKNMVKSVQNLVGKPSHGVRVENANPTANTEQTVKEKFEHKWPVAPKEITVEDSFVHPANEMRIGELHPSLAETPLYPPKLVLLGKDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQASSASSNTRVKVGSLQPTTKDAVHNSLWGNRIAPPFPQPLDAKPLLTQREAVPPGNLPQRPDRLPMSDAFPDNWTDGSHYDNTGFVSEEATGENANNNPLLSSKARSVPAHGRRPLIRQERIVGVPLELEQSTHRHTPETEVPPSNPWQNWTRTPSPFEDRTAFPSKLETTPTTSPLPERKDHMKEPTETPGPFSPGVPWEYHDPTPNRSLGNVFSQIHCRPDSSKGVIAISKSTERLSPLMKDIKSNKFKKSQSIDEIDVGTYKVYNIPLENYASGSDHLGSHERPDKFLGPEHGMSSMSRSQSVPMLDDEMLMYGSSKGPPQQKASMTKKVYQFDQSFNPQGAVEVKAEKRIPPPFAHNSEYVQQPGKNIAKDLVSPRAYRGYPPMEQMFSFSQPSVNEDAMVNAQFASQGPRAGFLRRADSLASSTEMAMFRRVSEPHELPPGDRYGRAAYRGGLEGQSSVSMTDPQFLKRNGRYEDEHPSYQEVKAQAGSFPAKNLTQRRPLSARSYSTESYGASQTRPVSARPTMAALLEKIPSDYNLGNYGDKTSDNSDIKTRPTPVKGEESCGKMPADWRQQLLRHIEARRLDRTPSQQSNILDNGQEDVSPSGQWNPYPLGRRDVPPDTITKKAGSHIQTLMGSQSLQHRSREQQPYEGNINKVTIQQFQSPLPIQIPSSQATRGPQPGRCLIQTKGQRSMDGYPEQFCVRIEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNLLQPGDKILQANGHSFVHMEHEKAVLLLKSFQNTVDLVIQRELTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	RGEEEIISVLDYSHC CCCCEEEEEEECCCC	23.45	-
29	Phosphorylation	EIISVLDYSHCSLQQ EEEEEEECCCCCHHH	8.99	-
52	Phosphorylation	ERTLEELYLDANQIE HHHHHHHHCCHHHHH	13.05	-
90	Phosphorylation	SLPTSIASLVNLKEL HCCHHHHHHCCCHHC	31.05	8824323
182	Ubiquitination	TLPKSMHKLAQLERL HCCHHHHHHHHHHHC	36.56	-
197	Phosphorylation	DLGNNEFSELPEVLD CCCCCCHHHHHHHHH	31.85	8824323
356	Ubiquitination	VMSLRSNKLEFLPEE EEECCCCCCCCCHHH	51.11	-
386	Phosphorylation	RLKNLPFSFTKLKEL CHHCCCCCHHHHHHH	30.02	22668510
388	Phosphorylation	KNLPFSFTKLKELAA HCCCCCHHHHHHHHH	33.98	22668510
418	Ubiquitination	TEAHPETKQRVLTNY CCCCHHHHHHHHHHH	34.15	-
425	Phosphorylation	KQRVLTNYMFPQQPR HHHHHHHHCCCCCCC	8.56	-
439	Phosphorylation	RGDEDFQSDSDSFNP CCCCCCCCCCCCCCH	38.79	28551015
441	Phosphorylation	DEDFQSDSDSFNPTL CCCCCCCCCCCCHHH	40.16	28551015
443	Phosphorylation	DFQSDSDSFNPTLWE CCCCCCCCCCHHHHH	30.76	28551015
570	Phosphorylation	INLKRYPTPYPEDLK EEEEECCCCCHHHHH	26.90	28432305
610	Ubiquitination	ANTEQTVKEKFEHKW CCCHHHHHHHHCCCC	59.58	-
666	Phosphorylation	LGKDKKESTDESEVD ECCCCCCCCCHHHCC	50.46	22673903
667	Phosphorylation	GKDKKESTDESEVDK CCCCCCCCCHHHCCH	44.89	22673903
670	Phosphorylation	KKESTDESEVDKTHC CCCCCCHHHCCHHHH	45.81	22673903
