ARHGQ_HUMAN - dbPTM
ARHGQ_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ARHGQ_HUMAN
UniProt AC Q96DR7
Protein Name Rho guanine nucleotide exchange factor 26
Gene Name ARHGEF26
Organism Homo sapiens (Human).
Sequence Length 871
Subcellular Localization Cell projection, ruffle .
Protein Description Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry..
Protein Sequence MDGESEVDFSSNSITPLWRRRSIPQPHQVLGRSKPRPQSYQSPNGLLITDFPVEDGGTLLAAQIPAQVPTASDSRTVHRSPLLLGAQRRAVANGGTASPEYRAASPRLRRPKSPKLPKAVPGGSPKSPANGAVTLPAPPPPPVLRPPRTPNAPAPCTPEEDLTGLTASPVPSPTANGLAANNDSPGSGSQSGRKAKDPERGLFPGPQKSSSEQKLPLQRLPSQENELLENPSVVLSTNSPAALKVGKQQIIPKSLASEIKISKSNNQNVEPHKRLLKVRSMVEGLGGPLGHAGEESEVDNDVDSPGSLRRGLRSTSYRRAVVSGFDFDSPTSSKKKNRMSQPVLKVVMEDKEKFSSLGRIKKKMLKGQGTFDGEENAVLYQNYKEKALDIDSDEESEPKEQKSDEKIVIHHKPLRSTWSQLSAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTERHHLFSNITDVCEASKKFFIELEARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYVEDTVLFSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNEELNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVEMLLGAETQSERARWITALGHSSGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKEITCQATIDKNVERMGRLLGLETNV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
22PhosphorylationTPLWRRRSIPQPHQV
CHHHHCCCCCCCHHC		36.4930266825
76PhosphorylationPTASDSRTVHRSPLL
CCCCCCCCCCCCCCH		25.3129978859
79MethylationSDSRTVHRSPLLLGA
CCCCCCCCCCCHHHH		35.3230763163
79DimethylationSDSRTVHRSPLLLGA
CCCCCCCCCCCHHHH		35.32-
80PhosphorylationDSRTVHRSPLLLGAQ
CCCCCCCCCCHHHHH		12.6719664994
96PhosphorylationRAVANGGTASPEYRA
HHHHCCCCCCHHHHC		25.9229255136
98PhosphorylationVANGGTASPEYRAAS
HHCCCCCCHHHHCCC		20.3629255136
101PhosphorylationGGTASPEYRAASPRL
CCCCCHHHHCCCCCC		14.6727259358
105PhosphorylationSPEYRAASPRLRRPK
CHHHHCCCCCCCCCC		15.0122199227
113PhosphorylationPRLRRPKSPKLPKAV
CCCCCCCCCCCCCCC		29.9224719451
124PhosphorylationPKAVPGGSPKSPANG
CCCCCCCCCCCCCCC		34.7623312004
127PhosphorylationVPGGSPKSPANGAVT
CCCCCCCCCCCCCCC		32.4029449344
134PhosphorylationSPANGAVTLPAPPPP
CCCCCCCCCCCCCCC		26.8729449344
163PhosphorylationCTPEEDLTGLTASPV
CCCHHHCCCCCCCCC		42.3329449344
166PhosphorylationEEDLTGLTASPVPSP
HHHCCCCCCCCCCCC		26.8329449344
168PhosphorylationDLTGLTASPVPSPTA
HCCCCCCCCCCCCCC		22.6129449344
172PhosphorylationLTASPVPSPTANGLA
CCCCCCCCCCCCCCC		34.8129449344
174PhosphorylationASPVPSPTANGLAAN
CCCCCCCCCCCCCCC		36.7729449344
209PhosphorylationLFPGPQKSSSEQKLP
CCCCCCCCCCCCCCC		33.5721406692
210PhosphorylationFPGPQKSSSEQKLPL
CCCCCCCCCCCCCCH		44.9521406692
211PhosphorylationPGPQKSSSEQKLPLQ
CCCCCCCCCCCCCHH		51.6521406692
222PhosphorylationLPLQRLPSQENELLE
CCHHCCCCCCCHHHC		55.5127273156
232PhosphorylationNELLENPSVVLSTNS
CHHHCCCCEEEECCC		36.1229507054
236PhosphorylationENPSVVLSTNSPAAL
CCCCEEEECCCHHHH		17.5822199227
237PhosphorylationNPSVVLSTNSPAALK
CCCEEEECCCHHHHH		35.2425850435
239PhosphorylationSVVLSTNSPAALKVG
CEEEECCCHHHHHHC		18.9222199227
260UbiquitinationKSLASEIKISKSNNQ
HHHHHCEEECCCCCC		36.55-
280PhosphorylationKRLLKVRSMVEGLGG
HHHHHHHHHHHCCCC		30.1224719451
304PhosphorylationEVDNDVDSPGSLRRG
CCCCCCCCCCHHHHH		30.8922496350
307PhosphorylationNDVDSPGSLRRGLRS
CCCCCCCHHHHHHHC		23.3030624053
316PhosphorylationRRGLRSTSYRRAVVS
HHHHHCCCHHEHHHC		20.21-
317PhosphorylationRGLRSTSYRRAVVSG
HHHHCCCHHEHHHCC		12.28-
323PhosphorylationSYRRAVVSGFDFDSP
CHHEHHHCCCCCCCC		27.4325850435
329PhosphorylationVSGFDFDSPTSSKKK
