dbPTM

SNX29_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SNX29_HUMAN
UniProt AC	Q8TEQ0
Protein Name	Sorting nexin-29
Gene Name	SNX29
Organism	Homo sapiens (Human).
Sequence Length	813
Subcellular Localization
Protein Description
Protein Sequence	MSGSQNNDKRQFLLERLLDAVKQCQIRFGGRKEIASDSDSRVTCLCAQFEAVLQHGLKRSRGLALTAAAIKQAAGFASKTETEPVFWYYVKEVLNKHELQRFYSLRHIASDVGRGRAWLRCALNEHSLERYLHMLLADRCRLSTFYEDWSFVMDEERSSMLPTMAAGLNSILFAINIDNKDLNGQSKFAPTVSDLLKESTQNVTSLLKESTQGVSSLFREITASSAVSILIKPEQETDPLPVVSRNVSADAKCKKERKKKKKVTNIISFDDEEDEQNSGDVFKKTPGAGESSEDNSDRSSVNIMSAFESPFGPNSNGSQSSNSWKIDSLSLNGEFGYQKLDVKSIDDEDVDENEDDVYGNSSGRKHRGHSESPEKPLEGNTCLSQMHSWAPLKVLHNDSDILFPVSGVGSYSPADAPLGSLENGTGPEDHVLPDPGLRYSVEASSPGHGSPLSSLLPSASVPESMTISELRQATVAMMNRKDELEEENRSLRNLLDGEMEHSAALRQEVDTLKRKVAEQEERQGMKVQALARENEVLKVQLKKYVGAVQMLKREGQTAEVPNLWSVDGEVTVAEQKPGEIAEELASSYERKLIEVAEMHGELIEFNERLHRALVAKEALVSQMRQELIDLRGPVPGDLSQTSEDQSLSDFEISNRALINVWIPSVFLRGKAANAFHVYQVYIRIKDDEWNIYRRYTEFRSLHHKLQNKYPQVRAYNFPPKKAIGNKDAKFVEERRKQLQNYLRSVMNKVIQMVPEFAASPKKETLIQLMPFFVDITPPGEPVNSRPKAASRFPKLSRGQPRETRNVEPQSGDL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
71	Ubiquitination	ALTAAAIKQAAGFAS HHHHHHHHHHCCCCC	29.20	29967540
96	Malonylation	YVKEVLNKHELQRFY HHHHHCCHHHHHHHH	34.00	26320211
104	Phosphorylation	HELQRFYSLRHIASD HHHHHHHHHHHHHHH	19.06	24719451
163	O-linked_Glycosylation	ERSSMLPTMAAGLNS HHHCCHHHHHHHHHH	18.58	29351928
187	Ubiquitination	KDLNGQSKFAPTVSD CCCCCCCCCCCCHHH	37.34	29967540
193	Phosphorylation	SKFAPTVSDLLKEST CCCCCCHHHHHHHHC	25.64	28857561
199	Phosphorylation	VSDLLKESTQNVTSL HHHHHHHHCHHHHHH	33.43	28348404
200	Phosphorylation	SDLLKESTQNVTSLL HHHHHHHCHHHHHHH	25.84	28348404
205	Phosphorylation	ESTQNVTSLLKESTQ HHCHHHHHHHHHHHH	27.67	24719451
210	Phosphorylation	VTSLLKESTQGVSSL HHHHHHHHHHHHHHH	25.17	28857561
211	Phosphorylation	TSLLKESTQGVSSLF HHHHHHHHHHHHHHH	30.36	28857561
216	Phosphorylation	ESTQGVSSLFREITA HHHHHHHHHHHHHHH	29.17	24719451
254	Phosphorylation	VSADAKCKKERKKKK CCCCCHHHHHHHCCC	57.89	17081983
256	Phosphorylation	ADAKCKKERKKKKKV CCCHHHHHHHCCCCC	56.05	17081983
257	Phosphorylation	DAKCKKERKKKKKVT CCHHHHHHHCCCCCC	66.04	17081983
261	Phosphorylation	KKERKKKKKVTNIIS HHHHHCCCCCCEEEE	62.45	17081983
263	Phosphorylation	ERKKKKKVTNIISFD HHHCCCCCCEEEECC	7.32	17081983
264	Phosphorylation	RKKKKKVTNIISFDD HHCCCCCCEEEECCC	29.58	30624053
268	Phosphorylation	KKVTNIISFDDEEDE CCCCEEEECCCCCCH	20.87	30266825
278	Phosphorylation	DEEDEQNSGDVFKKT CCCCHHCCCCCCCCC	35.74	25159151
291	Phosphorylation	KTPGAGESSEDNSDR CCCCCCCCCCCCCCC	37.80	17081983
292	Phosphorylation	TPGAGESSEDNSDRS CCCCCCCCCCCCCCC	44.67	-
328	Phosphorylation	SNSWKIDSLSLNGEF CCCEEEEEEEECCCC	24.27	30266825
330	Phosphorylation	SWKIDSLSLNGEFGY CEEEEEEEECCCCCE	24.60	23401153
337	Phosphorylation	SLNGEFGYQKLDVKS EECCCCCEEEECCCC	14.06	23403867
344	Phosphorylation	YQKLDVKSIDDEDVD EEEECCCCCCHHHCC	30.97	23401153
358	Phosphorylation	DENEDDVYGNSSGRK CCCCCCCCCCCCCCC	19.99	25884760
361	Phosphorylation	EDDVYGNSSGRKHRG CCCCCCCCCCCCCCC	29.79	23403867
362	Phosphorylation	DDVYGNSSGRKHRGH CCCCCCCCCCCCCCC	46.76	23403867
370	Phosphorylation	GRKHRGHSESPEKPL CCCCCCCCCCCCCCC	42.46	28450419
