CLIC4_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLIC4_RAT
• UniProt AC: Q9Z0W7
• Protein Name: Chloride intracellular channel protein 4
• Gene Name: Clic4
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 253
• Subcellular Localization: Endoplasmic reticulum. Membrane ; Single-pass membrane protein . Cytoplasm. Cytoplasmic vesicle membrane; Single-pass membrane protein. Nucleus. Cell membrane; Single-pass membrane protein. Exists both as soluble cytoplasmic protein and as membrane p
• Protein Description: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. May play a role in angiogenesis (By similarity)..
• Protein Sequence: MALSMPLNGLKEEDKEPLIELFVKAGSDGESIGNCPFSQRLFMILWLKGVVFSVTTVDLKRKPAHLQNLAPGTHPPFITFNSEVKTDVNKIEEFLEEVLCPPKYLKLSPKHPESNTAGMDIFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPGEIDENSMEDIKSSTRRFLDGDEMTLADCNLLPKLHIVKVVAKKYRNFDIPKGMTGIWRYLTNAYSRDEFTNTCPSDKEVEIAYSDVAKRLTK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MALSMPLNG ------CCCCCCCCC	14.35	-
4	Phosphorylation	----MALSMPLNGLK ----CCCCCCCCCCC	14.60	27097102
24	Acetylation	PLIELFVKAGSDGES HHHHHHHHCCCCCCC	39.43	-
106	Acetylation	LCPPKYLKLSPKHPE CCCHHHCCCCCCCCC	43.77	22902405
128	Phosphorylation	IFAKFSAYIKNSRPE HHHHHHHHHHCCCHH	15.95	25575281
130	Acetylation	AKFSAYIKNSRPEAN HHHHHHHHCCCHHHH	35.87	22902405
132	Phosphorylation	FSAYIKNSRPEANEA HHHHHHCCCHHHHHH	44.18	25575281
146	Acetylation	ALERGLLKTLQKLDE HHHHHHHHHHHHHHH	52.83	22902405
157	Phosphorylation	KLDEYLNSPLPGEID HHHHHHCCCCCCCCC	25.81	21373199
167	Phosphorylation	PGEIDENSMEDIKSS CCCCCCCCHHHHHHH	22.85	-
199	Acetylation	LPKLHIVKVVAKKYR CCCCCHHHHHHHHHC	30.32	22902405
199	Ubiquitination	LPKLHIVKVVAKKYR CCCCCHHHHHHHHHC	30.32	-
212	Acetylation	YRNFDIPKGMTGIWR HCCCCCCCCCHHHHH	62.74	22902405
233	Phosphorylation	SRDEFTNTCPSDKEV CCCCCCCCCCCCCCE	23.80	30181290
236	Phosphorylation	EFTNTCPSDKEVEIA CCCCCCCCCCCEEEE	64.56	30181290
244	Phosphorylation	DKEVEIAYSDVAKRL CCCEEEEHHHHHHHH	15.86	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLIC4_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLIC4_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLIC4_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
1433E_RAT	Ywhae	physical	11563969
1433Z_RAT	Ywhaz	physical	11563969
ACTB_RAT	Actb	physical	11563969
DYN1_RAT	Dnm1	physical	11563969
CAV1_HUMAN	CAV1	physical	11563969

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.