TBR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBR1_HUMAN
• UniProt AC: Q16650
• Protein Name: T-box brain protein 1
• Gene Name: TBR1
• Organism: Homo sapiens (Human).
• Sequence Length: 682
• Subcellular Localization: Nucleus .
• Protein Description: Probable transcriptional regulator involved in developmental processes. Required for normal brain development..
• Protein Sequence: MQLEHCLSPSIMLSKKFLNVSSSYPHSGGSELVLHDHPIISTTDNLERSSPLKKITRGMTNQSDTDNFPDSKDSPGDVQRSKLSPVLDGVSELRHSFDGSAADRYLLSQSSQPQSAATAPSAMFPYPGQHGPAHPAFSIGSPSRYMAHHPVITNGAYNSLLSNSSPQGYPTAGYPYPQQYGHSYQGAPFYQFSSTQPGLVPGKAQVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQGGKWVPCGKADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQMVVLQSLHKYQPRLHVVEVNEDGTEDTSQPGRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDTIYTGCDMDRLTPSPNDSPRSQIVPGARYAMAGSFLQDQFVSNYAKARFHPGAGAGPGPGTDRSVPHTNGLLSPQQAEDPGAPSPQRWFVTPANNRLDFAASAYDTATDFAGNAATLLSYAAAGVKALPLQAAGCTGRPLGYYADPSGWGARSPPQYCGTKSGSVLPCWPNSAAAAARMAGANPYLGEEAEGLAAERSPLPPGAAEDAKPKDLSDSSWIETPSSIKSIDSSDSGIYEQAKRRRISPADTPVSESSSPLKSEVLAQRDCEKNCAKDISGYYGFYSHS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
74	Phosphorylation	NFPDSKDSPGDVQRS CCCCCCCCCCHHHHH	34.22	22617229
81	Phosphorylation	SPGDVQRSKLSPVLD CCCHHHHHHCHHHHC	22.36	25307156
84	Phosphorylation	DVQRSKLSPVLDGVS HHHHHHCHHHHCHHH	19.39	25307156
91	Phosphorylation	SPVLDGVSELRHSFD HHHHCHHHHHHHHCC	36.12	21712546
228	Ubiquitination	QTEMIITKQGRRMFP CCEEEEEECCCCCCC	40.11	-
287	Phosphorylation	NVQGNRVYMHPDSPN CCCCCEEEECCCCCC	6.10	29083192
292	Phosphorylation	RVYMHPDSPNTGAHW EEEECCCCCCCCCCC	25.22	29083192
295	Phosphorylation	MHPDSPNTGAHWMRQ ECCCCCCCCCCCCCE	38.85	29083192
305	Phosphorylation	HWMRQEISFGKLKLT CCCCEEEECCEEEEC	27.48	29083192
408	Phosphorylation	GCDMDRLTPSPNDSP CCCHHHCCCCCCCCC	23.71	22617229
410	Phosphorylation	DMDRLTPSPNDSPRS CHHHCCCCCCCCCHH	30.97	22617229
414	Phosphorylation	LTPSPNDSPRSQIVP CCCCCCCCCHHHCCC	28.93	22617229
417	Phosphorylation	SPNDSPRSQIVPGAR CCCCCCHHHCCCCHH	27.87	26434552
425	Phosphorylation	QIVPGARYAMAGSFL HCCCCHHHHHCHHHH	10.53	26434552
430	Phosphorylation	ARYAMAGSFLQDQFV HHHHHCHHHHHHHHH	17.16	-
438	Phosphorylation	FLQDQFVSNYAKARF HHHHHHHHHHHHHHC	25.97	26434552
440	Phosphorylation	QDQFVSNYAKARFHP HHHHHHHHHHHHCCC	11.28	-
464	Phosphorylation	TDRSVPHTNGLLSPQ CCCCCCCCCCCCCHH	25.55	22617229
480	Phosphorylation	AEDPGAPSPQRWFVT CCCCCCCCCCCEEEE	32.88	22617229
543	Phosphorylation	LGYYADPSGWGARSP CCEEECCCCCCCCCC	47.96	22617229
549	Phosphorylation	PSGWGARSPPQYCGT CCCCCCCCCCCCCCC	40.16	22617229
594	Phosphorylation	EGLAAERSPLPPGAA HHHCCCCCCCCCCCC	23.46	22617229
610	Phosphorylation	DAKPKDLSDSSWIET CCCCCCCCCCCCCCC	45.65	22617229
613	Phosphorylation	PKDLSDSSWIETPSS CCCCCCCCCCCCHHH	36.74	-
617	Phosphorylation	SDSSWIETPSSIKSI CCCCCCCCHHHCCCC	21.24	25332170
620	Phosphorylation	SWIETPSSIKSIDSS CCCCCHHHCCCCCCC	34.93	25332170
623	Phosphorylation	ETPSSIKSIDSSDSG CCHHHCCCCCCCCCC	29.92	22617229
626	Phosphorylation	SSIKSIDSSDSGIYE HHCCCCCCCCCCHHH	34.08	22617229
629	Phosphorylation	KSIDSSDSGIYEQAK CCCCCCCCCHHHHHH	29.10	22617229
632	Phosphorylation	DSSDSGIYEQAKRRR CCCCCCHHHHHHHCC	12.91	-
641	Phosphorylation	QAKRRRISPADTPVS HHHHCCCCCCCCCCC	16.54	22617229
645	Phosphorylation	RRISPADTPVSESSS CCCCCCCCCCCCCCC	27.91	22617229
648	O-linked_Glycosylation	SPADTPVSESSSPLK CCCCCCCCCCCCCHH	32.72	30379171
648	Phosphorylation	SPADTPVSESSSPLK CCCCCCCCCCCCCHH	32.72	22617229
650	Phosphorylation	ADTPVSESSSPLKSE CCCCCCCCCCCHHHH	28.72	22617229
651	Phosphorylation	DTPVSESSSPLKSEV CCCCCCCCCCHHHHH	31.74	22617229
652	Phosphorylation	TPVSESSSPLKSEVL CCCCCCCCCHHHHHH	43.46	22617229
656	Phosphorylation	ESSSPLKSEVLAQRD CCCCCHHHHHHHHCH	40.39	-
666	Ubiquitination	LAQRDCEKNCAKDIS HHHCHHHHHHCHHHC	64.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBR1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSKP_HUMAN	CASK	physical	10749215
TSYL2_HUMAN	TSPYL2	physical	15066269
CSKP_HUMAN	CASK	physical	15066269
RMD5B_HUMAN	RMND5B	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.