GCNT3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GCNT3_HUMAN
• UniProt AC: O95395
• Protein Name: Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
• Gene Name: GCNT3
• Organism: Homo sapiens (Human).
• Sequence Length: 438
• Subcellular Localization: Golgi apparatus membrane; Single-pass type II membrane protein.
• Protein Description: Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development..
• Protein Sequence: MVQWKRLCQLHYLWALGCYMLLATVALKLSFRLKCDSDHLGLESRESQSQYCRNILYNFLKLPAKRSINCSGVTRGDQEAVLQAILNNLEVKKKREPFTDTHYLSLTRDCEHFKAERKFIQFPLSKEEVEFPIAYSMVIHEKIENFERLLRAVYAPQNIYCVHVDEKSPETFKEAVKAIISCFPNVFIASKLVRVVYASWSRVQADLNCMEDLLQSSVPWKYFLNTCGTDFPIKSNAEMVQALKMLNGRNSMESEVPPKHKETRWKYHFEVVRDTLHLTNKKKDPPPYNLTMFTGNAYIVASRDFVQHVLKNPKSQQLIEWVKDTYSPDEHLWATLQRARWMPGSVPNHPKYDISDMTSIARLVKWQGHEGDIDKGAPYAPCSGIHQRAICVYGAGDLNWMLQNHHLLANKFDPKVDDNALQCLEEYLRYKAIYGTEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	YLWALGCYMLLATVA HHHHHHHHHHHHHHH	6.76	-
30	Phosphorylation	ATVALKLSFRLKCDS HHHHHHHHHHHCCCC	13.51	25554490
37	Phosphorylation	SFRLKCDSDHLGLES HHHHCCCCCCCCCCC	36.08	22210691
74	Phosphorylation	SINCSGVTRGDQEAV CCCCCCCCCCCHHHH	32.24	23532336
105	Phosphorylation	FTDTHYLSLTRDCEH CCCHHHHEEECCCHH	22.11	24719451
251	Phosphorylation	KMLNGRNSMESEVPP HHHCCCCCCCCCCCC	23.67	22210691
267	Phosphorylation	HKETRWKYHFEVVRD CCCCHHEEEEEEHHH	12.55	-
288	Phosphorylation	KKKDPPPYNLTMFTG CCCCCCCCEEEEEEC	28.69	28122231
289	N-linked_Glycosylation	KKDPPPYNLTMFTGN CCCCCCCEEEEEECC	34.51	UniProtKB CARBOHYD
291	Phosphorylation	DPPPYNLTMFTGNAY CCCCCEEEEEECCEE	13.44	28122231
294	Phosphorylation	PYNLTMFTGNAYIVA CCEEEEEECCEEEEE	20.78	28122231
298	Phosphorylation	TMFTGNAYIVASRDF EEEECCEEEEECHHH	10.42	28122231
302	Phosphorylation	GNAYIVASRDFVQHV CCEEEEECHHHHHHH	22.84	28122231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GCNT3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GCNT3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GCNT3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPN1_HUMAN	SNUPN	physical	21988832
RBM18_HUMAN	RBM18	physical	21988832
HERC1_HUMAN	HERC1	physical	28514442
CXCR4_HUMAN	CXCR4	physical	28514442
CUL4B_HUMAN	CUL4B	physical	28514442
RSPRY_HUMAN	RSPRY1	physical	28514442
BCKD_HUMAN	BCKDK	physical	28514442
SORL_HUMAN	SORL1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.