TMC5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMC5_HUMAN
• UniProt AC: Q6UXY8
• Protein Name: Transmembrane channel-like protein 5
• Gene Name: TMC5
• Organism: Homo sapiens (Human).
• Sequence Length: 1006
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Probable ion channel..
• Protein Sequence: MSAYYRNNWSEEDPDYPDYSGSQNRTQGYLKTQGYPDVPGPLNNPDYPGTRSNPYSVASRTRPDYPGSLAEPNYPRSLSNPDYSGTRSNAYSAASRTSPDHPTSLPEPDYSEFQSHPYHRASSRQPDYPGSQRNPDFAGSSSSGNYAGSRTHPDHFGSLEPDYPGAQSNSDHPGPRANLNHPGSRKNLEHTSFRINPYADSLGKPDYPGADIQPNSPPFFGEPDYPSAEDNQNLPSTWREPDYSDAENGHDYGSSETPKMTRGVLSRTSSIQPSFRHRSDDPVGSLWGENDYPEGIEMASMEMANSYGHSLPGAPGSGYVNPAYVGESGPVHAYGNPPLSECDWHKSPQGQKLIASLIPMTSRDRIKAIRNQPRTMEEKRNLRKIVDKEKSKQTHRILQLNCCIQCLNSISRAYRRSKNSLSEILNSISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSFILNFSFIIIPQFTVAKKNTLQFTGLEFFTGVGYFRDTVMYYGFYTNSTIQHGNSGASYNMQLAYIFTIGACLTTCFFSLLFSMAKYFRNNFINPHIYSGGITKLIFCWDFTVTHEKAVKLKQKNLSTEIRENLSELRQENSKLTFNQLLTRFSAYMVAWVVSTGVAIACCAAVYYLAEYNLEFLKTHSNPGAVLLLPFVVSCINLAVPCIYSMFRLVERYEMPRHEVYVLLIRNIFLKISIIGILCYYWLNTVALSGEECWETLIGQDIYRLLLMDFVFSLVNSFLGEFLRRIIGMQLITSLGLQEFDIARNVLELIYAQTLVWIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPSKAWRASQMMTFFIFLLFFPSFTGVLCTLAITIWRLKPSADCGPFRGLPLFIHSIYSWIDTLSTRPGYLWVVWIYRNLIGSVHFFFILTLIVLIITYLYWQITEGRKIMIRLLHEQIINEGKDKMFLIEKLIKLQDMEKKANPSSLVLERREVEQQGFLHLGEHDGSLDLRSRRSVQEGNPRA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	WSEEDPDYPDYSGSQ CCCCCCCCCCCCCCC	11.91	-
19	Phosphorylation	EDPDYPDYSGSQNRT CCCCCCCCCCCCCCC	15.49	19060867
26	Phosphorylation	YSGSQNRTQGYLKTQ CCCCCCCCCCCHHCC	33.62	28152594
29	Phosphorylation	SQNRTQGYLKTQGYP CCCCCCCCHHCCCCC	8.66	28152594
31	Methylation	NRTQGYLKTQGYPDV CCCCCCHHCCCCCCC	30.25	115979899
32	Phosphorylation	RTQGYLKTQGYPDVP CCCCCHHCCCCCCCC	25.32	22210691
35	Phosphorylation	GYLKTQGYPDVPGPL CCHHCCCCCCCCCCC	6.09	28152594
47	Phosphorylation	GPLNNPDYPGTRSNP CCCCCCCCCCCCCCC	12.57	28152594
48 (in isoform 3)	Phosphorylation	-	45.09	-
50	Phosphorylation	NNPDYPGTRSNPYSV CCCCCCCCCCCCCCC	26.81	22210691
52	Phosphorylation	PDYPGTRSNPYSVAS CCCCCCCCCCCCCCC	41.83	22210691
55	Phosphorylation	PGTRSNPYSVASRTR CCCCCCCCCCCCCCC	21.74	28152594
56	Phosphorylation	GTRSNPYSVASRTRP CCCCCCCCCCCCCCC	16.68	28152594
59	Phosphorylation	SNPYSVASRTRPDYP CCCCCCCCCCCCCCC	31.84	22210691
61	Phosphorylation	PYSVASRTRPDYPGS CCCCCCCCCCCCCCC	44.02	28442448
65	Phosphorylation	ASRTRPDYPGSLAEP CCCCCCCCCCCCCCC	16.51	28442448
68	Phosphorylation	TRPDYPGSLAEPNYP CCCCCCCCCCCCCCC	21.65	28442448
74	Phosphorylation	GSLAEPNYPRSLSNP CCCCCCCCCCCCCCC	15.67	28152594
77	Phosphorylation	AEPNYPRSLSNPDYS CCCCCCCCCCCCCCC	31.48	26356563
79	Phosphorylation	PNYPRSLSNPDYSGT CCCCCCCCCCCCCCC	47.79	24670416
83	Phosphorylation	RSLSNPDYSGTRSNA CCCCCCCCCCCCCCC	15.40	28152594
84	Phosphorylation	SLSNPDYSGTRSNAY CCCCCCCCCCCCCCC	40.86	28152594
86	Phosphorylation	SNPDYSGTRSNAYSA CCCCCCCCCCCCCHH	25.61	28152594
88	Phosphorylation	PDYSGTRSNAYSAAS CCCCCCCCCCCHHHC	26.16	28152594
91	Phosphorylation	SGTRSNAYSAASRTS CCCCCCCCHHHCCCC	11.77	28152594
92	Phosphorylation	GTRSNAYSAASRTSP CCCCCCCHHHCCCCC	18.23	28152594
95	Phosphorylation	SNAYSAASRTSPDHP CCCCHHHCCCCCCCC	35.49	-
97	Phosphorylation	AYSAASRTSPDHPTS CCHHHCCCCCCCCCC	41.96	26356563