HCCCCCCCCCCHHHC		30.0330266825
331PhosphorylationGFDFDSPTSSKKKNR
CCCCCCCCCHHHCCC		49.9730243723
332PhosphorylationFDFDSPTSSKKKNRM
CCCCCCCCHHHCCCC		43.4730266825
333PhosphorylationDFDSPTSSKKKNRMS
CCCCCCCHHHCCCCC		51.4730266825
340PhosphorylationSKKKNRMSQPVLKVV
HHHCCCCCCCCHHHH		28.2622617229
355PhosphorylationMEDKEKFSSLGRIKK
HCCHHHHHHHHHHHH		35.4024719451
356PhosphorylationEDKEKFSSLGRIKKK
CCHHHHHHHHHHHHH		37.6729514088
370PhosphorylationKMLKGQGTFDGEENA
HHHCCCCCCCCCCCE		15.6321945579
380PhosphorylationGEENAVLYQNYKEKA
CCCCEEEEECHHHHH		6.5221945579
383PhosphorylationNAVLYQNYKEKALDI
CEEEEECHHHHHCCC		12.6621945579
392PhosphorylationEKALDIDSDEESEPK
HHHCCCCCCCCCCCC		47.4529255136
396PhosphorylationDIDSDEESEPKEQKS
CCCCCCCCCCCCCCC		58.0928176443
416PhosphorylationIHHKPLRSTWSQLSA
EECHHCCCHHHHHHH		41.7429514088
417PhosphorylationHHKPLRSTWSQLSAV
ECHHCCCHHHHHHHH		23.7729514088
419PhosphorylationKPLRSTWSQLSAVKR
HHCCCHHHHHHHHHH		22.7222617229
422 (in isoform 3)Phosphorylation-24.3128842319
422PhosphorylationRSTWSQLSAVKRKGL
CCHHHHHHHHHHHCC		24.3122617229
432PhosphorylationKRKGLSQTVSQEERK
HHHCCCCCCCHHHHH		20.8128348404
434PhosphorylationKGLSQTVSQEERKRQ
HCCCCCCCHHHHHHH		34.9528348404
515PhosphorylationNIFIDDISDIVEKHT
CEECCCHHHHHHHHC		28.4224719451
531UbiquitinationSTFDPYVKYCTNEVY
CCCCHHHHHHCHHHH		28.85-
532PhosphorylationTFDPYVKYCTNEVYQ
CCCHHHHHHCHHHHH		8.41-
538PhosphorylationKYCTNEVYQQRTLQK
HHHCHHHHHHHHHHH		7.86-
552PhosphorylationKLLATNPSFKEVLSR
HHHHCCCCHHHHHHH		51.5330631047
558PhosphorylationPSFKEVLSRIESHED
CCHHHHHHHHHCCHH		36.0730631047
611AcetylationEVCKRALKEVSKLVR
HHHHHHHHHHHHHHH		55.907338949
663PhosphorylationLVKRGELTAYVEDTV
EEECCEEEEEEEEEE		16.1924732914
665PhosphorylationKRGELTAYVEDTVLF
ECCEEEEEEEEEEEE		10.1124732914
669PhosphorylationLTAYVEDTVLFSRRT
EEEEEEEEEEEECCC		12.9524732914
673PhosphorylationVEDTVLFSRRTSKQQ
EEEEEEEECCCCCCC		19.3824732914
707PhosphorylationSYNVNDYSLRDQLLV
CCCCCCCCHHHHEEE		21.5724719451
724PhosphorylationCDNEELNSSPGKNSS
CCCCHHHCCCCCCCC		51.0027690223
725PhosphorylationDNEELNSSPGKNSST
CCCHHHCCCCCCCCC		36.2828985074
732PhosphorylationSPGKNSSTMLYSRQS
CCCCCCCCCEEECCC		15.8327690223
735PhosphorylationKNSSTMLYSRQSSAS
CCCCCCEEECCCCHH		7.3222817900
736PhosphorylationNSSTMLYSRQSSASH
CCCCCEEECCCCHHH		21.6324719451
739PhosphorylationTMLYSRQSSASHLFT
CCEEECCCCHHHHHH		27.1129523821
740PhosphorylationMLYSRQSSASHLFTL
CEEECCCCHHHHHHH		26.0026657352
742PhosphorylationYSRQSSASHLFTLTV
EECCCCHHHHHHHHH		23.7524719451
775PhosphorylationSERARWITALGHSSG
HHHHHHHHHHHCCCC		14.63-
780PhosphorylationWITALGHSSGKPPAD
HHHHHHCCCCCCCCC		38.70-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ARHGQ_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ARHGQ_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ARHGQ_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MUTA_HUMANMUTphysical
26186194
IF2M_HUMANMTIF2physical
26186194
SYAM_HUMANAARS2physical
26186194
CPSM_HUMANCPS1physical
26186194
CPT2_HUMANCPT2physical
26186194
PDPR_HUMANPDPRphysical
26186194
SYDM_HUMANDARS2physical
26186194
SIR3_HUMANSIRT3physical
26186194
IF2M_HUMANMTIF2physical
28514442
CPSM_HUMANCPS1physical
28514442
CPT2_HUMANCPT2physical
28514442
PDPR_HUMANPDPRphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ARHGQ_HUMAN

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-222 AND SER-392, ANDMASS SPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory