IGSF5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IGSF5_HUMAN
• UniProt AC: Q9NSI5
• Protein Name: Immunoglobulin superfamily member 5
• Gene Name: IGSF5
• Organism: Homo sapiens (Human).
• Sequence Length: 407
• Subcellular Localization: Apical cell membrane ; Single-pass type I membrane protein . Cell junction, tight junction .
• Protein Description: Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia-spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells-Sertoli cells (By similarity)..
• Protein Sequence: MGQKERSTADTLPDLEEWKSAAGLRWWQTAVVDGSGSGNEVIEGPQNARVLKGSQARFNCTVSQGWKLIMWALSDMVVLSVRPMEPIITNDRFTSQRYDQGGNFTSEMIIHNVEPSDSGNIRCSLQNSRLHGSAYLTVQVMGELFIPSVNLVVAENEPCEVTCLPSHWTRLPDISWELGLLVSHSSYYFVPEPSDLQSAVSILALTPQSNGTLTCVATWKSLKARKSATVNLTVIRCPQDTGGGINIPGVLSSLPSLGFSLPTWGKVGLGLAGTMLLTPTCTLTIRCCCCRRRCCGCNCCCRCCFCCRRKRGFRIQFQKKSEKEKTNKETETESGNENSGYNSDEQKTTDTASLPPKSCESSDPEQRNSSCGPPHQRADQRPPRPASHPQASFNLASPEKVSNTTVV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	N-linked_Glycosylation	KGSQARFNCTVSQGW CCCCCCCCEEECHHH	18.26	UniProtKB CARBOHYD
103	N-linked_Glycosylation	QRYDQGGNFTSEMII CEECCCCCEEEEEEE	43.79	UniProtKB CARBOHYD
198	Phosphorylation	PEPSDLQSAVSILAL CCCHHHHHHHHHEEE	37.62	-
210	N-linked_Glycosylation	LALTPQSNGTLTCVA EEECCCCCCEEEEEE	42.07	UniProtKB CARBOHYD
231	N-linked_Glycosylation	ARKSATVNLTVIRCP CCCCCEEEEEEEECC	26.16	UniProtKB CARBOHYD
233	Phosphorylation	KSATVNLTVIRCPQD CCCEEEEEEEECCCC	14.53	-
241	Phosphorylation	VIRCPQDTGGGINIP EEECCCCCCCCCCCC	32.26	22210691
256	Phosphorylation	GVLSSLPSLGFSLPT HHHHCCCCCCCCCCC	46.55	22210691
387	Phosphorylation	QRPPRPASHPQASFN CCCCCCCCCCCCCCC	38.08	30266825
392	Phosphorylation	PASHPQASFNLASPE CCCCCCCCCCCCCCC	14.93	30266825
397	Phosphorylation	QASFNLASPEKVSNT CCCCCCCCCCCCCCC	36.44	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IGSF5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IGSF5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IGSF5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LNX1_HUMAN	LNX1	physical	16832352
LNX2_HUMAN	LNX2	physical	16832352

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.