708	Phosphorylation	NTRVKVGSLQPTTKD CCCEEECCCCCCCHH	27.15	23984901
712	Phosphorylation	KVGSLQPTTKDAVHN EECCCCCCCHHHHHH	33.25	23984901
713	Phosphorylation	VGSLQPTTKDAVHNS ECCCCCCCHHHHHHH	33.34	23984901
801	Phosphorylation	LLSSKARSVPAHGRR CCCHHCCCCCCCCCC	36.99	25403869
826	Phosphorylation	VPLELEQSTHRHTPE CCCEEECCCCCCCCC	19.46	25403869
827	Phosphorylation	PLELEQSTHRHTPET CCEEECCCCCCCCCC	23.71	25403869
831	Phosphorylation	EQSTHRHTPETEVPP ECCCCCCCCCCCCCC	23.83	16641100
846	Phosphorylation	SNPWQNWTRTPSPFE CCCCCCCCCCCCCCC	32.01	16641100
850	Phosphorylation	QNWTRTPSPFEDRTA CCCCCCCCCCCCCCC	41.42	30411139
864	Phosphorylation	AFPSKLETTPTTSPL CCCCCCCCCCCCCCC	48.81	27097102
865	Phosphorylation	FPSKLETTPTTSPLP CCCCCCCCCCCCCCC	14.84	30411139
867	Phosphorylation	SKLETTPTTSPLPER CCCCCCCCCCCCCCC	37.50	27097102
868	Phosphorylation	KLETTPTTSPLPERK CCCCCCCCCCCCCCC	29.56	28551015
869	Phosphorylation	LETTPTTSPLPERKD CCCCCCCCCCCCCCC	27.24	30411139
896	Phosphorylation	SPGVPWEYHDPTPNR CCCCCCCCCCCCCCC	13.98	-
928	Phosphorylation	GVIAISKSTERLSPL CEEEEECCCCCCCHH	28.80	27097102
929	Phosphorylation	VIAISKSTERLSPLM EEEEECCCCCCCHHH	28.94	27097102
933	Phosphorylation	SKSTERLSPLMKDIK ECCCCCCCHHHHHHH	23.39	27097102
947	Phosphorylation	KSNKFKKSQSIDEID HCCCCCCCCCCCEEC	29.74	27097102
949	Phosphorylation	NKFKKSQSIDEIDVG CCCCCCCCCCEECCC	38.81	27097102
958	Phosphorylation	DEIDVGTYKVYNIPL CEECCCEEEEEEEEC	7.79	-
961	Phosphorylation	DVGTYKVYNIPLENY CCCEEEEEEEECCCC	11.83	-
977	Phosphorylation	SGSDHLGSHERPDKF CCCCCCCCCCCCCCC	28.65	25403869
992	Phosphorylation	LGPEHGMSSMSRSQS CCCCCCCCCCCCCCC	27.73	25403869
993	Phosphorylation	GPEHGMSSMSRSQSV CCCCCCCCCCCCCCC	16.34	25403869
995	Phosphorylation	EHGMSSMSRSQSVPM CCCCCCCCCCCCCCC	30.63	25403869
1010	Phosphorylation	LDDEMLMYGSSKGPP CCHHHHHHCCCCCCH	15.19	-
1012	Phosphorylation	DEMLMYGSSKGPPQQ HHHHHHCCCCCCHHH	16.05	-
1013	Phosphorylation	EMLMYGSSKGPPQQK HHHHHCCCCCCHHHH	36.95	-
1022	Phosphorylation	GPPQQKASMTKKVYQ CCHHHHHHHCCEEEE	33.74	30411139
1028	Phosphorylation	ASMTKKVYQFDQSFN HHHCCEEEEECCCCC	16.61	-
1033	Phosphorylation	KVYQFDQSFNPQGAV EEEEECCCCCCCCCE	28.92	-
1058	Phosphorylation	PFAHNSEYVQQPGKN CCCCCCHHHCCCCCC	11.90	-
1072	Phosphorylation	NIAKDLVSPRAYRGY CHHHHHCCCCHHCCC	18.90	25403869