372	Phosphorylation	KHRGHSESPEKPLEG CCCCCCCCCCCCCCC	41.18	27422710
381	Phosphorylation	EKPLEGNTCLSQMHS CCCCCCCCHHHHHHH	26.19	28450419
384	Phosphorylation	LEGNTCLSQMHSWAP CCCCCHHHHHHHCCC	27.83	28450419
388	Phosphorylation	TCLSQMHSWAPLKVL CHHHHHHHCCCEEEE	21.42	26330541
410	Phosphorylation	FPVSGVGSYSPADAP EECCCCCCCCCCCCC	21.74	25921289
411	Phosphorylation	PVSGVGSYSPADAPL ECCCCCCCCCCCCCC	16.85	25921289
412	Phosphorylation	VSGVGSYSPADAPLG CCCCCCCCCCCCCCC	18.47	28857561
420	Phosphorylation	PADAPLGSLENGTGP CCCCCCCCCCCCCCC	39.95	25921289
425	Phosphorylation	LGSLENGTGPEDHVL CCCCCCCCCCCCCCC	62.23	28348404
439	Phosphorylation	LPDPGLRYSVEASSP CCCCCCCEEEEECCC	23.31	28450419
440	Phosphorylation	PDPGLRYSVEASSPG CCCCCCEEEEECCCC	13.67	28450419
444	Phosphorylation	LRYSVEASSPGHGSP CCEEEEECCCCCCCC	24.45	30278072
445	Phosphorylation	RYSVEASSPGHGSPL CEEEEECCCCCCCCH	41.78	30278072
450	Phosphorylation	ASSPGHGSPLSSLLP ECCCCCCCCHHHHCC	19.59	30278072
453	Phosphorylation	PGHGSPLSSLLPSAS CCCCCCHHHHCCCCC	23.48	21712546
454	Phosphorylation	GHGSPLSSLLPSASV CCCCCHHHHCCCCCC	41.42	28464451
458	Phosphorylation	PLSSLLPSASVPESM CHHHHCCCCCCCCCC	32.90	28450419
460	Phosphorylation	SSLLPSASVPESMTI HHHCCCCCCCCCCCH	42.41	28450419
464	Phosphorylation	PSASVPESMTISELR CCCCCCCCCCHHHHH	18.37	20068231
466	Phosphorylation	ASVPESMTISELRQA CCCCCCCCHHHHHHH	30.54	20068231
468	Phosphorylation	VPESMTISELRQATV CCCCCCHHHHHHHHH	22.78	20068231
490	Phosphorylation	ELEEENRSLRNLLDG HHHHHHHHHHHHHHH	43.17	20071362
502	Phosphorylation	LDGEMEHSAALRQEV HHHHHHHHHHHHHHH	11.26	20071362
526	Ubiquitination	QEERQGMKVQALARE HHHHCCCHHHHHHHC	37.71	29967540
544	Phosphorylation	LKVQLKKYVGAVQML HHHHHHHHHHHHHHH	11.52	22817900
616	Ubiquitination	LHRALVAKEALVSQM HHHHHHHHHHHHHHH	35.72	-
639	Phosphorylation	GPVPGDLSQTSEDQS CCCCCCCHHCCCCCC	35.83	23401153
641	Phosphorylation	VPGDLSQTSEDQSLS CCCCCHHCCCCCCCC	30.61	22617229
642	Phosphorylation	PGDLSQTSEDQSLSD CCCCHHCCCCCCCCH	31.38	30278072
646	Phosphorylation	SQTSEDQSLSDFEIS HHCCCCCCCCHHHHC	42.01	22617229
648	Phosphorylation	TSEDQSLSDFEISNR CCCCCCCCHHHHCCH	45.56	22115753
653	Phosphorylation	SLSDFEISNRALINV CCCHHHHCCHHHHEE	17.05	28450419
709	Phosphorylation	HHKLQNKYPQVRAYN HHHHHHCCCCHHCCC	13.37	26074081
759	Phosphorylation	MVPEFAASPKKETLI HHHHHHCCCCHHHHH	33.55	22210691
764	Phosphorylation	AASPKKETLIQLMPF HCCCCHHHHHHHCEE	37.73	22210691
776	Phosphorylation	MPFFVDITPPGEPVN CEEECCCCCCCCCCC	20.97	22210691
784	Phosphorylation	PPGEPVNSRPKAASR CCCCCCCCCCCHHHC	50.63	22210691
790	Phosphorylation	NSRPKAASRFPKLSR CCCCCHHHCCCCCCC	39.04	24719451
810	Phosphorylation	TRNVEPQSGDL---- CCCCCCCCCCC----	45.02	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SNX29_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SNX29_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SNX29_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SNX29_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SNX29_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-810, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639; THR-641; SER-642;SER-646; SER-648 AND SER-810, AND MASS SPECTROMETRY.	17081983 [Abstract]