TMG4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMG4_HUMAN
• UniProt AC: Q9BZD6
• Protein Name: Transmembrane gamma-carboxyglutamic acid protein 4
• Gene Name: PRRG4
• Organism: Homo sapiens (Human).
• Sequence Length: 226
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Sequence: MFTLLVLLSQLPTVTLGFPHCARGPKASKHAGEEVFTSKEEANFFIHRRLLYNRFDLELFTPGNLERECNEELCNYEEAREIFVDEDKTIAFWQEYSAKGPTTKSDGNREKIDVMGLLTGLIAAGVFLVIFGLLGYYLCITKCNRLQHPCSSAVYERGRHTPSIIFRRPEEAALSPLPPSVEDAGLPSYEQAVALTRKHSVSPPPPYPGHTKGFRVFKKSMSLPSH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	HAGEEVFTSKEEANF CCCCCCCCCHHHHHH	44.03	22617229
38	Phosphorylation	AGEEVFTSKEEANFF CCCCCCCCHHHHHHH	26.97	25849741
58	4-carboxyglutamate	LYNRFDLELFTPGNL HHHCCCEECCCCCCH	43.62	-
66	4-carboxyglutamate	LFTPGNLERECNEEL CCCCCCHHHHHCHHH	50.89	-
68	4-carboxyglutamate	TPGNLERECNEELCN CCCCHHHHHCHHHCC	32.11	-
71	4-carboxyglutamate	NLERECNEELCNYEE CHHHHHCHHHCCHHH	65.10	-
72	Gamma-carboxyglutamic_acid	LERECNEELCNYEEA HHHHHCHHHCCHHHH	44.63	-
72	4-carboxyglutamate	LERECNEELCNYEEA HHHHHCHHHCCHHHH	44.63	-
77	4-carboxyglutamate	NEELCNYEEAREIFV CHHHCCHHHHHHHCC	31.05	-
78	4-carboxyglutamate	EELCNYEEAREIFVD HHHCCHHHHHHHCCC	42.54	-
81	4-carboxyglutamate	CNYEEAREIFVDEDK CCHHHHHHHCCCCCC	48.07	-
86	4-carboxyglutamate	AREIFVDEDKTIAFW HHHHCCCCCCCEEEE	56.98	-
102	Phosphorylation	EYSAKGPTTKSDGNR HHHCCCCCCCCCCCH	56.37	22817900
103	Phosphorylation	YSAKGPTTKSDGNRE HHCCCCCCCCCCCHH	31.52	22817900
152	Phosphorylation	RLQHPCSSAVYERGR CCCCCCCHHHHHCCC	28.59	24275569
155	Phosphorylation	HPCSSAVYERGRHTP CCCCHHHHHCCCCCC	10.30	27259358
161	Phosphorylation	VYERGRHTPSIIFRR HHHCCCCCCCEEEEC	19.85	26055452
163	Phosphorylation	ERGRHTPSIIFRRPE HCCCCCCCEEEECHH	29.48	26055452
188	Phosphorylation	VEDAGLPSYEQAVAL HHHCCCCCHHHHHHH	46.47	-
200	Phosphorylation	VALTRKHSVSPPPPY HHHHHHCCCCCCCCC	27.59	20363803
202	Phosphorylation	LTRKHSVSPPPPYPG HHHHCCCCCCCCCCC	34.40	26055452
207	Phosphorylation	SVSPPPPYPGHTKGF CCCCCCCCCCCCCCC	27.85	27794612
211	Phosphorylation	PPPYPGHTKGFRVFK CCCCCCCCCCCEEEH	38.48	27794612
212	Ubiquitination	PPYPGHTKGFRVFKK CCCCCCCCCCEEEHH	50.83	-
220	Phosphorylation	GFRVFKKSMSLPSH- CCEEEHHHCCCCCC-	17.75	27251275
222	Phosphorylation	RVFKKSMSLPSH--- EEEHHHCCCCCC---	44.19	25106551
225	Phosphorylation	KKSMSLPSH------ HHHCCCCCC------	47.31	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMG4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMG4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMG4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VEGFA_HUMAN	VEGFA	physical	21988832
UBE2K_HUMAN	UBE2K	physical	21988832
CTIP_HUMAN	RBBP8	physical	21988832
STXB4_HUMAN	STXBP4	physical	26186194
YAP1_HUMAN	YAP1	physical	26186194
YAP1_HUMAN	YAP1	physical	28514442
STXB4_HUMAN	STXBP4	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.