98	Phosphorylation	YSAASRTSPDHPTSL CHHHCCCCCCCCCCC	27.50	28348404
103	Phosphorylation	RTSPDHPTSLPEPDY CCCCCCCCCCCCCCH	39.20	23898821
104	Phosphorylation	TSPDHPTSLPEPDYS CCCCCCCCCCCCCHH	46.51	27966365
110	Phosphorylation	TSLPEPDYSEFQSHP CCCCCCCHHHHHCCC	22.33	27259358
111	Phosphorylation	SLPEPDYSEFQSHPY CCCCCCHHHHHCCCC	39.04	26356563
115	Phosphorylation	PDYSEFQSHPYHRAS CCHHHHHCCCCCCCC	31.58	28442448
118	Phosphorylation	SEFQSHPYHRASSRQ HHHHCCCCCCCCCCC	9.87	27259358
122	Phosphorylation	SHPYHRASSRQPDYP CCCCCCCCCCCCCCC	26.47	23312004
123	Phosphorylation	HPYHRASSRQPDYPG CCCCCCCCCCCCCCC	33.67	28152594
128	Phosphorylation	ASSRQPDYPGSQRNP CCCCCCCCCCCCCCC	19.04	28152594
131	Phosphorylation	RQPDYPGSQRNPDFA CCCCCCCCCCCCCCC	22.82	28152594
140	Phosphorylation	RNPDFAGSSSSGNYA CCCCCCCCCCCCCCC	24.50	23663014
141	Phosphorylation	NPDFAGSSSSGNYAG CCCCCCCCCCCCCCC	27.83	23663014
142	Phosphorylation	PDFAGSSSSGNYAGS CCCCCCCCCCCCCCC	43.92	23663014
143	Phosphorylation	DFAGSSSSGNYAGSR CCCCCCCCCCCCCCC	32.76	28442448
146	Phosphorylation	GSSSSGNYAGSRTHP CCCCCCCCCCCCCCC	18.83	23663014
149	Phosphorylation	SSGNYAGSRTHPDHF CCCCCCCCCCCCCCC	26.32	23663014
163	Phosphorylation	FGSLEPDYPGAQSNS CCCCCCCCCCCCCCC	17.80	21253578
168	Phosphorylation	PDYPGAQSNSDHPGP CCCCCCCCCCCCCCC	37.45	-
184	Phosphorylation	ANLNHPGSRKNLEHT CCCCCCCCHHCCCCC	44.53	23312004
191	Phosphorylation	SRKNLEHTSFRINPY CHHCCCCCCEECCCC	21.86	23312004
192	Phosphorylation	RKNLEHTSFRINPYA HHCCCCCCEECCCCH	17.90	27966365
243	Phosphorylation	STWREPDYSDAENGH CCCCCCCCCCCCCCC	21.11	23312004
244	Phosphorylation	TWREPDYSDAENGHD CCCCCCCCCCCCCCC	37.41	23312004
252	Phosphorylation	DAENGHDYGSSETPK CCCCCCCCCCCCCCC	17.15	23312004
254	Phosphorylation	ENGHDYGSSETPKMT CCCCCCCCCCCCCCC	20.83	23312004
255	Phosphorylation	NGHDYGSSETPKMTR CCCCCCCCCCCCCCC	40.92	23312004
257	Phosphorylation	HDYGSSETPKMTRGV CCCCCCCCCCCCCHH	30.11	23312004
266	Phosphorylation	KMTRGVLSRTSSIQP CCCCHHHHCCCCCCC	30.98	24719451
268	Phosphorylation	TRGVLSRTSSIQPSF CCHHHHCCCCCCCCC	24.37	22617229
269	Phosphorylation	RGVLSRTSSIQPSFR CHHHHCCCCCCCCCC	25.08	22617229
270	Phosphorylation	GVLSRTSSIQPSFRH HHHHCCCCCCCCCCC	25.32	27966365
361	Phosphorylation	IASLIPMTSRDRIKA HHHHCCCCCHHHHHH	18.43	-
362	Phosphorylation	ASLIPMTSRDRIKAI HHHCCCCCHHHHHHH	26.40	-
391	Phosphorylation	KIVDKEKSKQTHRIL HHCCHHHHHHHHHHH	30.96	24260401
463	Phosphorylation	LLKFNIFSFILNFSF HHHCCHHHHHHCCCE	13.95	-
583	Acetylation	VTHEKAVKLKQKNLS CCHHHHHHHHHCCHH	55.62	30592987
782	Phosphorylation	RNVLELIYAQTLVWI HHHHHHHHHHHHHHH	12.79	-
785	Phosphorylation	LELIYAQTLVWIGIF HHHHHHHHHHHHHHH	18.33	-
886	Phosphorylation	YSWIDTLSTRPGYLW HHHHHHHHCCCCEEE	25.18	24719451
956	Ubiquitination	FLIEKLIKLQDMEKK HHHHHHHHHHHHHHH	51.00	-
963	Ubiquitination	KLQDMEKKANPSSLV HHHHHHHHCCHHHEE	39.84	-
967	Phosphorylation	MEKKANPSSLVLERR HHHHCCHHHEEEEHH	35.79	26657352
968	Phosphorylation	EKKANPSSLVLERRE HHHCCHHHEEEEHHH	24.61	22985185
990	Phosphorylation	HLGEHDGSLDLRSRR ECCCCCCCCCHHHCC	25.43	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMC5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMC5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMC5_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TMC5_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.