1118	Phosphorylation	GFLRRADSLASSTEM CHHHHHHHHCCCHHH	25.50	27097102
1121	Phosphorylation	RRADSLASSTEMAMF HHHHHHCCCHHHHHH	42.98	27097102
1122	Phosphorylation	RADSLASSTEMAMFR HHHHHCCCHHHHHHH	23.84	27097102
1123	Phosphorylation	ADSLASSTEMAMFRR HHHHCCCHHHHHHHC	27.56	27097102
1132	Phosphorylation	MAMFRRVSEPHELPP HHHHHCCCCCCCCCC	43.53	25403869
1143	Phosphorylation	ELPPGDRYGRAAYRG CCCCCCCCCHHHHCC	18.72	-
1149	Methylation	RYGRAAYRGGLEGQS CCCHHHHCCCCCCCC	28.16	-
1156	Phosphorylation	RGGLEGQSSVSMTDP CCCCCCCCCCCCCCH	43.49	25403869
1157	Phosphorylation	GGLEGQSSVSMTDPQ CCCCCCCCCCCCCHH	15.43	25403869
1172	Phosphorylation	FLKRNGRYEDEHPSY HHHHCCCCCCCCCCH	29.18	-
1178	Phosphorylation	RYEDEHPSYQEVKAQ CCCCCCCCHHHHHHH	41.16	-
1179	Phosphorylation	YEDEHPSYQEVKAQA CCCCCCCHHHHHHHC	17.10	-
1188	Phosphorylation	EVKAQAGSFPAKNLT HHHHHCCCCCCCCCC	30.95	25403869
1233	Phosphorylation	ALLEKIPSDYNLGNY HHHHHCCCCCCCCCC	57.08	25403869
1235	Phosphorylation	LEKIPSDYNLGNYGD HHHCCCCCCCCCCCC	19.34	-
1240	Phosphorylation	SDYNLGNYGDKTSDN CCCCCCCCCCCCCCC	25.54	-
1288 (in isoform 4)	Phosphorylation	-	39.99	-
1288	Phosphorylation	RRLDRTPSQQSNILD HCCCCCHHHHCCCCC	39.99	10827168
1332	Phosphorylation	KAGSHIQTLMGSQSL HCHHHHHHHHCCHHH	20.36	25403869
1336	Phosphorylation	HIQTLMGSQSLQHRS HHHHHHCCHHHHCCC	11.57	27097102
1338	Phosphorylation	QTLMGSQSLQHRSRE HHHHCCHHHHCCCCC	31.52	27097102
1343	Phosphorylation	SQSLQHRSREQQPYE CHHHHCCCCCCCCCC	37.74	25403869
1349	Phosphorylation	RSREQQPYEGNINKV CCCCCCCCCCCCCEE	31.93	-
1392	Phosphorylation	IQTKGQRSMDGYPEQ EEECCCCCCCCCCCC	17.21	8824323

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
826	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
826	S	Phosphorylation	Kinase	CAMK2B	P08413	PSP
827	T	Phosphorylation	Kinase	CAMK2A	P11275	PSP
827	T	Phosphorylation	Kinase	CAMK2B	P08413	PSP
1392	S	Phosphorylation	Kinase	CAMK2B	P08413	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRRC7_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRRC7_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCC2A_HUMAN	CAMK2A	physical	11160423
KCC2G_HUMAN	CAMK2G	physical	11160423
ACTN4_HUMAN	ACTN4	physical	11160423
KCC2A_RAT	Camk2a	physical	11160423

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.