1433Z_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 1433Z_RAT
• UniProt AC: P63102
• Protein Name: 14-3-3 protein zeta/delta
• Gene Name: Ywhaz
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 245
• Subcellular Localization: Cytoplasm. Melanosome. Located to stage I to stage IV melanosomes..
• Protein Description: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner..
• Protein Sequence: MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQPESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDKNELVQ -------CCHHHHHH	17.45	-
3	Acetylation	-----MDKNELVQKA -----CCHHHHHHHH	51.53	22902405
3	Ubiquitination	-----MDKNELVQKA -----CCHHHHHHHH	51.53	-
9	Acetylation	DKNELVQKAKLAEQA CHHHHHHHHHHHHHH	39.75	22902405
9	Ubiquitination	DKNELVQKAKLAEQA CHHHHHHHHHHHHHH	39.75	-
11	Acetylation	NELVQKAKLAEQAER HHHHHHHHHHHHHHH	56.09	72611863
11	Ubiquitination	NELVQKAKLAEQAER HHHHHHHHHHHHHHH	56.09	-
25	S-nitrosocysteine	RYDDMAACMKSVTEQ HHHHHHHHHHHHHHH	2.27	-
25	S-nitrosylation	RYDDMAACMKSVTEQ HHHHHHHHHHHHHHH	2.27	17629318
37	Phosphorylation	TEQGAELSNEERNLL HHHHHHCCHHHHHHH	33.43	28432305
45	Phosphorylation	NEERNLLSVAYKNVV HHHHHHHHHHHHHHH	14.10	27097102
48	Phosphorylation	RNLLSVAYKNVVGAR HHHHHHHHHHHHCCC	10.84	23984901
49	Ubiquitination	NLLSVAYKNVVGARR HHHHHHHHHHHCCCC	33.26	-
49	Acetylation	NLLSVAYKNVVGARR HHHHHHHHHHHCCCC	33.26	13583295
57	Phosphorylation	NVVGARRSSWRVVSS HHHCCCCCCHHHHHH	28.79	31136807
58	Phosphorylation	VVGARRSSWRVVSSI HHCCCCCCHHHHHHH	19.65	13583307
63	Phosphorylation	RSSWRVVSSIEQKTE CCCHHHHHHHHHHCC	23.81	28432305
64	Phosphorylation	SSWRVVSSIEQKTEG CCHHHHHHHHHHCCH	20.66	25403869
68	Acetylation	VVSSIEQKTEGAEKK HHHHHHHHCCHHHHH	35.44	22902405
68	Ubiquitination	VVSSIEQKTEGAEKK HHHHHHHHCCHHHHH	35.44	-
74	Acetylation	QKTEGAEKKQQMARE HHCCHHHHHHHHHHH	56.18	22902405
94	S-nitrosylation	ETELRDICNDVLSLL HHHHHHHHHHHHHHH	4.10	17629318
94	S-nitrosocysteine	ETELRDICNDVLSLL HHHHHHHHHHHHHHH	4.10	-
110	Phosphorylation	KFLIPNASQPESKVF HHCCCCCCCCCCEEE	53.56	22673903
114	Phosphorylation	PNASQPESKVFYLKM CCCCCCCCEEEEEEE	40.58	22673903
115	Acetylation	NASQPESKVFYLKMK CCCCCCCEEEEEEEC	34.40	22902405
120	Acetylation	ESKVFYLKMKGDYYR CCEEEEEEECCHHHH	27.47	13583319
120	Ubiquitination	ESKVFYLKMKGDYYR CCEEEEEEECCHHHH	27.47	-
122	Acetylation	KVFYLKMKGDYYRYL EEEEEEECCHHHHHH	47.22	14505049
122	Ubiquitination	KVFYLKMKGDYYRYL EEEEEEECCHHHHHH	47.22	-
128	Phosphorylation	MKGDYYRYLAEVAAG ECCHHHHHHHHHHCC	8.31	25403869
138	Ubiquitination	EVAAGDDKKGIVDQS HHHCCCCCCCCCCHH	58.60	-
138	Acetylation	EVAAGDDKKGIVDQS HHHCCCCCCCCCCHH	58.60	22902405
139	Ubiquitination	VAAGDDKKGIVDQSQ HHCCCCCCCCCCHHH	61.95	-
157	Ubiquitination	QEAFEISKKEMQPTH HHHHHHHHHHCCCCC	59.42	-
157	Acetylation	QEAFEISKKEMQPTH HHHHHHHHHHCCCCC	59.42	13583327
158	Ubiquitination	EAFEISKKEMQPTHP HHHHHHHHHCCCCCC	52.18	-
184	Phosphorylation	FYYEILNSPEKACSL HHHHHHCCHHHHHHH	30.87	30240740
190	Phosphorylation	NSPEKACSLAKTAFD CCHHHHHHHHHHHHH	35.90	29779826
205	Phosphorylation	EAIAELDTLSEESYK HHHHHHHCCCHHHCC	44.82	22108457
207	Phosphorylation	IAELDTLSEESYKDS HHHHHCCCHHHCCCH	41.22	27097102
210	Phosphorylation	LDTLSEESYKDSTLI HHCCCHHHCCCHHHH	33.17	8121835
211	Phosphorylation	DTLSEESYKDSTLIM HCCCHHHCCCHHHHH	23.30	23984901
214	Phosphorylation	SEESYKDSTLIMQLL CHHHCCCHHHHHHHH	22.44	23984901
215	Phosphorylation	EESYKDSTLIMQLLR HHHCCCHHHHHHHHH	30.36	23984901
226	Phosphorylation	QLLRDNLTLWTSDTQ HHHHHCCEEEECCCC	26.89	27097102
229	Phosphorylation	RDNLTLWTSDTQGDE HHCCEEEECCCCCCC	21.60	27097102
230	Phosphorylation	DNLTLWTSDTQGDEA HCCEEEECCCCCCCC	27.38	27097102
232	Phosphorylation	LTLWTSDTQGDEAEA CEEEECCCCCCCCCC	33.93	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
58	S	Phosphorylation	Kinase	PKA	-	Uniprot
232	T	Phosphorylation	Kinase	CK1	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
58	S	Phosphorylation	Phosphorylated on Ser-58 by PKA and protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.	-
58	S	Phosphorylation	Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53 (By similarity).	-
184	S	Phosphorylation	Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria.	-
232	T	Phosphorylation	Phosphorylation on Thr-232; inhibits binding of RAF1 (By similarity).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 1433Z_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLIC4_RAT	Clic4	physical	11563969

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.